INT179550

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.24
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ywhaq) protein targeting (Ywhaq) nucleus (Ywhaq)
protein complex (Ywhaq) cytoplasm (Ywhaq)
Anatomy Link Frequency
plaques 2
neocortex 1
motor neuron 1
neural 1
Ywhaq (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 46 99.28 Very High Very High Very High
Inflammation 55 94.48 High High
Somatostatin 4 89.64 High High
imagery 121 87.48 High High
cerebral cortex 11 87.04 High High
positron emission tomography 122 86.88 High High
amygdala 6 85.44 High High
cINOD 20 81.52 Quite High
antagonist 4 70.44 Quite High
unmyelinated 7 54.24 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 18 99.12 Very High Very High Very High
Muscular Atrophy 1 99.06 Very High Very High Very High
Amyloid Plaque 77 99.00 Very High Very High Very High
Alzheimer's Dementia 48 98.72 Very High Very High Very High
Disease 476 98.24 Very High Very High Very High
Nerve Degeneration 2 97.94 Very High Very High Very High
Targeted Disruption 52 97.60 Very High Very High Very High
Insulin Resistance 7 97.36 Very High Very High Very High
INFLAMMATION 70 94.48 High High
Diabetes Mellitus 41 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alzheimer's disease is a progressive neurodegenerative disorder characterized by intra-cellular abnormally phosphorylated tau protein and extra-cellular beta amyloid plaques.
Phosphorylation (phosphorylated) of tau protein in plaques associated with neurodegenerative disease, disease and amyloid plaque
1) Confidence 0.03 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.98 Pain Relevance 0.16
For example, N-terminal Hsp90 inhibitors decreased motor neuron degeneration in a murine model of spinal and bulbar muscular atrophy (Waza et al., 2005) and reduced aggregated or hyperphosphorylated forms of tau protein in JNPL3 mice (Luo et al., 2007) and humanized tau protein transgenic mice (Dickey et al., 2007).
Phosphorylation (hyperphosphorylated) of tau protein in motor neuron associated with targeted disruption, muscular atrophy and nerve degeneration
2) Confidence 0.03 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 1.27 Pain Relevance 0.05
phosphorylation and hyperphosphorylation of tau protein in NIRKO mice as compared to controls.
Phosphorylation (hyperphosphorylation) of tau protein
3) Confidence 0.02 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2755760 Disease Relevance 0.61 Pain Relevance 0.39
phosphorylation and hyperphosphorylation of tau protein in NIRKO mice as compared to controls.
Phosphorylation (phosphorylation) of tau protein
4) Confidence 0.02 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2755760 Disease Relevance 0.62 Pain Relevance 0.39
fragment of a larger precursor protein (amyloid precursor protein [APP]), whereas intracellular NFT consist of hyperphosphorylated tau protein [1, 2].
Phosphorylation (hyperphosphorylated) of tau protein associated with alzheimer's dementia
5) Confidence 0.02 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2755760 Disease Relevance 1.16 Pain Relevance 0
Phosphorylated tau-protein binds to microtubules in order to facilitate their assembly, assuring the stability of the neural cytoskeleton.
Phosphorylation (Phosphorylated) of tau-protein in neural
6) Confidence 0.01 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.52 Pain Relevance 0.21
A report of AD-type pathology in an aged wolverine [153] described neuritic as well as diffuse plaques in the cortex and hippocampus, and intracellular NFTs containing phosphorylated tau protein in cortical and hippocampal neurons.
Phosphorylation (phosphorylated) of tau protein in plaques associated with hippocampus and disease
7) Confidence 0.01 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.46 Pain Relevance 0.16
The brain of the aged baboon contains phosphorylated tau protein [147,148], and an age-related accumulation of tau also occurs in the neocortex of the mouse lemur [149-151].
Phosphorylation (phosphorylated) of tau protein in neocortex
8) Confidence 0.01 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.63 Pain Relevance 0.12

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