INT179582

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 0.25
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cmtm7) molecular_function (Cmtm7) cellular_component (Cmtm7)
biological_process (Cmtm7)
Anatomy Link Frequency
clock neurons 3
dorsal 2
ventral 2
neurons 1
upper 1
Cmtm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 204 96.24 Very High Very High Very High
neuropeptide release 33 94.60 High High
Neurotransmitter 16 93.92 High High
Neuropeptide 14 92.36 High High
imagery 22 86.96 High High
medulla 4 84.40 Quite High
Action potential 33 80.40 Quite High
cocaine 158 70.72 Quite High
Hippocampus 1 47.44 Quite Low
cerebral cortex 1 30.00 Quite Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 76.96 Quite High
Lifespan 11 64.20 Quite High
Convulsion 1 50.96 Quite High
Anaerobic Bacterial Infections 12 47.28 Quite Low
Nervous System Malformation 2 44.88 Quite Low
Sleep Disorders 1 28.16 Quite Low
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 12 11.56 Low Low
Sprains And Strains 30 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 23 5.00 Very Low Very Low Very Low
Targeted Disruption 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, when Shaw is manipulated only in the PDF expressing LNv, rhythmic accumulation of PDF is not disrupted.
Gene_expression (expressing) of LNv
1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.09
Some flies show signs of possible internal desynchronization (e.g., upper panel in Figure 3B) but the effects are much milder than those resulting from LNv expression of other channel transgenes [17], [42].
Gene_expression (expression) of LNv in upper
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0.06 Pain Relevance 0
cry-GAL4/UAS-Shaw flies, which express in fewer clock neurons compared to tim-GAL4 (LNv, LNd, 4 DN1 and 2 DN3's) maintain rhythmic behavior (Figure 3C).
Gene_expression (flies) of LNv in clock neurons
3) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0.06 Pain Relevance 0
Indeed we find that altering Shaw levels in clock neurons disrupts the cyclic accumulation of PDF in the dorsal projections of the LNv neurons.
Gene_expression (neurons) of LNv in clock neurons
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.18
Surprisingly, when Shaw is manipulated only in the PDF expressing LNv, rhythmic accumulation of PDF is not disrupted.
Gene_expression (expressing) of LNv
5) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.09
In order to determine if changing the level of Shaw in clock neurons affects rhythmic accumulation of PDF in the dorsal projections of s-LNv neurons, we quantified PDF levels in LNv terminals in the dorsal brain during a LD cycle (Figure 6).
Gene_expression (levels) of LNv in dorsal
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0
Adding Pdf-GAL80 to tim-GAL4/UAS-Shaw to remove Shaw over-expression in the LNv has no effect on the hyperactive tim-GAL4/UAS-Shaw phenotype (Figure 2, compare E to D; Table 1).
Gene_expression (expression) of LNv
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.17
Under LD conditions, increasing Shaw levels in all clock neurons (LNv, LNd, DN1, DN2 and DN3), or in subsets of clock neurons (LNd and DNs or DNs alone) increases locomotor activity at night.
Gene_expression (levels) of LNv in clock neurons associated with eae
8) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.12
Pdf-GAL4 is expressed only in the small and large ventral lateral neurons (s- and l-LNv).
Gene_expression (expressed) of LNv in ventral
9) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.04
Clock neurons can be visualized and genetically accessed by using GAL4 drivers [37] that are controlled by clock-cell specific promoters such as those from the timeless (Figure 1A, C and E–G) and Pdf (Figure 1D) genes [26]–[27]. tim-GAL4 is expressed strongly in all clock neurons including the DN1, DN2, and DN3 groups and in the well characterized dorsal and ventral lateral neurons (LNd and LNv).
Gene_expression (groups) of LNv in ventral
10) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.04
Expression of PDF, the only known LNv output, is restricted to the LNvs and a few tritocerebral neurons.
Gene_expression (Expression) of LNv in neurons
11) Confidence 0.03 Published 2004 Journal PLoS Biology Section Body Doc Link PMC529317 Disease Relevance 0.13 Pain Relevance 0.12
Clock neurons can be visualized and genetically accessed by using GAL4 drivers [37] that are controlled by clock-cell specific promoters such as those from the timeless (Figure 1A, C and E–G) and Pdf (Figure 1D) genes [26]–[27]. tim-GAL4 is expressed strongly in all clock neurons including the DN1, DN2, and DN3 groups and in the well characterized dorsal and ventral lateral neurons (LNd and LNv).
Gene_expression (groups) of LNv in dorsal
12) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386553 Disease Relevance 0 Pain Relevance 0.04

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