INT179583

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.97
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transcription factor binding (Lmo4)
Anatomy Link Frequency
suprachiasmatic nucleus 1
sensory system 1
Lmo4 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 2 98.76 Very High Very High Very High
Central nervous system 5 97.96 Very High Very High Very High
Spinal cord 3 97.36 Very High Very High Very High
Inflammation 44 96.16 Very High Very High Very High
Neuropeptide 8 90.96 High High
cocaine 316 83.96 Quite High
medulla 10 75.52 Quite High
imagery 100 73.12 Quite High
trigeminal ganglion 66 62.80 Quite High
Inflammatory response 4 56.88 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 7 98.24 Very High Very High Very High
Diabetes Mellitus 4 96.76 Very High Very High Very High
INFLAMMATION 50 96.16 Very High Very High Very High
Leukemia 2 87.04 High High
Targeted Disruption 37 82.12 Quite High
Nervous System Malformation 4 75.52 Quite High
Cancer 80 69.04 Quite High
Breast Cancer 6 64.48 Quite High
Ganglion Cysts 70 62.80 Quite High
Wound Healing 3 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LIM-only proteins (LMO), which consist of LMO1, LMO2, LMO3, and LMO4, are involved in cell fate determination and differentiation during embryonic development [61].
Gene_expression (consist) of LMO4
1) Confidence 0.41 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.91 Pain Relevance 0.12
Interestingly, expression of a mouse homolog of Lmo, Lmo4, is highly enriched in the suprachiasmatic nucleus (SCN) (A.
Gene_expression (expression) of Lmo4 in suprachiasmatic nucleus
2) Confidence 0.33 Published 2004 Journal PLoS Biology Section Body Doc Link PMC529317 Disease Relevance 0.06 Pain Relevance 0.26
The LIM-domain transcription factor Islet1 is co-expressed with Brn3a in the sensory system [10], but in the CNS it is expressed primarily in motor neurons [28,29], and also has important roles in the development of the heart [30] and pancreatic islet cells [31].
Gene_expression (expressed) of LIM-domain transcription factor Islet1 in sensory system associated with central nervous system
3) Confidence 0.26 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.22 Pain Relevance 0.30
Furthermore, microarray analysis revealed that in many tissues, Lmo4 expression varies with circadian time (Panda et al. 2002).
Gene_expression (expression) of Lmo4
4) Confidence 0.25 Published 2004 Journal PLoS Biology Section Body Doc Link PMC529317 Disease Relevance 0.08 Pain Relevance 0.20
This promoter drives luciferase gene expression resulting in GAL4-induced luciferase expression [35].
Gene_expression (expression) of GAL4-induced
5) Confidence 0.01 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.71 Pain Relevance 0.16

General Comments

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