INT17963

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 6.53
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
carbohydrate metabolic process (Ldha) cytoplasm (Ldha)
Anatomy Link Frequency
cornea 2
lung 1
Ldha (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 30 99.16 Very High Very High Very High
Spinal cord 34 91.28 High High
Neuropeptide 10 88.80 High High
fibrosis 16 74.48 Quite High
cytokine 5 72.52 Quite High
Pain 6 57.80 Quite High
Analgesic 3 57.20 Quite High
Inflammation 54 45.00 Quite Low
isoflurane 3 38.28 Quite Low
anesthesia 8 37.48 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 31 99.96 Very High Very High Very High
Influenza Virus Infection 90 99.76 Very High Very High Very High
Injury 142 99.54 Very High Very High Very High
Keratitis 65 99.16 Very High Very High Very High
Weight Loss 30 98.78 Very High Very High Very High
Corneal Neovascularization 10 98.56 Very High Very High Very High
Infection 133 97.76 Very High Very High Very High
Toxicity 20 97.04 Very High Very High Very High
Nervous System Malformation 2 96.96 Very High Very High Very High
Aspergillus Infection 15 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One finding that was unexpected was the significant difference in expression level of the reference genes used on the array plate (Ldha, Rplp1, Hprt, and Rpl13a).
Gene_expression (expression) of Ldha
1) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.29 Pain Relevance 0.13
The significant difference in expression of the reference genes (Rplp1, Ldha, Hprt, and Rpl13a) is also intriguing.
Gene_expression (expression) of Ldha
2) Confidence 0.58 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.06 Pain Relevance 0.05
Expression of 8 HKGs (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], lactate dehydrogenase A [LDHA], ribosomal protein L5 [RPL5], ubiquitin C [UBC], peptidylprolyl isomerase A [PPIA], TATA-box binding protein [TBP1], and hypoxanthine guanine phosphoribosyl transferase [HPRT1]) in the cornea were measured at various time points by microarray hybridization or qRT–PCR and the data analyzed using geNorm and NormFinder.


Spec (analyzed) Gene_expression (Expression) of lactate dehydrogenase in cornea
3) Confidence 0.56 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2893048 Disease Relevance 0.84 Pain Relevance 0
In this paper, we establish models of experimental corneal neovascularization (CorNV), fungal keratitis (FK) and corneal wound in mice and study the expression patterns of three traditional HKGs (ACTB, lactate dehydrogenase [LDHA], and GAPDH), five new HKGs (ubiquitin C [UBC] [14], peptidylprolyl isomerase A [PPIA] [15], TATA-box binding protein [TBP] [16], hypoxanthine guanine phosphoribosyl transferase [HPRT1] [17], and ribosomal protein L5 [RPL5] [18]).
Gene_expression (expression) of lactate dehydrogenase associated with corneal neovascularization, injury and keratitis
4) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2893048 Disease Relevance 0.40 Pain Relevance 0.04
Expression of 8 HKGs (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], lactate dehydrogenase A [LDHA], ribosomal protein L5 [RPL5], ubiquitin C [UBC], peptidylprolyl isomerase A [PPIA], TATA-box binding protein [TBP1], and hypoxanthine guanine phosphoribosyl transferase [HPRT1]) in the cornea were measured at various time points by microarray hybridization or qRT–PCR and the data analyzed using geNorm and NormFinder.


Spec (analyzed) Gene_expression (Expression) of LDHA in cornea
5) Confidence 0.56 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2893048 Disease Relevance 0.84 Pain Relevance 0
Statistical ANOVA showed that PPIA and RPL5 were among the genes with most stable expression levels (i.e., lowest CV) while LDHA and GAPDH were the genes with the most variable expression in the CorNV model (Figure 2).
Gene_expression (expression) of LDHA
6) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2893048 Disease Relevance 0.64 Pain Relevance 0
In this paper, we establish models of experimental corneal neovascularization (CorNV), fungal keratitis (FK) and corneal wound in mice and study the expression patterns of three traditional HKGs (ACTB, lactate dehydrogenase [LDHA], and GAPDH), five new HKGs (ubiquitin C [UBC] [14], peptidylprolyl isomerase A [PPIA] [15], TATA-box binding protein [TBP] [16], hypoxanthine guanine phosphoribosyl transferase [HPRT1] [17], and ribosomal protein L5 [RPL5] [18]).
Gene_expression (expression) of LDHA associated with corneal neovascularization, injury and keratitis
7) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2893048 Disease Relevance 0.40 Pain Relevance 0.04
Acetaminophen caused DNA damage from 1-4 hr onward and produced significant release of lactate dehydrogenase and [3H]adenine nucleotides at later times.
Gene_expression (produced) of lactate dehydrogenase associated with paracetamol
8) Confidence 0.31 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1957310 Disease Relevance 0.44 Pain Relevance 0.51
In response to hypoxia, expression of glycolytic enzymes such as lactate dehydrogenase (LDH)5, are induced to promote glycolysis as a source of ATP [17-20].
Gene_expression (expression) of lactate dehydrogenase associated with hypoxia
9) Confidence 0.17 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.05 Pain Relevance 0.10
Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) levels were measured.
Gene_expression (levels) of lactate dehydrogenase
10) Confidence 0.16 Published 2008 Journal Hum Exp Toxicol Section Abstract Doc Link 18715889 Disease Relevance 0.38 Pain Relevance 1.63
Serum albumin and lactate dehydrogenase content of BALF
Gene_expression (content) of lactate dehydrogenase
11) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.31 Pain Relevance 0
80°C for future use in determining levels of serum albumin, lactate dehydrogenase, and influenza-specific antibody.


Gene_expression (levels) of lactate dehydrogenase associated with influenza virus infection
12) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.38 Pain Relevance 0
In mice treated 9x with the PCN, the protection against a subsequent primary influenza virus infection was characterized by a significantly greater reduction in viral burdens by day 7 post-infection (Figure 3A), and by the absence of any weight loss (Figure 3B), and lung damage, as indicated by the decreased levels of albumin (Figure 3C) and lactate dehydrogenase (LDH) (Figure 3D) recovered from the broncho-alveolar lavage fluid (BALF) [11], [12].
Gene_expression (levels) of lactate dehydrogenase in lung associated with weight loss, influenza virus infection and infection
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.52 Pain Relevance 0
Measurement of lactate dehydrogenase leakage
Gene_expression (leakage) of lactate dehydrogenase
14) Confidence 0.05 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0 Pain Relevance 0

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