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Context Info
Confidence 0.36
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
cerebellar granule cells 2
liver 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.04 Very High Very High Very High
Kinase C 1 96.40 Very High Very High Very High
Dopamine 1 93.44 High High
nMDA receptor antagonist 1 65.44 Quite High
Action potential 20 63.84 Quite High
Catecholamine 10 62.64 Quite High
Neurotransmitter 2 55.96 Quite High
Glutamate receptor 6 53.44 Quite High
long-term potentiation 28 42.92 Quite Low
nMDA receptor 10 28.52 Quite Low
Disease Link Frequency Relevance Heat
Death 6 100.00 Very High Very High Very High
Necrosis 3 75.60 Quite High
Pheochromocytoma 16 63.28 Quite High
Apoptosis 1 46.16 Quite Low
Targeted Disruption 5 10.28 Low Low
Body Weight 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CNQX and AP5 administration reduced the amplitude of the [Ca2+]i transients at the stimulus position (region b of Figure 3B) to 35.1±9.6% and 42.7±12.8% of the control condition in the cases of the 80 and 200 µA stimuli, respectively (n?
Negative_regulation (reduced) of Regulation (amplitude) of Ca2
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966408 Disease Relevance 0 Pain Relevance 0.03
Hepatotoxic doses of acetaminophen cause widespread alkylation of liver and early loss of cytosolic Ca2+ regulation.
Negative_regulation (loss) of Regulation (regulation) of Ca2 in liver associated with paracetamol
2) Confidence 0.26 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1957310 Disease Relevance 0.36 Pain Relevance 0.31
Previous studies reported cell death of cerebellar granule cells, alterations of Ca2+ homeostasis in human neutrophils and brain microsomes, and arachidonic acid release and protein kinase C translocation in cerebellar granule cells; inhibition of dopamine reuptake in rat brain synaptic vesicles has been reported after in vitro exposure to DE-71 in the micromolar range (2–20 ?
Negative_regulation (reported) of Regulation (alterations) of Ca2 in cerebellar granule cells associated with dopamine, kinase c and death
3) Confidence 0.05 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.22 Pain Relevance 0.24

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