INT179644

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 13.74
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RENBP)
Anatomy Link Frequency
chondrocytes 1
blood 1
Urine 1
RENBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 52 99.86 Very High Very High Very High
Kinase C 20 99.66 Very High Very High Very High
alcohol 30 96.44 Very High Very High Very High
beta blocker 5 88.60 High High
Multiple sclerosis 3 81.68 Quite High
Inflammation 88 80.28 Quite High
rheumatoid arthritis 23 79.20 Quite High
Pain 25 73.20 Quite High
methotrexate 1 70.88 Quite High
Migraine 2 69.84 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 348 99.92 Very High Very High Very High
Pressure And Volume Under Development 34 99.60 Very High Very High Very High
Calcification 170 99.30 Very High Very High Very High
Aging 65 99.24 Very High Very High Very High
Volume Depletion And Dehydration 80 99.04 Very High Very High Very High
Hyperglycemia 78 97.76 Very High Very High Very High
Disorders Of Creatine Metabolism 24 97.32 Very High Very High Very High
Stress 85 96.06 Very High Very High Very High
Disease 123 93.60 High High
Disorder Of Lipid Metabolism 179 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rudimentary forms of acupuncture which probably arose during the Stone Age have survived in many parts of the world right down to present day.
Gene_expression (probably) of Age associated with acupuncture
1) Confidence 0.35 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2206232 Disease Relevance 0.22 Pain Relevance 0.32
Rudimentary forms of acupuncture which probably arose during the Stone Age have survived in many parts of the world right down to present day.
Gene_expression (probably) of Age associated with acupuncture
2) Confidence 0.35 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2206232 Disease Relevance 0 Pain Relevance 0.17
Above all, age and HD age are important risk factors, together with serum phosphate, serum calcium and CaxP product.
Gene_expression (product) of age
3) Confidence 0.31 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.57 Pain Relevance 0
Calcium (p = 0,036) is a risk factor in moderate delta increment of Agatston score, but for severe calcification other variables are statistically significant: age (p = 0,036), PTH (p = 0,030) and, as protective factor, Fetuin-A (p = 0,023).
Gene_expression (significant) of age associated with calcification
4) Confidence 0.31 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.40 Pain Relevance 0
Above all, age and HD age are important risk factors, together with serum phosphate, serum calcium and CaxP product.
Gene_expression (product) of age
5) Confidence 0.31 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.57 Pain Relevance 0
Age and HD vintage, PTH and CRP are significant factors of coronary calcifications on the bivariate analysis while regression analysis selected Age and HD age.
Gene_expression (selected) of age
6) Confidence 0.28 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.43 Pain Relevance 0.04
Age and HD vintage, PTH and CRP are significant factors of coronary calcifications on the bivariate analysis while regression analysis selected Age and HD age.
Gene_expression (selected) of Age
7) Confidence 0.28 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.43 Pain Relevance 0.04
NAG and RBP models were adjusted for age, sex, BMI, systolic blood pressure, current/former worker status, alcohol ingestion, and diabetes. 41 ?
Gene_expression (models) of RBP in blood associated with diabetes mellitus and alcohol
8) Confidence 0.13 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.82 Pain Relevance 0.05
Urine creatinine was measured in spot samples (for adjustment of NAG and RBP) and in the 4-hr sample after DMSA (for determination of measured creatinine clearance and adjustment of DMSA-chelatable lead levels), using a modification of the Sigma kit (Sigma Chemical Company, St.
Gene_expression (adjustment) of RBP in Urine associated with disorders of creatine metabolism
9) Confidence 0.13 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253707 Disease Relevance 0.24 Pain Relevance 0
Fractional polynomials can be fitted for narrow intervals, but as the polynomial functions may tend towards plus or minus infinity, it is difficult to fit one fractional polynomial over the wide age ranges needed without experiencing what is called Runge's phenomenon, where the included data points are fitted very well, but with dramatic error between them. [24]
Gene_expression (ranges) of age
10) Confidence 0.12 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 0.05 Pain Relevance 0
The baseline probability of having diabetes at this age (PopDM) using the coefficients in the Additional file 1 is:
Gene_expression (using) of age associated with diabetes mellitus
11) Confidence 0.12 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 0.40 Pain Relevance 0.08
PopHDL = 1.4 (constant with age)
Gene_expression (constant) of age
12) Confidence 0.12 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.41 Pain Relevance 0
The baseline probability of having diabetes at this age (PopDM) using the coefficients in the Additional file 1 is:
Gene_expression (this) of age associated with diabetes mellitus
13) Confidence 0.12 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 0.40 Pain Relevance 0.08
Nerlich et al 27 found that collagen type X was expressed by nuclear chondrocytes at a higher age and was associated with advanced degenerative disc alterations.
Gene_expression (expressed) of age in chondrocytes
14) Confidence 0.11 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.41 Pain Relevance 0
Simple covariate models including only sex and age were also used for analyses.
Gene_expression (sex) of age
15) Confidence 0.09 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.64 Pain Relevance 0
On the other hand, longitudinal analysis may still identify the relationship, by examining the association of the combination of SNP allele and age with phenotype in aging individuals, through a SNP × age interaction term.
Gene_expression (allele) of age associated with aging
16) Confidence 0.09 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.38 Pain Relevance 0
Thus, at least for most of the RBCs, age was not a significant determinant of the observed differences in hydration rate and hence of Pcat activation.
Gene_expression (most) of age
17) Confidence 0.07 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0.28 Pain Relevance 0
Preparation of RBCs for the age-PMCA correlation study
Gene_expression (Preparation) of age
18) Confidence 0.07 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
Thus, at least for most of the RBCs, age was not a significant determinant of the observed differences in hydration rate and hence of Pcat activation.
Gene_expression (activation) of age
19) Confidence 0.07 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0.28 Pain Relevance 0
The samples were blinded with only sex and age noted, and stored at ?
Gene_expression (noted) of age
20) Confidence 0.07 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 1.54 Pain Relevance 0.10

General Comments

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