INT179656

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.44
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
neutrophils 4
brain 1
epithelial cell 1
endothelium 1
promyelocytes 1
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 188 100.00 Very High Very High Very High
Arthritis 263 98.44 Very High Very High Very High
chemokine 45 95.96 Very High Very High Very High
Inflammation 525 94.80 High High
noradrenaline 2 94.48 High High
methotrexate 3 93.80 High High
rheumatoid arthritis 93 93.64 High High
Dopamine 8 93.08 High High
Catecholamine 2 92.88 High High
amygdala 62 86.88 High High
Disease Link Frequency Relevance Heat
Cancer 153 100.00 Very High Very High Very High
Disease 189 98.92 Very High Very High Very High
Emphysema 104 98.52 Very High Very High Very High
Arthritis 275 98.44 Very High Very High Very High
Anxiety Disorder 54 97.64 Very High Very High Very High
Lymphatic System Cancer 52 96.72 Very High Very High Very High
Necrosis 24 96.40 Very High Very High Very High
Infection 15 96.08 Very High Very High Very High
Toxicity 1 95.20 Very High Very High Very High
INFLAMMATION 520 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antileukoproteinase, an inhibitor of neutrophil protease, completely abolished the disease [73] by inhibiting leukocyte attachment to the synovial endothelium [74], but the disease modifying anti-rheumatic drug methotrexate did not [75].
Gene_expression (protease) of neutrophil in endothelium associated with disease and methotrexate
1) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.50 Pain Relevance 0.85
Mice depleted of neutrophils using anti-Gr-1 (RB6) antibodies are resistant [126] and neutrophil expression of leukotriene B4 receptor BLT1 was reported to be absolutely required for arthritis generation and chemokine production in this model [127].
Gene_expression (expression) of neutrophil in neutrophils associated with chemokine and arthritis
2) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.58 Pain Relevance 0.30
Deficiency in it decreased arthritis development significantly, possibly via matrix metalloproteinase (MMP)13 and neutrophil infiltration through MIP-2 [77].
Gene_expression (infiltration) of neutrophil in neutrophil associated with metalloproteinase and arthritis
3) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.44 Pain Relevance 0.87
Strikingly, we found that the viral effective population size (Ne) in the tumor clade for both patients expanded ?
Gene_expression (expanded) of Ne associated with cancer
4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 1.40 Pain Relevance 0.03
NE binds very stably to elastin in an active form, and ?
Gene_expression (very) of NE
5) Confidence 0.12 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.30 Pain Relevance 0.08
NE is present at millimolar concentrations in each azurophil granule of PMN, which is more than 100-fold higher than the concentration of ?
Gene_expression (present) of NE
6) Confidence 0.12 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.91 Pain Relevance 0.09
Neutrophil elastase is a serine protease that is synthesized in the neutrophils and secreted following neutrophils activation.
Gene_expression (synthesized) of Neutrophil elastase in neutrophils
7) Confidence 0.12 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.08 Pain Relevance 0.21
NE, CG, PR3, MMPs-8 and -9 (which lack transmembrane domains or glycosylphosphatidyl-inositol anchors) are also expressed on the surface of activated PMN (Owen et al 1995a, 1995b, 2003, 2004; Owen and Campbell 1998; Campbell et al 2000) (Figure 4).
Gene_expression (expressed) of NE associated with metalloproteinase
8) Confidence 0.11 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.08 Pain Relevance 0.09
NE, MMP-9, and ADAMs-10 and -17 increase epithelial cell expression of MUC5AC, a major mucin protein, by activating epithelial growth factor receptor (EGFR) through shedding of membrane – bound pro-transforming growth factor (TGF)-?.
Gene_expression (expression) of NE in epithelial cell
9) Confidence 0.11 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.50 Pain Relevance 0.32
The highly related serine protease known also as neutrophil elastase, proteinase 3 and cathepsin G are exclusively detected in promyelocytes and packaged in azurophil granules [57,58], whereas carbonic anhydrase 1 is expressed in adult human and mouse erythroid cells and colon epithelia, from two distinct promoters [59].
Gene_expression (detected) of neutrophil elastase in promyelocytes
10) Confidence 0.10 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.07 Pain Relevance 0.03
Proteinases such as human neutrophil elastase, porcine pancreatic elastase, or papain produce an efficient enzymatic induction of panacinar emphysema after a single intrapulmonary challenge [150,151].
Gene_expression (produce) of neutrophil elastase in neutrophil associated with emphysema
11) Confidence 0.06 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 0.89 Pain Relevance 0.07
This was an unexpected finding because NE is not produced in these mice.
Neg (not) Gene_expression (produced) of NE
12) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.57 Pain Relevance 0.30
Mechanisms of NE production and routes of its delivery in the brain
Gene_expression (production) of NE in brain
13) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.15 Pain Relevance 0.29

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