INT179661

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.59
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
eye 2
extracellular matrix 2
macrophage 1
Eln (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 90.24 High High
Inflammation 172 86.24 High High
Inflammatory mediators 17 78.16 Quite High
cytokine 26 73.44 Quite High
metalloproteinase 52 72.04 Quite High
Thoracotomy 6 28.48 Quite Low
Angina 3 16.32 Low Low
fibrosis 20 15.28 Low Low
corticosteroid 18 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Exfoliation Syndrome 183 99.28 Very High Very High Very High
Injury 95 99.14 Very High Very High Very High
Fibrosis 35 94.88 High High
Emphysema 116 94.60 High High
Targeted Disruption 12 94.00 High High
Syndrome 6 93.48 High High
Pulmonary Disease 380 92.00 High High
INFLAMMATION 181 90.24 High High
Adhesions 11 87.12 High High
Cancer 126 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All excised healed wounds were paraffin-embedded, and sections were stained with Hematoxylin & Eosin, Masson Trichrome, and Elastin Van Gieson.
Gene_expression (stained) of Elastin Van associated with injury
1) Confidence 0.56 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501115 Disease Relevance 0.99 Pain Relevance 0
At 3 days the top networks identified by IPA involve cell cycle progression (up-regulation of Foxm1, Cdc2, Cdc20, Ccnd1 and IL6 - Figure 4A), and activation of fibroblastic cells with production of extracellular matrix components (up-regulation of Igf1, Tnfrsf12A, Eln, Fbn1, Col3A1, Serpine1 and Thbs1 - Figure 4B).
Gene_expression (production) of Eln in extracellular matrix
2) Confidence 0.35 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.47 Pain Relevance 0.24
Moreover, LOXL1 and elastin were found to be expressed in various ocular tissues, and LOXL1 mRNA expression was differentially regulated dependent on the phase of progression of the fibrotic process and stages of XFS syndrome [30,31].
Gene_expression (expressed) of elastin associated with fibrosis, exfoliation syndrome and syndrome
3) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.92 Pain Relevance 0
XFS is proposed to arise from abnormal production and aggregation of elastin microfibrillar components produced by various cell types of the eye and other extraocular tissues [1,3,30].
Gene_expression (produced) of elastin in eye associated with exfoliation syndrome
4) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.87 Pain Relevance 0
XFS is proposed to arise from abnormal production and aggregation of elastin microfibrillar components produced by various cell types of the eye and other extraocular tissues [1,3,30].
Gene_expression (production) of elastin in eye associated with exfoliation syndrome
5) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.86 Pain Relevance 0
NE binds very stably to elastin in an active form, and ?
Gene_expression (very) of elastin
6) Confidence 0.13 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.30 Pain Relevance 0.08
These animals also fail to develop macrophage accumulation in response to cigarette smoke, an effect that could be related to MMP-12 induced generation of elastin fragments that are chemotactic for monocytes [175,176].
Gene_expression (generation) of elastin in macrophage
7) Confidence 0.08 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 1.09 Pain Relevance 0.17
Later, glycosaminoglycan and elastin levels normalize again but collagen levels are enhanced.
Gene_expression (levels) of elastin
8) Confidence 0.08 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 1.05 Pain Relevance 0.07
LOX, a copper-dependent amine oxidase, was initially reported as responsible for the catalysis of collagen and elastin cross-linking within the extracellular matrix [40].
Gene_expression (cross) of elastin in extracellular matrix
9) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.04 Pain Relevance 0.03

General Comments

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