INT179665

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.19
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
neutrophil 2
lung 1
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 81 98.76 Very High Very High Very High
Inflammation 308 94.80 High High
Arthritis 4 75.16 Quite High
fibrosis 13 59.44 Quite High
cytokine 61 37.20 Quite Low
chemokine 42 5.00 Very Low Very Low Very Low
antagonist 38 5.00 Very Low Very Low Very Low
Bioavailability 22 5.00 Very Low Very Low Very Low
corticosteroid 19 5.00 Very Low Very Low Very Low
Inflammatory mediators 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Emphysema 105 100.00 Very High Very High Very High
Apoptosis 33 99.32 Very High Very High Very High
Nicotine Addiction 133 95.20 Very High Very High Very High
Pneumonia 29 95.20 Very High Very High Very High
Pulmonary Disease 522 94.40 High High
Targeted Disruption 9 94.00 High High
Toxicity 2 89.00 High High
INFLAMMATION 318 87.76 High High
Cancer 13 75.60 Quite High
Arthritis 4 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the major actions of neutrophil elastase is its ability to degrade matrix proteins and appears to be a key enzyme in the development of hereditary due to ?
Protein_catabolism (degrade) of neutrophil elastase in neutrophil
1) Confidence 0.15 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.99 Pain Relevance 0.24
Therefore, neutrophil elastase may play a role in emphysema and lung remodeling through matrix degradation and by inducing apoptosis.
Protein_catabolism (degradation) of neutrophil elastase in lung associated with emphysema and apoptosis
2) Confidence 0.14 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.07 Pain Relevance 0.16
Quantum bursts of NE-mediated proteolytic activity associated with PMN migrating on ECM proteins are 10-fold larger in area and 4-fold longer in duration when PMN are bathed in serum from PiZZ patients compared to serum from healthy PiMM subjects (Campbell et al 1999), due to defective confinement of PMN-derived NE-mediated ECM degradation.
Protein_catabolism (degradation) of NE
3) Confidence 0.12 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.38 Pain Relevance 0.08
Each of these elastases inactivated the endogenous inhibitor of the other, with macrophage elastase degrading alpha1-antitrypsin and neutrophil elastase degrading tissue inhibitor of metalloproteinase-1 [48].
Protein_catabolism (degrading) of neutrophil elastase in neutrophil associated with metalloproteinase
4) Confidence 0.08 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 0.75 Pain Relevance 0.05

General Comments

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