INT179666

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
neutrophil 4
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 87 99.80 Very High Very High Very High
chemokine 7 98.80 Very High Very High Very High
Inflammation 154 86.60 High High
fibrosis 11 86.60 High High
metalloproteinase 47 65.84 Quite High
cytokine 28 48.44 Quite Low
rheumatoid arthritis 31 5.00 Very Low Very Low Very Low
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Emphysema 61 99.84 Very High Very High Very High
Arthritis 91 99.80 Very High Very High Very High
INFLAMMATION 157 86.60 High High
Fibrosis 13 86.60 High High
Adhesions 4 85.96 High High
Hyperplasia 3 80.72 Quite High
Pulmonary Disease 234 77.72 Quite High
Lung Cancer 2 74.56 Quite High
Pulmonary Emphysema 6 68.40 Quite High
Hypersensitivity 4 52.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice depleted of neutrophils using anti-Gr-1 (RB6) antibodies are resistant [126] and neutrophil expression of leukotriene B4 receptor BLT1 was reported to be absolutely required for arthritis generation and chemokine production in this model [127].
Positive_regulation (required) of in neutrophil Gene_expression (expression) of neutrophil in neutrophils associated with chemokine and arthritis
1) Confidence 0.21 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.63 Pain Relevance 0.35
NE binds very stably to elastin in an active form, and ?
Positive_regulation (very) of Gene_expression (very) of NE
2) Confidence 0.09 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.30 Pain Relevance 0.08
Proteinases such as human neutrophil elastase, porcine pancreatic elastase, or papain produce an efficient enzymatic induction of panacinar emphysema after a single intrapulmonary challenge [150,151].
Positive_regulation (induction) of Gene_expression (produce) of neutrophil elastase in neutrophil associated with emphysema
3) Confidence 0.04 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 0.90 Pain Relevance 0.07

General Comments

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