INT179668

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.08
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp12) extracellular region (Mmp12) proteinaceous extracellular matrix (Mmp12)
Anatomy Link Frequency
macrophage 8
lung 4
Mmp12 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 159 88.96 High High
Inflammation 313 88.24 High High
fibrosis 38 85.68 High High
antagonist 15 81.36 Quite High
chemokine 10 55.76 Quite High
Inflammatory mediators 42 34.04 Quite Low
cytokine 29 5.00 Very Low Very Low Very Low
substance P 11 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
corticosteroid 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 524 99.60 Very High Very High Very High
Emphysema 92 98.62 Very High Very High Very High
Disease 32 97.96 Very High Very High Very High
Pulmonary Emphysema 29 95.04 Very High Very High Very High
Burns 4 91.04 High High
INFLAMMATION 283 88.24 High High
Fibrosis 46 85.68 High High
Nicotine Addiction 56 79.68 Quite High
Lung Injury 28 76.52 Quite High
Pneumonia 85 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Signaling through PAR-1 increases macrophage MMP-12 synthesis (Raza et al 2000; Churg et al 2007b).
Positive_regulation (increases) of Gene_expression (synthesis) of MMP-12 in macrophage
1) Confidence 0.47 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.59 Pain Relevance 0
Early studies failed to detect increased expression of MMP-12 in lung samples (Finlay et al 1997; Imai et al 2001), but more recent studies using other techniques have demonstrated increased levels of MMP-12 in human COPD (Grumelli et al 2004; Molet et al 2005; Woodruff et al 2005; Demedts et al 2006).
Positive_regulation (increased) of Gene_expression (expression) of MMP-12 in lung associated with pulmonary disease
2) Confidence 0.41 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.14 Pain Relevance 0.19
Chronic CS-exposure revealed significantly increased MMP-12 staining in macrophages of WT mice, compared to air-exposed controls (Figure 5).
Positive_regulation (increased) of Gene_expression (staining) of MMP-12 in macrophages
3) Confidence 0.31 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.37 Pain Relevance 0.13
1-PI inhibiting both PMN serine proteinase-mediated ECM destruction and thrombin- or plasmin-induced increases in macrophage MMP-12 production (Churg et al 2003b, 2007b).


Positive_regulation (increases) of Gene_expression (production) of MMP-12 in macrophage
4) Confidence 0.29 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.44 Pain Relevance 0.15
Early studies failed to detect increased expression of MMP-12 in lung samples (Finlay et al 1997; Imai et al 2001), but more recent studies using other techniques have demonstrated increased levels of MMP-12 in human COPD (Grumelli et al 2004; Molet et al 2005; Woodruff et al 2005; Demedts et al 2006).
Positive_regulation (increased) of Gene_expression (levels) of MMP-12 in lung associated with pulmonary disease
5) Confidence 0.29 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.96 Pain Relevance 0.11
6-null mice develop age-related emphysema through the loss of activation of latent TGF-beta which leads to an increase in macrophage MMP-12 expression [171].
Positive_regulation (increase) of Gene_expression (expression) of MMP-12 in macrophage associated with emphysema
6) Confidence 0.23 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 0.57 Pain Relevance 0

General Comments

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