INT179686

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 14.10
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 4
COPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 273 100.00 Very High Very High Very High
metalloproteinase 153 100.00 Very High Very High Very High
fibrosis 91 100.00 Very High Very High Very High
depression 48 100.00 Very High Very High Very High
corticosteroid 24 94.84 High High
Inflammatory response 22 86.20 High High
Nortriptyline 1 73.12 Quite High
Pain 1 69.56 Quite High
tolerance 3 65.36 Quite High
Inflammatory mediators 31 44.88 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 788 100.00 Very High Very High Very High
Nicotine Addiction 434 100.00 Very High Very High Very High
INFLAMMATION 289 100.00 Very High Very High Very High
Influenza Virus Infection 181 100.00 Very High Very High Very High
Disease 108 100.00 Very High Very High Very High
Adhesions 100 100.00 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 69 100.00 Very High Very High Very High
Depression 57 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 22 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 19 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indirect studies of influenza in COPD exacerbations
Regulation (influenza) of Gene_expression (exacerbations) of COPD associated with pulmonary disease and influenza virus infection
1) Confidence 0.34 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692119 Disease Relevance 2.14 Pain Relevance 0
Effect on COPD symptoms
Regulation (Effect) of Gene_expression (symptoms) of COPD associated with pulmonary disease
2) Confidence 0.21 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706613 Disease Relevance 0.55 Pain Relevance 0
However, the influence of smoking and its cessation on airway inflammation and MMP-12 expression during COPD is still unknown.
Regulation (influence) of Gene_expression (expression) of COPD associated with pulmonary disease, nicotine addiction, inflammation and metalloproteinase
3) Confidence 0.20 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2200652 Disease Relevance 1.81 Pain Relevance 0.36
immunoreactivity in the IPF and COPD lung
Regulation (immunoreactivity) of Gene_expression (lung) of COPD in lung associated with fibrosis and pulmonary disease
4) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.03 Pain Relevance 0.24
Animal models should not only assess histopathological features but also attempt to focus on functional features of human COPD such as airflow limitation, mucus hypersecretion, chronic cough and exacerbations, and also on pharmacological features such as corticosteroid resistance or diminished ?
Regulation (focus) of Gene_expression (features) of COPD associated with corticosteroid, pulmonary disease and cough
5) Confidence 0.17 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 0.86 Pain Relevance 0.05
A possible causal effect of depression on COPD exacerbations and hospitalizations has been suggested.[18] Chronic bronchitis is strongly associated with depression and anxiety.[19] As depression and/or anxiety may not only interfere with an attempt to stop smoking, but also contribute significantly to experiencing low quality of life, it is important to consider these disorders.[20]
Spec (possible) Regulation (effect) of Gene_expression (exacerbations) of COPD associated with nicotine addiction, pulmonary disease, depression, anxiety disorder and bronchitis
6) Confidence 0.11 Published 2010 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2990820 Disease Relevance 2.10 Pain Relevance 0.36
In summary, there is growing evidence that smoking influences tissue and cellular adhesion molecule expression profiles in several smoking-induced diseases: COPD; vascular diseases; and CIPD.
Regulation (influences) of Gene_expression (expression) of COPD associated with nicotine addiction, chronic obstructive pulmonary disease, periodontal disease, increased venous pressure under development, disease and adhesions
7) Confidence 0.08 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.04 Pain Relevance 0.07
Since toll-like receptor 4 (TLR-4) is crucial for effective response to LPS [37-39], studies are underway to investigate the role of this receptor in IL-8 expression in COPD.
Spec (investigate) Regulation (role) of Gene_expression (expression) of COPD associated with pulmonary disease
8) Confidence 0.05 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.39 Pain Relevance 0.12
This strategy is effective in murine models of COPD and in human subjects with COPD secondary to ?
Regulation (effective) of Gene_expression (models) of COPD associated with pulmonary disease
9) Confidence 0.04 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.79 Pain Relevance 0.16
This strategy is effective in murine models of COPD and in human subjects with COPD secondary to ?
Regulation (effective) of Gene_expression (subjects) of COPD associated with pulmonary disease
10) Confidence 0.04 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.80 Pain Relevance 0.16
Furthermore, in the present study no association between respiratory function indices and average ambient concentrations of any pollutants was observed among IHD cases, whereas effects of the fine fraction of ambient particulate on lung function among COPD subjects were detected, which had a strong a priori hypothesis.
Regulation (effects) of Gene_expression (subjects) of COPD in lung associated with pulmonary disease and coronary artery disease
11) Confidence 0.03 Published 2006 Journal Environ Health Section Body Doc Link PMC1475828 Disease Relevance 0.60 Pain Relevance 0

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