INT17969

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.03
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
RVLM 2
spinal cord 2
ventral 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 69 100.00 Very High Very High Very High
Somatostatin 23 100.00 Very High Very High Very High
Spinal cord 7 100.00 Very High Very High Very High
qutenza 7 99.98 Very High Very High Very High
antagonist 7 99.96 Very High Very High Very High
dopamine receptor 3 99.74 Very High Very High Very High
Rostral ventrolateral medulla 8 99.32 Very High Very High Very High
Chronic pancreatitis 6 98.52 Very High Very High Very High
Sciatic nerve 5 97.96 Very High Very High Very High
cerebral cortex 6 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Porphyria 3 99.92 Very High Very High Very High
Pancreatitis 6 98.52 Very High Very High Very High
Ganglion Cysts 1 93.80 High High
Paralysis 1 70.12 Quite High
Neuroblastoma 1 69.52 Quite High
Pain 1 63.68 Quite High
Vomiting 1 54.24 Quite High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral rhizotomy, but not cervical hemisection produced a significant but incomplete depletion of CCK and VIP immunoreactivity in dorsal, but not ventral horn.
Negative_regulation (depletion) of Regulation (immunoreactivity) of CCK in ventral associated with cholecystokinin
1) Confidence 0.43 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0.09 Pain Relevance 0.63
In all cases (n = 6 neurons in 6 individual rats), dizocilpine inhibited the effects of CCK, PBG, and PE on RVLM presympathetic neuronal discharge.
Negative_regulation (inhibited) of Regulation (effects) of CCK in RVLM associated with rostral ventrolateral medulla, porphyria and cholecystokinin
2) Confidence 0.43 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15155283 Disease Relevance 0.34 Pain Relevance 1.15
The present results indicate that the excitatory effect of CCK on the spinal cord is reduced after axotomy, suggesting that nerve section may induce transsynaptic changes in the spinal cord leading to hyposensitivity to CCK.
Negative_regulation (reduced) of Regulation (effect) of CCK in spinal cord associated with cholecystokinin and spinal cord
3) Confidence 0.43 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571648 Disease Relevance 0 Pain Relevance 0.96
Reviews describe the regulation of CCK gene expression and CCK release, the nature of the hormone binding site of the CCK A receptor, interaction of CCK, dopamine and GABA, the role of CCK in thermoregulation, sexual behavior and satiety in rodents and humans.
Negative_regulation (describe) of Regulation (regulation) of CCK associated with gaba and dopamine
4) Confidence 0.43 Published 2001 Journal Peptides Section Abstract Doc Link 11457511 Disease Relevance 0.13 Pain Relevance 0.24
In separate studies, we demonstrated that perivagal treatment with the sensory neurotoxin capsaicin impaired pancreatic responses to CCK-8 but had no effect on the inhibitory action of somatostatin-14 on pancreatic secretion evoked by 2-deoxy-D-glucose, ruling out an effect of somatostatin on the vagal afferent pathway.
Negative_regulation (impaired) of Regulation (responses) of CCK associated with qutenza and somatostatin
5) Confidence 0.41 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8103634 Disease Relevance 0 Pain Relevance 0.61
However, continued investigations with specific CCK receptor antagonists together with accurate measurements of circulating levels of CCK should make it possible to define the physiologic importance of CCK on these other potential sites of action.
Spec (possible) Negative_regulation (define) of Spec (possible) Regulation (importance) of CCK associated with antagonist
6) Confidence 0.41 Published 1989 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 2482253 Disease Relevance 0 Pain Relevance 0.21
In CP patients, the CCK secretory capacity was preserved, but the postprandial CCK response was reduced, depending on meal composition and the presence of exocrine insufficiency.
Negative_regulation (reduced) of Regulation (response) of CCK associated with cholecystokinin and chronic pancreatitis
7) Confidence 0.38 Published 1999 Journal Pancreas Section Abstract Doc Link 10438157 Disease Relevance 0.41 Pain Relevance 0.98
However, oral administration of PD 117302 abolished the effect of cholecystokinin on vasopressin release and reduced the subsequent rise in cortisol.
Negative_regulation (abolished) of Regulation (effect) of cholecystokinin associated with cholecystokinin
8) Confidence 0.34 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1957561 Disease Relevance 0.05 Pain Relevance 0.87
Sulpiride (SULP), a dopamine receptor antagonist, prevented the effects of APO and SOM, but not CCK-8, to inhibit [3H]ACh release.
Negative_regulation (prevented) of Regulation (effects) of CCK-8 associated with antagonist, dopamine receptor and somatostatin
9) Confidence 0.26 Published 1986 Journal Brain Res. Section Abstract Doc Link 2872939 Disease Relevance 0 Pain Relevance 0.98
NPY in a dose-dependent manner also reduced the neurally-mediated excitatory effect of cholecystokinin octapeptide (CCK8) sulfated form on this preparation.
Negative_regulation (reduced) of Regulation (effect) of CCK8 associated with cholecystokinin
10) Confidence 0.00 Published 1986 Journal Peptides Section Abstract Doc Link 2876416 Disease Relevance 0 Pain Relevance 0.42

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