INT179695

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 4.94
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP4F3) endoplasmic reticulum (CYP4F3)
Anatomy Link Frequency
blood 1
liver 1
CYP4F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 27 94.16 High High
bDMF 21 93.96 High High
Inflammation 70 92.44 High High
depression 147 91.60 High High
agonist 44 82.28 Quite High
cytokine 26 71.60 Quite High
Serotonin 3 63.48 Quite High
Kinase C 12 57.84 Quite High
Neurotransmitter 12 53.60 Quite High
Central nervous system 18 44.24 Quite Low
Disease Link Frequency Relevance Heat
Fatty Liver 252 99.08 Very High Very High Very High
Obesity 59 97.60 Very High Very High Very High
Liver Disease 72 96.48 Very High Very High Very High
Stress 66 93.44 High High
Metabolic Syndrome 92 92.72 High High
INFLAMMATION 66 92.44 High High
Depression 216 91.60 High High
Injury 32 87.08 High High
Nash(non-alcoholic Steatohepatitis) 108 83.92 Quite High
Disease Progression 12 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the 60–700 fold increase in mouse CYP4A mRNA during fasting [144] and 2–8 fold decrease in CYP4F mRNA further indicate the differential regulation of these distinct genes.
Negative_regulation (decrease) of CYP4F
1) Confidence 0.45 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.70 Pain Relevance 0.07
Furthermore, unlike the CYP4A genes that are induced in fatty liver, our preliminary data suggest that the mouse CYP4F genes may be repressed in mice fed a high fat diet and in the leptin-deficient ob/ob mice as a model of fatty liver disease (unpublished results).
Negative_regulation (repressed) of CYP4F in liver associated with liver disease, fatty liver and obesity
2) Confidence 0.45 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.63 Pain Relevance 0.04
transactivation, which may contribute to the suppression of the CYP4F genes during steatosis.

11.

Negative_regulation (suppression) of CYP4F
3) Confidence 0.33 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.27 Pain Relevance 0.05
activation, the CYP4F genes were reported to be repressed during fasting and by peroxisome proliferators possibly by PP-CoA or PUFA-CoA mediated inhibition of HNF4?
Negative_regulation (repressed) of CYP4F
4) Confidence 0.33 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.67 Pain Relevance 0.05
It is of relevance here because folic acid has been shown to increase omega-3 status when supplemented, and decrease omega-3 status when it is in deficiency in the animal model [63].
Negative_regulation (decrease) of omega-3
5) Confidence 0.05 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.91 Pain Relevance 0.24
A number of studies have found decreased omega-3 content in the blood of depressed patients [18-21].
Negative_regulation (decreased) of omega-3 in blood
6) Confidence 0.04 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.97 Pain Relevance 0.22
The epidemiological and laboratory studies, along with the research which shows depressed patients appear to have lowered omega-3 status, have naturally led to clinical investigations.
Negative_regulation (lowered) of omega-3
7) Confidence 0.04 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.79 Pain Relevance 0.72

General Comments

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