INT179696

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 37
Disease Relevance 16.79
Pain Relevance 9.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DAK) lyase activity (DAK)
Anatomy Link Frequency
brain 27
plasma 2
pituitary 1
cortex 1
ventral 1
DAK (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2708 99.70 Very High Very High Very High
Eae 134 99.54 Very High Very High Very High
Serotonin 505 98.80 Very High Very High Very High
dopamine receptor 33 98.12 Very High Very High Very High
Hippocampus 141 97.60 Very High Very High Very High
antidepressant 452 96.92 Very High Very High Very High
Nucleus accumbens 165 96.44 Very High Very High Very High
Dopamine 266 92.24 High High
medulla 33 87.64 High High
Inflammation 332 76.84 Quite High
Disease Link Frequency Relevance Heat
Depression 2220 99.70 Very High Very High Very High
Stress 356 99.64 Very High Very High Very High
Disease 228 99.48 Very High Very High Very High
Urological Neuroanatomy 100 99.02 Very High Very High Very High
Targeted Disruption 7 98.64 Very High Very High Very High
Post-partum Depression 1012 98.44 Very High Very High Very High
Suicidal Behaviour 339 93.16 High High
Cognitive Disorder 64 93.00 High High
Manic Depressive Disorder 9 91.24 High High
Neurodegenerative Disease 109 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With regard to DHA or a combination of EPA and DHA, there have been three negative reports.
Negative_regulation (combination) of DHA
1) Confidence 0.02 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 1.13 Pain Relevance 0.33
The preponderance of the literature indicates that changes in brain LC-PUFA status, particularly decreased DHA, are associated with both non-puerperal and postpartum depression.
Negative_regulation (decreased) of DHA in brain associated with depression and post-partum depression
2) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.28 Pain Relevance 0.20
While these reproduction-associated changes in brain fatty acid composition can be reversed by subsequent treatment with DHA (Figure 2), it is not yet known whether this restoration of brain fatty acid composition reverses the neurobiological changes that result from the loss of DHA (see below).

5.

Negative_regulation (loss) of DHA in brain
3) Confidence 0.02 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.46 Pain Relevance 0.23
In addition, both postpartum and virgin female rats with decreased brain DHA exhibited greater relative increases in corticosterone secretion over baseline when subjected to an intense stressor [49], although stressed corticosterone levels were not different between virgin females with decreased brain DHA and virgin females with normal brain DHA.
Negative_regulation (decreased) of DHA in brain
4) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.38 Pain Relevance 0.12
Postpartum rats with decreased brain DHA levels exhibited decreased density of D2-like dopamine receptors in the ventral striatum (nucleus accumbens and olfactory tubercle) [129].
Negative_regulation (decreased) of DHA in ventral associated with nucleus accumbens and dopamine receptor
5) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 1.07 Pain Relevance 0.66
This suggests that a loss of DHA from the adult brain contributes to dysregulation of the hypothalamic-pituitary-adrenal axis and that this effect may be more pronounced in the postpartum state.
Negative_regulation (loss) of DHA in pituitary
6) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.34 Pain Relevance 0.15
No alterations in hippocampal 5-HT1A binding were observed in virgin females with decreased brain DHA indicating that this represents an interaction of decreased brain DHA content with the postpartum state.
Negative_regulation (decreased) of DHA in brain
7) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.35 Pain Relevance 0.36
These effects of decreased brain DHA interact with the postpartum state such that the number of neurobiological alterations in postpartum rats with decreased brain DHA is greater than in virgin females with decreased brain DHA, and the magnitude of some of the alterations appears to be greater in the postpartum state.
Negative_regulation (decreased) of DHA in brain
8) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.25 Pain Relevance 0.18
Nevertheless, the increase in hippocampal 5-HT1A receptors may represent a unique effect of a loss of brain DHA in postpartum dams that may contribute specifically to the yet-to-be determined etiology of postpartum depression.
Negative_regulation (loss) of DHA in brain associated with depression and post-partum depression
9) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.46 Pain Relevance 0.38
Although brain fatty acid status has not been studied in humans after pregnancy, studies in rats indicated that the DHA content of brain phospholipids was reduced by roughly 25% after only a single reproductive cycle (i.e., pregnancy and lactation through weaning) if the animals were fed a diet low in n-3 PUFAs [47, 48].
Negative_regulation (reduced) of DHA in brain
10) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0 Pain Relevance 0
Furthermore, experimentally induced reductions in brain DHA content result in neurobiological alterations in rats similar to those observed in depressed humans.
Negative_regulation (reductions) of DHA in brain
11) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.27 Pain Relevance 0.19
These effects of decreased brain DHA interact with the postpartum state such that the number of neurobiological alterations in postpartum rats with decreased brain DHA is greater than in virgin females with decreased brain DHA, and the magnitude of some of the alterations appears to be greater in the postpartum state.
Negative_regulation (decreased) of DHA in brain
12) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.29 Pain Relevance 0.17
The majority of studies reported that maternal plasma DHA levels were decreased by as much as 50% in some individuals after a single pregnancy, and were not fully replenished at 26 weeks postpartum [40–44].
Negative_regulation (decreased) of DHA in plasma
13) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0 Pain Relevance 0
Animal studies indicate that decreased brain DHA in postpartum females leads to several depression-associated neurobiological changes including decreased hippocampal brain-derived neurotrophic factor and augmented hypothalamic-pituitary-adrenal responses to stress.
Negative_regulation (decreased) of DHA in brain associated with stress and depression
14) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Abstract Doc Link PMC2989696 Disease Relevance 0.51 Pain Relevance 0.21
Moreover, the physiological demands of pregnancy and lactation put childbearing women at particular risk of experiencing a loss of DHA from tissues including the brain, especially in individuals with inadequate dietary n-3 PUFA intake or suboptimal metabolic capabilities.
Negative_regulation (loss) of DHA in brain
15) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Abstract Doc Link PMC2989696 Disease Relevance 0.47 Pain Relevance 0.20
In addition, both postpartum and virgin female rats with decreased brain DHA exhibited greater relative increases in corticosterone secretion over baseline when subjected to an intense stressor [49], although stressed corticosterone levels were not different between virgin females with decreased brain DHA and virgin females with normal brain DHA.
Negative_regulation (decreased) of DHA in brain
16) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.24 Pain Relevance 0.07
Accordingly, decreased brain DHA, and perhaps other n-3 PUFAs, represents an important potential risk factor for depression generally, and postpartum depression in particular.
Negative_regulation (decreased) of DHA in brain associated with depression and post-partum depression
17) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.64 Pain Relevance 0.25
In the forced swim test, postpartum rats with decreased brain DHA content exhibited shorter latencies to immobility than postpartum rats with normal brain DHA levels [49].
Negative_regulation (decreased) of DHA in brain associated with eae
18) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.44 Pain Relevance 0.41
For example, in contrast to the effects of a loss of brain DHA in adult animals, either an increase or no change in the density of D2 receptors in the nucleus accumbens was observed in rats with inadequate accumulation of brain DHA during development, depending on the magnitude of the change in DHA [181–183].
Negative_regulation (loss) of DHA in brain associated with nucleus accumbens
19) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.41 Pain Relevance 0.42
This effect was not observed in virgin females with decreased brain DHA indicating that it represents an interaction of the decrease in brain DHA content with the postpartum state.
Negative_regulation (decrease) of DHA in brain
20) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.25 Pain Relevance 0.34

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