INT179697

Context Info Confidence 0.47 First Reported 2004 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 7 Disease Relevance 4.36 Pain Relevance 0.83

small molecule metabolic process (CYP4F3) endoplasmic reticulum (CYP4F3)

Anatomy Link Frequency liver 1 fat 1 capsules 1 CYP4F3 (Homo sapiens)

Pain Link Frequency Relevance Heat antidepressant 18 97.40 depression 98 91.76 Inflammation 70 91.00 chemokine 16 75.84 bDMF 14 71.52 cytokine 20 65.48 Dismenorea 4 28.60 Kinase C 12 17.52 fibrosis 44 5.00 agonist 44 5.00

Disease Link Frequency Relevance Heat Depression 144 98.68 Liver Disease 72 98.16 Repression 8 97.72 Iron Overload 4 96.24 Autoimmune Hepatitis 4 95.56 Cholangitis 4 94.68 Anxiety Disorder 10 94.20 Biliary Liver Cirrhosis 8 93.32 Disease 54 91.36 INFLAMMATION 66 91.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The differential regulation of the CYP4A and CYP4F genes by peroxisome proliferators, during fasting and by high fat diets indicates that these P450s may have distinct roles in lipid metabolism during the fasting and feeding cycles, and that different nuclear transcription factors regulate the expression of these genes (Figure 1).

Regulation (regulation) of CYP4F in fat

1) Confidence 0.47 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.95 Pain Relevance 0.10

It will be of significant importance to understand how the CYP4F genes are regulated by fatty acids and in animal models of fatty liver disease.

Regulation (regulated) of CYP4F in liver associated with liver disease

2) Confidence 0.47 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.07 Pain Relevance 0.22

This scenario is highly likely in the regulation of CYP4A and CYP4F genes since peroxisome proliferators (PP) activate PPAR?

Spec (likely) Regulation (regulation) of CYP4F

3) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.09 Pain Relevance 0

For instance, the differential regulation of the CYP4A and CYP4F genes may be determined by cross-talk between PPAR?

Regulation (regulation) of CYP4F

4) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.10 Pain Relevance 0

Dietary antioxidants are known to influence the antioxidant defense system, and new research suggests that dietary antioxidants can influence omega-3 status.

Regulation (influence) of omega-3

5) Confidence 0.04 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.94 Pain Relevance 0.24

In this study the patients who received the omega-3 fish oil capsules had a significantly decreased score on the HRSD compared to those taking the placebo.

Regulation (received) of omega-3 in capsules

6) Confidence 0.04 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.90 Pain Relevance 0.28

These levels reflect a mixture of diet and metabolism since the essential FAs (omega-3 and omega-6) are strongly affected by diet whereas palmitic and stearic, which can be synthesized de novo, reflect metabolic processes.

Regulation (affected) of omega-3

7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2673680 Disease Relevance 0.32 Pain Relevance 0

General Comments

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