INT179698

Context Info Confidence 0.54 First Reported 2004 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 11 Disease Relevance 3.86 Pain Relevance 0.91

small molecule metabolic process (CYP4F3) endoplasmic reticulum (CYP4F3)

Anatomy Link Frequency capsules 2 blood 1 plasma 1 white blood cells 1 fat 1 CYP4F3 (Homo sapiens)

Pain Link Frequency Relevance Heat depression 147 98.16 antidepressant 27 96.04 Inflammation 22 87.24 Neurobehavioral 3 79.60 chemokine 4 72.08 Central nervous system 18 65.36 cytokine 20 61.72 bDMF 21 8.72 Neurotransmitter 12 5.00 fibrosis 11 5.00

Disease Link Frequency Relevance Heat Liver Disease 18 99.60 Depression 216 98.16 Lung Cancer 3 93.32 Iron Overload 1 92.48 Autoimmune Hepatitis 1 91.80 Cholangitis 1 90.92 Biliary Liver Cirrhosis 2 89.56 Obesity 26 88.88 Disease 20 87.60 INFLAMMATION 21 87.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whether induction of CYP4F long chain fatty acid ?

Positive_regulation (induction) of CYP4F

1) Confidence 0.54 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.98 Pain Relevance 0.21

The increase of total omega 3 content in the RBCs was linearly related to consumption of the omega 3 supplement.

Positive_regulation (increase) of omega 3

2) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0.17 Pain Relevance 0

It is of relevance here because folic acid has been shown to increase omega-3 status when supplemented, and decrease omega-3 status when it is in deficiency in the animal model [63].

Positive_regulation (increase) of omega-3

3) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.89 Pain Relevance 0.24

Interestingly, 25 mg of zinc supplemented for two months has also been shown to significantly increase omega-3 status in the plasma phospholipids at the expense of saturated fat [58].

Positive_regulation (increase) of omega-3 in fat

4) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.61 Pain Relevance 0.18

Two studies have actually shown significant increases in plasma and RBC omega-3 status among depressed patients [32,33].

Positive_regulation (increases) of omega-3 in plasma

5) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.95 Pain Relevance 0.28

Incorporation of the omega 3 fatty acids into cell membranes is required for the activity of the omega 3.

Positive_regulation (required) of omega 3

6) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0

On the other hand, the fatty acid composition of the WBCs, obtained from the same blood specimen as the RBCs did not show a dose responsive increase in omega 3 fatty acids.

Positive_regulation (increase) of omega 3 in blood

7) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0.13 Pain Relevance 0

There were significant, dose responsive increases in the omega 3 fatty acids: EPA (slope 0.4924 ± 0.01134, p = 0.0005, r2 = 0.99), DPA (slope 0.4690 ± 0.03361, p = 0.005, r2 = 0.99) and DHA (slope 0.3593 ± 0.04765, p = 0.017, r2 = 0.97).

Positive_regulation (increases) of omega 3

8) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0

There was a linear, dose responsive increase in the fraction of omega 3 fatty acids in red blood cells but the increase in omega 3 in white blood cells was not linear.

Positive_regulation (increase) of omega 3 in white blood cells

9) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2846941 Disease Relevance 0.13 Pain Relevance 0

We do not know if more than 9 capsules per day would result in another increase in omega 3 in the WBCs.

Positive_regulation (increase) of omega 3 in capsules

10) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0

However, the results shown here indicate that 9 capsules per day did not result in more omega 3 in WBCs than did 6 capsules per day for one month.

Neg (not) Positive_regulation (result) of omega 3 in capsules

11) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0

General Comments

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