INT179698

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 3.86
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP4F3) endoplasmic reticulum (CYP4F3)
Anatomy Link Frequency
capsules 2
blood 1
plasma 1
white blood cells 1
fat 1
CYP4F3 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 147 98.16 Very High Very High Very High
antidepressant 27 96.04 Very High Very High Very High
Inflammation 22 87.24 High High
Neurobehavioral 3 79.60 Quite High
chemokine 4 72.08 Quite High
Central nervous system 18 65.36 Quite High
cytokine 20 61.72 Quite High
bDMF 21 8.72 Low Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 18 99.60 Very High Very High Very High
Depression 216 98.16 Very High Very High Very High
Lung Cancer 3 93.32 High High
Iron Overload 1 92.48 High High
Autoimmune Hepatitis 1 91.80 High High
Cholangitis 1 90.92 High High
Biliary Liver Cirrhosis 2 89.56 High High
Obesity 26 88.88 High High
Disease 20 87.60 High High
INFLAMMATION 21 87.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether induction of CYP4F long chain fatty acid ?
Positive_regulation (induction) of CYP4F
1) Confidence 0.54 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.98 Pain Relevance 0.21
The increase of total omega 3 content in the RBCs was linearly related to consumption of the omega 3 supplement.
Positive_regulation (increase) of omega 3
2) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0.17 Pain Relevance 0
It is of relevance here because folic acid has been shown to increase omega-3 status when supplemented, and decrease omega-3 status when it is in deficiency in the animal model [63].
Positive_regulation (increase) of omega-3
3) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.89 Pain Relevance 0.24
Interestingly, 25 mg of zinc supplemented for two months has also been shown to significantly increase omega-3 status in the plasma phospholipids at the expense of saturated fat [58].
Positive_regulation (increase) of omega-3 in fat
4) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.61 Pain Relevance 0.18
Two studies have actually shown significant increases in plasma and RBC omega-3 status among depressed patients [32,33].
Positive_regulation (increases) of omega-3 in plasma
5) Confidence 0.06 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 0.95 Pain Relevance 0.28
Incorporation of the omega 3 fatty acids into cell membranes is required for the activity of the omega 3.
Positive_regulation (required) of omega 3
6) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0
On the other hand, the fatty acid composition of the WBCs, obtained from the same blood specimen as the RBCs did not show a dose responsive increase in omega 3 fatty acids.
Positive_regulation (increase) of omega 3 in blood
7) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0.13 Pain Relevance 0
There were significant, dose responsive increases in the omega 3 fatty acids: EPA (slope 0.4924 ± 0.01134, p = 0.0005, r2 = 0.99), DPA (slope 0.4690 ± 0.03361, p = 0.005, r2 = 0.99) and DHA (slope 0.3593 ± 0.04765, p = 0.017, r2 = 0.97).
Positive_regulation (increases) of omega 3
8) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0
There was a linear, dose responsive increase in the fraction of omega 3 fatty acids in red blood cells but the increase in omega 3 in white blood cells was not linear.
Positive_regulation (increase) of omega 3 in white blood cells
9) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2846941 Disease Relevance 0.13 Pain Relevance 0
We do not know if more than 9 capsules per day would result in another increase in omega 3 in the WBCs.
Positive_regulation (increase) of omega 3 in capsules
10) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0
However, the results shown here indicate that 9 capsules per day did not result in more omega 3 in WBCs than did 6 capsules per day for one month.
Neg (not) Positive_regulation (result) of omega 3 in capsules
11) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846941 Disease Relevance 0 Pain Relevance 0

General Comments

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