INT17974

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 34
Total Number 37
Disease Relevance 4.45
Pain Relevance 12.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
uterine 10
neurons 4
embryo 2
CSF 2
neurohypophysis 2
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 24 100.00 Very High Very High Very High
narcan 60 99.98 Very High Very High Very High
Morphine 20 99.98 Very High Very High Very High
antagonist 15 99.90 Very High Very High Very High
Endogenous opioid 13 99.74 Very High Very High Very High
Opioid 47 99.68 Very High Very High Very High
Pain 76 98.02 Very High Very High Very High
Action potential 4 97.68 Very High Very High Very High
Dynorphin 1 97.68 Very High Very High Very High
Enkephalin 6 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 24 100.00 Very High Very High Very High
Pre-term Labor 4 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 4 99.20 Very High Very High Very High
Pain 75 98.02 Very High Very High Very High
Targeted Disruption 1 97.66 Very High Very High Very High
Stress 15 95.08 Very High Very High Very High
Anxiety Disorder 2 82.88 Quite High
Peripheral Arterial Disease 2 81.72 Quite High
Birth Weight 1 75.96 Quite High
Premature Birth 2 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oxytocin secretion from the posterior pituitary gland is increased during parturition, stimulated by the uterine contractions that forcefully expel the fetuses.
Positive_regulation (increased) of Localization (secretion) of Oxytocin in uterine associated with dismenorea
1) Confidence 0.69 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.10 Pain Relevance 0.20
During parturition, oxytocin cells increase their basal activity, and hence oxytocin secretion increases.
Positive_regulation (increase) of Localization (secretion) of oxytocin
2) Confidence 0.69 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.06 Pain Relevance 0.50
Boar contact does not induce oxytocin release during the period of embryo migration in sows.
Neg (not) Positive_regulation (induce) of Localization (release) of oxytocin in embryo
3) Confidence 0.68 Published 2006 Journal Reprod. Domest. Anim. Section Title Doc Link 16689888 Disease Relevance 0.09 Pain Relevance 0.09
Thus, oxytocin secretion is increased during preterm labor, and the release of prostaglandin F is also increased.
Positive_regulation (increased) of Localization (secretion) of oxytocin associated with pre-term labor
4) Confidence 0.68 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7148897 Disease Relevance 0.34 Pain Relevance 0.09
Breast-stimulated uterine contractions have been assumed to be mediated through oxytocin release.
Positive_regulation (mediated) of Localization (release) of oxytocin in uterine associated with dismenorea
5) Confidence 0.68 Published 1986 Journal Am J Perinatol Section Abstract Doc Link 3942612 Disease Relevance 0.44 Pain Relevance 0.17
In the horse mare, the onset of parturition is associated with an increase in oxytocin secretion, and it has been suggested that the onset of parturition may be triggered by endogenous oxytocin release.
Positive_regulation (increase) of Localization (secretion) of oxytocin
6) Confidence 0.68 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.23
Vaginocervical stimulation resulted in a significant increase in oxytocin secretion in all mares.
Positive_regulation (increase) of Localization (secretion) of oxytocin
7) Confidence 0.68 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.36
The presence of a boar, rather than the act of mating, induces central oxytocin release in the sow and thus increases uterine activity.
Positive_regulation (induces) of Localization (release) of oxytocin in uterine
8) Confidence 0.59 Published 2005 Journal Theriogenology Section Abstract Doc Link 15626413 Disease Relevance 0.18 Pain Relevance 0.18
The purpose of the present studies was to determine whether cells in the hypothalamic paraventricular (PVN) or supraoptic (SON) nuclei mediate the serotonergic stimulation of oxytocin secretion.
Spec (whether) Positive_regulation (stimulation) of Localization (secretion) of oxytocin
9) Confidence 0.58 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7882048 Disease Relevance 0 Pain Relevance 0.07
Hypothalamic paraventricular, but not supraoptic neurons, mediate the serotonergic stimulation of oxytocin secretion.
Positive_regulation (stimulation) of Localization (secretion) of oxytocin in neurons
10) Confidence 0.58 Published 1995 Journal Brain Res. Bull. Section Title Doc Link 7882048 Disease Relevance 0 Pain Relevance 0.08
Furthermore, the 5-HT uptake blocker fluoxetine (10 mg/kg, IP) blocked the effects of both p-chloroamphetamine and d-fenfluramine on plasma oxytocin concentrations, suggesting that both 5-HT releasers must be taken up through the 5-HT transporter into 5-HT nerve terminals to increase oxytocin secretion.
Positive_regulation (increase) of Localization (secretion) of oxytocin in nerve associated with fluoxetine
11) Confidence 0.58 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7882048 Disease Relevance 0 Pain Relevance 0.10
Addition of 5 microM naloxone, 1 min prior to the addition of the stimulus, caused a significant (p < 0.025) increase of oxytocin release.
Positive_regulation (increase) of Localization (release) of oxytocin associated with narcan
12) Confidence 0.53 Published 1994 Journal Neuroreport Section Abstract Doc Link 7827343 Disease Relevance 0 Pain Relevance 0.75
We conclude that vaginocervical stimulation leads to the selective release of oxytocin from the neurohypophysis without affecting concentrations of oxytocin in the CSF.
Positive_regulation (leads) of Localization (release) of oxytocin in CSF
13) Confidence 0.51 Published 1987 Journal J. Endocrinol. Section Abstract Doc Link 3437251 Disease Relevance 0 Pain Relevance 0.42
Each burst causes the secretion of a pulse of oxytocin, which sharply increases uterine tone; these bursts depend upon auto-stimulation by oxytocin released from the dendrites of the magnocellular neurons in the supraoptic and paraventricular nuclei.
Positive_regulation (causes) of Localization (secretion) of oxytocin in neurons
14) Confidence 0.50 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.05 Pain Relevance 0.48
To test the hypothesis that oxytocin secretion is regulated by endogenous opioids in the periparturient period, we have 1) characterized oxytocin secretion in response to vaginocervical stimulation and 2) determined the effect of naloxone, an opioid antagonist, on oxytocin secretion induced by vaginocervical stimulation in prepartum mares and in postpartum mares at estrus and diestrus.
Positive_regulation (induced) of Localization (secretion) of oxytocin associated with antagonist, narcan, endogenous opioid and opioid
15) Confidence 0.49 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.33
We hypothesize that this forward shift in the initiation of the estradiol surge induces nocturnal uterine contractions by oxytocin release and/or increase in uterine oxytocin receptors and generates molecular messages that are the genesis for labor and delivery in the baboon.
Positive_regulation (increase) of Localization (release) of oxytocin in uterine associated with dismenorea
16) Confidence 0.49 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1957886 Disease Relevance 0.29 Pain Relevance 0.33
During the postpartum period, total amount of oxytocin secreted following vaginocervical stimulation tended to be greater than during the prepartum period, and stimulated oxytocin secretion was significantly greater in naloxone-treated mares than in saline-treated mares.
Positive_regulation (stimulated) of Localization (secretion) of oxytocin associated with narcan
17) Confidence 0.49 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.38
We hypothesize that this forward shift in the initiation of the estradiol surge induces nocturnal uterine contractions by oxytocin release and/or increase in uterine oxytocin receptors and generates molecular messages that are the genesis for labor and delivery in the baboon.
Positive_regulation (induces) of Localization (release) of oxytocin in uterine associated with dismenorea
18) Confidence 0.49 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1957886 Disease Relevance 0.29 Pain Relevance 0.34
Likewise, induced onset of labor and use of oxytocin were significantly related (x2 = 61.6, p < 0.001) and for this reason, only spontaneous onset of labor was used in the final model.
Positive_regulation (induced) of Localization (use) of oxytocin
19) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.40 Pain Relevance 0.14
Therefore, despite evidence in oxytocin knockout mice that oxytocin is not essential for parturition in this species, the results of the present study indicate that oxytocin neurone activity and secretion contribute to the birth process in normal mice.
Positive_regulation (contribute) of Localization (secretion) of oxytocin associated with targeted disruption
20) Confidence 0.47 Published 2002 Journal Reproduction Section Abstract Doc Link 11914117 Disease Relevance 0.41 Pain Relevance 0.50

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