INT17975

Context Info Confidence 0.69 First Reported 1989 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 12 Disease Relevance 1.72 Pain Relevance 3.72

plasma membrane (OXTR) signal transducer activity (OXTR)

Anatomy Link Frequency brain 6 neurons 2 organ systems 2 hippocampus 2 OXTR (Homo sapiens)

Pain Link Frequency Relevance Heat Endogenous opioid 1 100.00 Cholecystokinin 12 99.36 excitatory amino acid 5 99.28 opioid receptor 3 99.10 Acupuncture 10 99.00 Dopamine 8 98.80 epidural 3 98.36 Hippocampus 2 97.56 Opioid 10 96.46 analgesia 6 96.40

Disease Link Frequency Relevance Heat Stress 42 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 2 91.84 Pain 19 90.88 Erectile Dysfunction 9 88.00 Reprotox - General 3 4 84.80 Disease 4 75.00 Dysmenorrhea 4 55.72 Mental Disorders 4 50.00 Injury 40 30.32 Weight Gain 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hence, an increased oxytocin secretion rate is not a necessary prerequisite for oxytocin-stimulated contractions during labor.

Positive_regulation (increased) of Localization (secretion) of oxytocin

1) Confidence 0.69 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.08

Presently, there is little evidence for an increased maternal secretion rate of oxytocin at the onset of labor, but during labor a progressive increase occurs, with a maximum at the expulsive phase.

Positive_regulation (increased) of Localization (secretion) of oxytocin

2) Confidence 0.69 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.05

Vaginocervical stimulation increases the release of oxytocin into cerebrospinal fluid and in-vivo microdialysis has revealed high levels of oxytocin release in limbic brain areas known to be important for maternal behaviour.

Positive_regulation (increases) of Localization (release) of oxytocin in brain

3) Confidence 0.54 Published 1994 Journal Acta Paediatr Suppl Section Abstract Doc Link 7981474 Disease Relevance 0 Pain Relevance 0.15

Both exercise and acupuncture produce rhythmic discharges in nerve fibres, and cause the release of endogenous opioids and oxytocin essential to the induction of functional changes in different organ systems.

Positive_regulation (cause) of Localization (release) of oxytocin in organ systems associated with endogenous opioid and acupuncture

4) Confidence 0.53 Published 1995 Journal Med. Hypotheses Section Abstract Doc Link 8569551 Disease Relevance 0.49 Pain Relevance 0.85

Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women.

Positive_regulation (increase) of Localization (secretion) of Oxytocin

5) Confidence 0.50 Published 1991 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 1957888 Disease Relevance 0.06 Pain Relevance 0.06

Presently, there is little evidence for an increased maternal secretion rate of oxytocin at the onset of labor, but during labor a progressive increase occurs, with a maximum at the expulsive phase.

Positive_regulation (increased) of Localization (rate) of oxytocin

6) Confidence 0.47 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.05

Although ineffective when given alone, opioids potentiate the release of oxytocin in the limbic brain and increase the intensity of maternal responding, while the opioid receptor blocker, naltrexone, prevents both maternal induction and oxytocin release.

Positive_regulation (induction) of Localization (release) of oxytocin in brain associated with opioid receptor and opioid

7) Confidence 0.45 Published 1994 Journal Acta Paediatr Suppl Section Abstract Doc Link 7981474 Disease Relevance 0 Pain Relevance 0.18

Vaginocervical stimulation increases the release of oxytocin into cerebrospinal fluid and in-vivo microdialysis has revealed high levels of oxytocin release in limbic brain areas known to be important for maternal behaviour.

Positive_regulation (levels) of Localization (release) of oxytocin in brain

8) Confidence 0.42 Published 1994 Journal Acta Paediatr Suppl Section Abstract Doc Link 7981474 Disease Relevance 0 Pain Relevance 0.16

NO in turn activates, by a mechanism that is as yet unidentified, the release of oxytocin from oxytocinergic neurons in extrahypothalamic brain areas.

Positive_regulation (activates) of Localization (release) of oxytocin in neurons

9) Confidence 0.39 Published 2003 Journal Curr Drug Targets Section Abstract Doc Link 12528990 Disease Relevance 0.45 Pain Relevance 0.69

However, breastfeeding can assist adoptive mothers by stimulating the release of oxytocin, prolactin and cholecystokinin and requiring mothers to maintain physical proximity to their child.

Positive_regulation (stimulating) of Localization (release) of oxytocin associated with cholecystokinin

10) Confidence 0.35 Published 2006 Journal Int Breastfeed J Section Body Doc Link PMC1459116 Disease Relevance 0.16 Pain Relevance 0.05

When activated by dopamine, excitatory amino acids and oxytocin itself, these neurons facilitate yawning by releasing oxytocin at sites distant form the paraventricular nucleus, i.e. the hippocampus, the pons and/or the medulla oblongata.

Positive_regulation (facilitate) of Localization (releasing) of oxytocin in hippocampus associated with medulla, dopamine, hippocampus and excitatory amino acid

11) Confidence 0.34 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9551709 Disease Relevance 0.06 Pain Relevance 0.63

Finally, breastfeeding involves intimate social interaction between mother and child, which may result in the release of the anti-stress hormone oxytocin [26,27].

Positive_regulation (result) of Localization (release) of oxytocin associated with stress

12) Confidence 0.20 Published 2006 Journal Int Breastfeed J Section Body Doc Link PMC1459116 Disease Relevance 0.51 Pain Relevance 0.76

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