INT179750
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
A report that EAAT2 expression (Western blot and RT-PCR) is reduced in AQP4-null astrocytes (8) prompted us to evaluate glutamate toxicity as a potential outcome of IgG-induced AQP4 modulation. | |||||||||||||||
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A recent report that astrocytes lacking AQP4 express a reduced level of the astrocytic Na+-dependent excitatory amino acid transporter 2 (EAAT2; homologue of rodent GLT-1 [8]) led us to hypothesize that if NMO-IgG altered the expression of EAAT2 in astrocyte membranes, this might impair glutamate homeostasis (6). | |||||||||||||||
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Recently, Wang and coworkers [22] showed a reduced expression of GLT-1 and GLAST, and also, an impaired glutamate transport in human primary astrocytes, by TNF-?. | |||||||||||||||
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Recently, Wang and coworkers [22] showed a reduced expression of GLT-1 and GLAST, and also, an impaired glutamate transport in human primary astrocytes, by TNF-?. | |||||||||||||||
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General Comments
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