INT179750

Context Info Confidence 0.45 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 3.05 Pain Relevance 2.15

plasma membrane (SLC1A2) transmembrane transport (SLC1A2)

Anatomy Link Frequency astrocytes 8 SLC1A2 (Homo sapiens)

Pain Link Frequency Relevance Heat excitatory amino acid 4 100.00 Glutamate 244 98.64 Inflammation 16 98.40 Central nervous system 46 97.88 Inflammatory response 4 97.68 Demyelination 4 92.08 Glutamate receptor 12 87.00 cytokine 40 73.64 adenocard 4 60.76 Multiple sclerosis 30 60.72

Disease Link Frequency Relevance Heat Demyelinating Disease 44 99.36 INFLAMMATION 20 98.40 Neuromyelitis Optica 174 97.96 Toxicity 10 97.48 Stress 10 96.04 Autoimmune Disease 6 94.20 Neurodegenerative Disease 14 79.84 Necrosis 8 74.24 Cancer 6 73.88 Alzheimer's Dementia 2 55.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A report that EAAT2 expression (Western blot and RT-PCR) is reduced in AQP4-null astrocytes (8) prompted us to evaluate glutamate toxicity as a potential outcome of IgG-induced AQP4 modulation.

Negative_regulation (reduced) of Gene_expression (expression) of EAAT2 in astrocytes associated with toxicity and glutamate

1) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.97 Pain Relevance 0.63

A recent report that astrocytes lacking AQP4 express a reduced level of the astrocytic Na+-dependent excitatory amino acid transporter 2 (EAAT2; homologue of rodent GLT-1 [8]) led us to hypothesize that if NMO-IgG altered the expression of EAAT2 in astrocyte membranes, this might impair glutamate homeostasis (6).

Negative_regulation (reduced) of Gene_expression (express) of EAAT2 in astrocyte associated with neuromyelitis optica, glutamate and excitatory amino acid

2) Confidence 0.33 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 1.33 Pain Relevance 0.47

Recently, Wang and coworkers [22] showed a reduced expression of GLT-1 and GLAST, and also, an impaired glutamate transport in human primary astrocytes, by TNF-?.

Negative_regulation (reduced) of Gene_expression (expression) of GLT-1 in astrocytes associated with glutamate

3) Confidence 0.08 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.38 Pain Relevance 0.53

Recently, Wang and coworkers [22] showed a reduced expression of GLT-1 and GLAST, and also, an impaired glutamate transport in human primary astrocytes, by TNF-?.

Negative_regulation (showed) of Gene_expression (expression) of GLT-1 in astrocytes associated with glutamate

4) Confidence 0.08 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.38 Pain Relevance 0.53

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