INT179750

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.05
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC1A2) transmembrane transport (SLC1A2)
Anatomy Link Frequency
astrocytes 8
SLC1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
excitatory amino acid 4 100.00 Very High Very High Very High
Glutamate 244 98.64 Very High Very High Very High
Inflammation 16 98.40 Very High Very High Very High
Central nervous system 46 97.88 Very High Very High Very High
Inflammatory response 4 97.68 Very High Very High Very High
Demyelination 4 92.08 High High
Glutamate receptor 12 87.00 High High
cytokine 40 73.64 Quite High
adenocard 4 60.76 Quite High
Multiple sclerosis 30 60.72 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 44 99.36 Very High Very High Very High
INFLAMMATION 20 98.40 Very High Very High Very High
Neuromyelitis Optica 174 97.96 Very High Very High Very High
Toxicity 10 97.48 Very High Very High Very High
Stress 10 96.04 Very High Very High Very High
Autoimmune Disease 6 94.20 High High
Neurodegenerative Disease 14 79.84 Quite High
Necrosis 8 74.24 Quite High
Cancer 6 73.88 Quite High
Alzheimer's Dementia 2 55.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A report that EAAT2 expression (Western blot and RT-PCR) is reduced in AQP4-null astrocytes (8) prompted us to evaluate glutamate toxicity as a potential outcome of IgG-induced AQP4 modulation.
Negative_regulation (reduced) of Gene_expression (expression) of EAAT2 in astrocytes associated with toxicity and glutamate
1) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.97 Pain Relevance 0.63
A recent report that astrocytes lacking AQP4 express a reduced level of the astrocytic Na+-dependent excitatory amino acid transporter 2 (EAAT2; homologue of rodent GLT-1 [8]) led us to hypothesize that if NMO-IgG altered the expression of EAAT2 in astrocyte membranes, this might impair glutamate homeostasis (6).
Negative_regulation (reduced) of Gene_expression (express) of EAAT2 in astrocyte associated with neuromyelitis optica, glutamate and excitatory amino acid
2) Confidence 0.33 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 1.33 Pain Relevance 0.47
Recently, Wang and coworkers [22] showed a reduced expression of GLT-1 and GLAST, and also, an impaired glutamate transport in human primary astrocytes, by TNF-?.
Negative_regulation (reduced) of Gene_expression (expression) of GLT-1 in astrocytes associated with glutamate
3) Confidence 0.08 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.38 Pain Relevance 0.53
Recently, Wang and coworkers [22] showed a reduced expression of GLT-1 and GLAST, and also, an impaired glutamate transport in human primary astrocytes, by TNF-?.
Negative_regulation (showed) of Gene_expression (expression) of GLT-1 in astrocytes associated with glutamate
4) Confidence 0.08 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.38 Pain Relevance 0.53

General Comments

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