INT179752

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.35
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC1A3) transmembrane transport (SLC1A3)
Anatomy Link Frequency
cerebellum 2
microglia 2
SLC1A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 113 100.00 Very High Very High Very High
adenocard 2 97.28 Very High Very High Very High
nMDA receptor 38 92.80 High High
agonist 9 81.64 Quite High
antagonist 15 80.36 Quite High
Locus ceruleus 2 79.92 Quite High
Multiple sclerosis 8 76.72 Quite High
Glutamate receptor 10 74.44 Quite High
noradrenaline 5 73.84 Quite High
cytokine 23 69.96 Quite High
Disease Link Frequency Relevance Heat
Autism 314 99.68 Very High Very High Very High
Disease 16 98.80 Very High Very High Very High
Aging 1 96.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 15 94.40 High High
Toxicity 47 91.04 High High
Cognitive Disorder 54 90.80 High High
Fatigue 48 87.52 High High
Drug Induced Neurotoxicity 39 87.12 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 89 86.56 High High
Dementia 22 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GLAST glutamate aspartate transporter
Positive_regulation (transporter) of Gene_expression (transporter) of GLAST associated with glutamate
1) Confidence 0.17 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC533886 Disease Relevance 0.77 Pain Relevance 0.66
Furthermore, both the mRNA and protein levels of EAAT 1 and EAAT 2 were found to be significantly increased in the autistic cerebellum (Purcell et al., 2001).
Positive_regulation (increased) of Gene_expression (levels) of EAAT 1 in cerebellum associated with autism
2) Confidence 0.04 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.39 Pain Relevance 0.43
Activated microglia express the glutamate transporter EAAT-1 and the density of this transporter increases with progression through the disease process.
Positive_regulation (increases) of Gene_expression (express) of EAAT-1 in microglia associated with glutamate and disease
3) Confidence 0.02 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.19 Pain Relevance 0.47

General Comments

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