INT179759

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 5.38
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelial cells 2
colon 1
IGKV2D-19 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 6 77.44 Quite High
agonist 5 25.16 Quite Low
positron emission tomography 20 13.52 Low Low
headache 20 5.00 Very Low Very Low Very Low
peripheral neuropathy 10 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 190 99.84 Very High Very High Very High
Death 20 98.72 Very High Very High Very High
Gastrointestinal Neoplasms 5 98.20 Very High Very High Very High
Toxicity 40 91.12 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 85.84 High High
Skin Cancer 55 84.84 Quite High
Diarrhoea 30 83.76 Quite High
Disease 72 79.04 Quite High
Depression 7 77.44 Quite High
Neutropenia 10 58.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the longer versions of the GHQ are normally considered multidimensional, the GHQ-12 is often regarded as measuring only a single dimension of psychological health.
Gene_expression (regarded) of GHQ-12
1) Confidence 0.46 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC534792 Disease Relevance 0.23 Pain Relevance 0.04
RAAG12 is only expressed on epithelial cells lining the gastrointestinal (GI) tract; immunohistochemistry studies reveal diffuse membrane expression of RAAG12 in human GI cancer cells.
Gene_expression (expression) of RAAG12 in epithelial cells associated with cancer
2) Confidence 0.01 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.19 Pain Relevance 0
RAAG12 is only expressed on epithelial cells lining the gastrointestinal (GI) tract; immunohistochemistry studies reveal diffuse membrane expression of RAAG12 in human GI cancer cells.
Gene_expression (expressed) of RAAG12 in epithelial cells associated with cancer
3) Confidence 0.01 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.38 Pain Relevance 0
Lewis et al. presented preliminary phase I data on 53 patients, most of whom had GI cancers (colon, pancreatic, gastroesophageal) and all of whom demonstrated greater than 10% expression of RAAG12 on tumor specimens (whether these were original pathology specimens or biopsies taken at start of trial was not specified) [8].
Gene_expression (expression) of RAAG12 in colon associated with cancer
4) Confidence 0.01 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.92 Pain Relevance 0
Binding of RAV12 to RAAG12 induces tumor cell death via oncolysis (direct cell death); in preclinical animal xenograft models only tumor cell lines expressing RAAG12 (at least 10% of cells) demonstrated any response [7].
Gene_expression (expressing) of RAAG12 associated with cancer and death
5) Confidence 0.01 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.03 Pain Relevance 0
For example, patient selection for the RAV12 antibody was limited to those patients whose tumor specimens demonstrated at least 10% expression of its target RAAG12, although what proportion of total screened gastrointestinal cancer patients showed this level of expression was not presented and would be of interest.
Gene_expression (expression) of RAAG12 associated with cancer and gastrointestinal neoplasms
6) Confidence 0.01 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.43 Pain Relevance 0

General Comments

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