INT179760

Context Info Confidence 0.25 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 6.10 Pain Relevance 0.98

Anatomy Link Frequency Impression 1 lung 1 IGKV2D-19 (Homo sapiens)

Pain Link Frequency Relevance Heat spastic colon 108 100.00 depression 30 98.24 Pain 10 5.00 abdominal pain 2 5.00 Fibrositis 1 5.00 nud 1 5.00

Disease Link Frequency Relevance Heat Dyspnea 315 100.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 107 100.00 Manic Depressive Disorder 5 99.76 Anxiety Disorder 70 99.24 Depression 40 98.24 Affective Disorder 12 98.24 Pulmonary Disease 30 98.20 Hypertension 16 95.52 Diabetes Mellitus 16 94.16 Mental Disorders 14 83.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Pearson's correlation coefficient (r) was used to assess the association between GHQ-12 scores and various variables, namely Beck Anxiety Inventory, Clinical Global Impression and SF-36 scores.

GHQ-12 Binding (association) of in Impression associated with anxiety disorder

1) Confidence 0.25 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC534792 Disease Relevance 0.15 Pain Relevance 0

Mean Dyspnoea-12 score was strongly associated with HADS scores (anxiety r?

Dyspnoea-12 Binding (associated) of associated with anxiety disorder and dyspnea

2) Confidence 0.21 Published 2010 Journal Thorax Section Body Doc Link PMC2795166 Disease Relevance 1.16 Pain Relevance 0.10

Interview participants rated the Dyspnoea-12 as easy to complete (median?

Dyspnoea-12 Binding (complete) of associated with dyspnea

3) Confidence 0.21 Published 2010 Journal Thorax Section Body Doc Link PMC2795166 Disease Relevance 1.22 Pain Relevance 0.09

During a routine clinic visit participants completed the Dyspnoea-12, MRC dyspnoea scale,8 Hospital Anxiety and Depression Scale (HADS),30 lung function tests and 6-minute walk distance (6MWD).

Dyspnoea-12 Binding (completed) of in lung associated with depression, anxiety disorder and dyspnea

4) Confidence 0.21 Published 2010 Journal Thorax Section Body Doc Link PMC2795166 Disease Relevance 1.62 Pain Relevance 0.05

The association with IBS and symptoms load (GHQ-12) followed a curved dose response pattern.

GHQ-12 Binding (association) of associated with spastic colon

5) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2928181 Disease Relevance 1.28 Pain Relevance 0.75

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