INT179763

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.72
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apob) transport (Apob) extracellular space (Apob)
extracellular region (Apob) endoplasmic reticulum (Apob) enzyme binding (Apob)
Anatomy Link Frequency
liver 1
Apob (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 7 60.00 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 129 100.00 Very High Very High Very High
Hypertriglyceridemia 1 98.96 Very High Very High Very High
Hyperlipidemia 85 98.14 Very High Very High Very High
Cardiovascular Disease 85 92.72 High High
Diabetes Mellitus 120 88.48 High High
Obesity 25 76.16 Quite High
Dyslipidemia /

Combined Dyslipidemia

10 75.12 Quite High
Coronary Artery Disease 12 70.56 Quite High
Hepatomegaly 1 61.68 Quite High
Fatty Liver 1 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike LDL cholesterol, measurement of non-HDL cholesterol and apo B does not require overnight fasting.
Localization (measurement) of apo B associated with disorder of lipid metabolism
1) Confidence 0.66 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2909167 Disease Relevance 1.17 Pain Relevance 0.06
Previous studies documented that serum LDL-C reduction is due to inhibition of hepatic apoB secretion, which is the main apolipoprotein in LDL particles that is recognized by the LDL receptor, and that cholesterol ester availability may be important in regulating apo B secretion.
Localization (secretion) of apoB associated with disorder of lipid metabolism
2) Confidence 0.66 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.59 Pain Relevance 0
Carr et al. [38,39] affirmed that when ACAT is highly inhibited in African green monkey, both apo B and cholesterol ester secretion are reduced, but when ACAT is moderately inhibited cholesterol ester secretion may be reduced without affecting apo B secretion.
Localization (secretion) of apo B
3) Confidence 0.66 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.63 Pain Relevance 0
Previous studies documented that serum LDL-C reduction is due to inhibition of hepatic apoB secretion, which is the main apolipoprotein in LDL particles that is recognized by the LDL receptor, and that cholesterol ester availability may be important in regulating apo B secretion.
Localization (secretion) of apo B associated with disorder of lipid metabolism
4) Confidence 0.66 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.58 Pain Relevance 0
Carr et al. [38,39] affirmed that when ACAT is highly inhibited in African green monkey, both apo B and cholesterol ester secretion are reduced, but when ACAT is moderately inhibited cholesterol ester secretion may be reduced without affecting apo B secretion.
Localization (secretion) of apo B
5) Confidence 0.66 Published 2005 Journal Lipids Health Dis Section Body Doc Link PMC1266394 Disease Relevance 0.75 Pain Relevance 0
Although the present results showing that dietary 1% pomegranate seed oil rich in 9c, 11t, 13c-CLNA could not alleviate hyperlipidemia in OLETF rats, our previous report indicated that purified 9c, 11t, 13c-CLNA suppressed the secretion of apolipoprotein B100 from human liver derived HepG2 cells [17].
Localization (secretion) of apolipoprotein B100 in liver associated with hyperlipidemia and disorder of lipid metabolism
6) Confidence 0.03 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC534798 Disease Relevance 0.80 Pain Relevance 0

General Comments

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