INT179788

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 19.96
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sparc) extracellular space (Sparc) extracellular region (Sparc)
proteinaceous extracellular matrix (Sparc) nucleus (Sparc) intracellular (Sparc)
Anatomy Link Frequency
fibroblasts 7
platelets 3
skin 3
lungs 3
decidua 2
Sparc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 25 100.00 Very High Very High Very High
fibrosis 529 99.12 Very High Very High Very High
Inflammatory marker 16 98.16 Very High Very High Very High
Inflammation 170 97.96 Very High Very High Very High
cytokine 66 97.24 Very High Very High Very High
dexamethasone 106 92.68 High High
rheumatoid arthritis 28 88.64 High High
Inflammatory response 17 85.28 High High
corticosteroid 22 81.72 Quite High
ischemia 5 80.60 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 849 100.00 Very High Very High Very High
Disease 217 100.00 Very High Very High Very High
Osteoporosis 33 100.00 Very High Very High Very High
Cancer 325 99.92 Very High Very High Very High
Apoptosis 45 99.92 Very High Very High Very High
Breast Cancer 94 99.84 Very High Very High Very High
Stomach Cancer 58 99.84 Very High Very High Very High
Acute Coronary Syndrome 265 99.16 Very High Very High Very High
Systemic Sclerosis 160 98.88 Very High Very High Very High
Coronary Artery Disease 75 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While precise mechanism of these changes is still unknown, increased expression of SPARC was reported to correlate with the levels of inflammatory markers [32,33].
Gene_expression (expression) of SPARC associated with inflammatory marker
1) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.66 Pain Relevance 0.30
After transfection of SPARC siRNA, the fibroblasts showed a decreased expression of Col1a2 that was originally over-expressed in the TBR1CA; Cre-ER mice (Figure 2).
Gene_expression (transfection) of SPARC siRNA in fibroblasts
2) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.33 Pain Relevance 0
This notion also is supported by the observation of an over-expression of SPARC in the fibroblasts of the TBR1CA; Cre-ER mice (Figure 1).
Gene_expression (expression) of SPARC in fibroblasts
3) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.22 Pain Relevance 0
Notably, increased expression of SPARC has been observed in affected skin and circulation of patients with SSc [10,11], a devastating disease of systemic fibrosis, as well as in cultured dermal fibroblasts obtained from SSc skin [8,9].
Gene_expression (expression) of SPARC in skin associated with fibrosis, disease and systemic sclerosis
4) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 1.82 Pain Relevance 0.34
These results appear to contradict our previous report of parallel inhibition of SPARC and CTGF expression in human fibroblasts by SPARC siRNA [14].
Gene_expression (expression) of SPARC in fibroblasts
5) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.38 Pain Relevance 0.09
Seventy-two hours after SPARC siRNA or Ctgf siRNA transfection, significant reductions of SPARC (95%) by SPARC siRNA and Ctgf (64%) by Ctgf siRNA were observed in the fibroblasts (Figure 2A).
Gene_expression (transfection) of SPARC siRNA in fibroblasts
6) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.07 Pain Relevance 0
Compared with parental MIP101 colorectal cancer cells, calcitriol markedly reduces cell growth and enhances calcitriol alone- or calcitriol+fluorouracil-induced apoptosis in SPARC-overexpressing MIP101 cells 64.
Gene_expression (overexpressing) of SPARC associated with colon cancer and apoptosis
7) Confidence 0.75 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.76 Pain Relevance 0.04
The possibility that SPARC may be ectopically expressed in those patients, such as in the activated platelets, cannot be excluded [37].
Gene_expression (expressed) of SPARC in platelets
8) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.79 Pain Relevance 0
siRNAs of SPARC and Ctgf reduced the collagen contents in bleomycin-induced mouse skin and lung tissues
Gene_expression (siRNAs) of SPARC in skin
9) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.51 Pain Relevance 0.14
siRNAs of SPARC and Ctgf ameliorated fibrosis in skin and reduced inflammation in lungs induced by bleomycin
Gene_expression (siRNAs) of SPARC in lungs associated with fibrosis and inflammation
10) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.43 Pain Relevance 0.14
In addition to its higher expression level in the tissues of fibrotic diseases, SPARC has shown a capacity to stimulate the transforming growth factor beta (TGF-?)
Gene_expression (expression) of SPARC associated with fibrosis and disease
11) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 1.79 Pain Relevance 0.34
Also SPARC showed a nearly constant, up-regulated expression level with its maximum on day 21 of differentiation.
Gene_expression (expression) of SPARC
12) Confidence 0.65 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.26 Pain Relevance 0
Recent studies have shown that local production of SPARC is essential for maintenance of the integrity of cardiac ECM after MI, emphasizing the potential therapeutic application of this protein to prevent cardiac dilatation and dysfunction after MI [35].
Gene_expression (production) of SPARC associated with myocardial infarction
13) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.66 Pain Relevance 0.03
SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases.
Gene_expression (expressed) of SPARC in extracellular matrix associated with fibrosis and disease
14) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888211 Disease Relevance 0.49 Pain Relevance 0.07
In addition to collagen gene expression, the Ctgf and the SPARC expression were significantly or marginal significantly reduced by SPARC siRNA and Ctgf siRNA treatment, respectively (Figure 5B).
Gene_expression (expression) of SPARC
15) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.18 Pain Relevance 0.03
Similarly, Ctgf siRNA also reduced SPARC expression in skin and lungs (2.9-fold and 1.5-fold reduction with P = 0.044 and 0.102, respectively).


Gene_expression (expression) of SPARC in skin
16) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.32 Pain Relevance 0.12
Gene and protein expression of Col1a2, Ctgf and SPARC in the fibroblasts from TBR1CA; Cre-ER mice with and without transfection of siRNAs of SPARC or Ctgf
Gene_expression (expression) of SPARC in fibroblasts
17) Confidence 0.60 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0 Pain Relevance 0
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (expression) of SPARC in osteoblast associated with osteoporosis
18) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.55 Pain Relevance 0
Interestingly, the levels of platelet-secreted glycoprotein SPARC were decreased in platelets from NSTE-ACS patients as compared to stable controls, which is consistent with a platelet secretion associated to platelet activation in NSTE-ACS.
Gene_expression (levels) of SPARC in platelets associated with acute coronary syndrome
19) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.68 Pain Relevance 0
In the proteomic analysis, SPARC was detected in one spot down-regulated in platelets from NSTE-ACS patients.
Gene_expression (detected) of SPARC in platelets associated with acute coronary syndrome
20) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.25 Pain Relevance 0

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