INT179792

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.21
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nid1) cell adhesion (Nid1) proteinaceous extracellular matrix (Nid1)
extracellular matrix organization (Nid1)
Anatomy Link Frequency
basement membrane 2
stromal cells 1
uterus 1
Nid1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 48 78.80 Quite High
metalloproteinase 80 5.00 Very Low Very Low Very Low
ketamine 16 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 8 71.68 Quite High
Cancer 8 71.32 Quite High
Apoptosis 8 68.16 Quite High
Adhesions 8 49.20 Quite Low
Reprotox - General 3 8 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Hemorrhage 8 5.00 Very Low Very Low Very Low
Leukemia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study has now shown much earlier nidogen-1 protein expression in the decidual cells, glandular epithelial cells and epithelial basement membrane of the artificially induced deciduoma, and indicated aberrant increased expression of the NID1 gene during defective decidualization.
Gene_expression (expression) of NID1 gene in basement membrane
1) Confidence 0.56 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.04
This study has now shown much earlier nidogen-1 protein expression in the decidual cells, glandular epithelial cells and epithelial basement membrane of the artificially induced deciduoma, and indicated aberrant increased expression of the NID1 gene during defective decidualization.
Gene_expression (expression) of nidogen-1 protein in basement membrane
2) Confidence 0.56 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.03
Decidual cells are known to express nidogen-1 as part of the pericellular basement-membrane laid down during decidualization [39].
Gene_expression (express) of nidogen-1
3) Confidence 0.56 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.14 Pain Relevance 0
To confirm differential expression of collagen III, biglycan, SPARC and nidogen-1 at the protein level, immunohistochemistry was carried out on transverse sections of IL11Ra+/+ and IL11Ra-/- uterus collected at 48 h of decidualization, using specific antibodies (n = 5 mice per genotype, n = 3 sections per mouse).
Gene_expression (expression) of nidogen-1 in uterus
4) Confidence 0.44 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
To confirm the altered mRNA expression of the ECM genes COL3A1, SPARC, BGN and NID1 at 48 h of decidualization, quantitative real-time RT-PCR was carried out using the same RNA samples used in the microarray analysis, plus two additional RNA samples of each genotype, collected in the same way.
Gene_expression (expression) of NID1
5) Confidence 0.44 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Each of the ECM molecules investigated further in this study, collagen III, biglycan, nidogen-1 and SPARC, showed protein expression patterns consistent with a role in decidualization, with immunostaining in endometrial stromal cells and their surrounding matrices.
Gene_expression (expression) of nidogen-1 in stromal cells
6) Confidence 0.44 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.07 Pain Relevance 0
When only the samples used in the microarray analysis were considered, the difference in NID1 abundance between IL11Ra+/+ (1.13 +/- 0.12 fg/?
Gene_expression (abundance) of NID1
7) Confidence 0.42 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Following normalization, levels of RNA for COL3A1, BGN, SPARC and NID1 in IL11Ra-/- compared to wild type were statistically analysed using the paired t-test function of GraphPad Prism 3.0 (GraphPad Software, San Diego, CA).
Gene_expression (levels) of NID1
8) Confidence 0.19 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0

General Comments

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