INT17980

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Context Info
Confidence 0.58
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.52
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egln3) cytoplasm (Egln3)
Egln3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1 73.52 Quite High
isoflurane 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 88 99.84 Very High Very High Very High
Disease Progression 8 97.40 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 108 94.72 High High
Hyperoxia 220 89.48 High High
Retinal Neovascularization 4 75.80 Quite High
Cancer 4 70.44 Quite High
Sprains And Strains 148 48.04 Quite Low
Retinopathy 36 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 32 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the early time points of P15 (rat) and P13 (mouse), an increase in Egln3 of 2.5- and 3.5-fold, respectively, was observed.
Positive_regulation (increase) of Egln3
1) Confidence 0.58 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 1.54 Pain Relevance 0
PHD2 and, in particular, PHD3 were found to be greatly increased by hypoxia.
Positive_regulation (increased) of PHD3 associated with hypoxia
2) Confidence 0.45 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2821581 Disease Relevance 0.98 Pain Relevance 0
EE treatment also caused an increase in diazepam C3 hydroxylase consistent with an effect to induce P450 IIIA activity but this was found only in microsomes from birth gonadectomized female animals.
Positive_regulation (increase) of C3 hydroxylase
3) Confidence 0.06 Published 1991 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 1958510 Disease Relevance 0 Pain Relevance 0.07

General Comments

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