INT179810

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 18.28
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
ECM 5
lung 5
macrophage 1
neurite 1
structural cells 1
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 479 99.80 Very High Very High Very High
fibrosis 140 99.74 Very High Very High Very High
depression 208 98.24 Very High Very High Very High
antidepressant 4 95.84 Very High Very High Very High
fluoxetine 6 95.24 Very High Very High Very High
Inflammation 946 94.80 High High
Central nervous system 29 93.60 High High
rheumatoid arthritis 39 93.32 High High
Inflammatory response 71 92.48 High High
Arthritis 11 89.12 High High
Disease Link Frequency Relevance Heat
Fibrosis 159 99.80 Very High Very High Very High
Metastasis 33 99.80 Very High Very High Very High
Edema 10 99.80 Very High Very High Very High
Hypoxia 12 99.44 Very High Very High Very High
Nicotine Addiction 188 99.40 Very High Very High Very High
Breast Cancer 37 99.40 Very High Very High Very High
Pulmonary Disease 1156 99.28 Very High Very High Very High
Adhesions 71 99.16 Very High Very High Very High
Pathologic Processes 16 99.04 Very High Very High Very High
Stress 94 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAI-1 plays an important role in the process of peripheral tissue remodeling and fibrinolysis through inhibition of plasmin-dependent ECM degradation [67].
Protein_catabolism (degradation) of ECM
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.53 Pain Relevance 0.09
Extracellular matrix (ECM) degradation is needed for neurite outgrowth and the remodeling of crossing axonal fibers [18].
Protein_catabolism (degradation) of ECM in neurite
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.06 Pain Relevance 0
Plasmin degrades the ECM, directly by removing glycoproteins from the ECM [43] and it releases axonal guidance molecules from the extracellular matrix [19]. tPA has multifaceted effects on tissue; it interacts with parenchymal cells through proteolytic plasminogen or non-plasminogen pathways [44]–[47].
Protein_catabolism (degrades) of ECM in extracellular matrix
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.05 Pain Relevance 0
Our data in cultured VSMCs show that statins upregulate the profibrotic mediator CTGF, the inhibitor of ECM degradation PAI-1, and collagen production, all of them regulated by Smads [7], [29], [30].
Protein_catabolism (degradation) of ECM
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.51 Pain Relevance 0.03
, via Smad pathway, regulates ECM-related proteins, including the profibrotic mediator CTGF [4], [26], the inhibitor of ECM degradation, PAI-1, [27], and the main ECM component Type I Collagen (Col-1) [4].
Protein_catabolism (degradation) of ECM
5) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0 Pain Relevance 0
While not directly supporting a role in ECM degradation, these interactions suggest that IL-11 is involved in regulating the balance between MMP and TIMP activity in the tissue.


Protein_catabolism (degradation) of ECM associated with metalloproteinase
6) Confidence 0.08 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.33
Possible mechanisms by which PAI-1 promotes breast cancer include prevention of excess ECM degradation, modulation of cell adhesion, a role in angiogenesis, and the stimulation of cell proliferation [3].
Protein_catabolism (degradation) of ECM associated with breast cancer and adhesions
7) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 1.42 Pain Relevance 0.03
Consistent with these results, it has been demonstrated that insulin augments MMP-9 in human monocytes in vitro [50] and that degradation of extracellular matrix (ECM) components by MMP-9 represents a key step during macrophage tissue invasion [51].
Protein_catabolism (degradation) of ECM in monocytes associated with metalloproteinase
8) Confidence 0.07 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.92 Pain Relevance 0.38
Hence, these insights indicate that MMPs have a much more complex function in fibrosis than merely ECM degradation.
Protein_catabolism (degradation) of ECM associated with fibrosis and metalloproteinase
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.02 Pain Relevance 0.47
Additionally, uPA-uPAR binding results in the expression of cathepsin B [21], another important protease involved in ECM degradation, and significantly higher levels of cathepsin B has been found in high-grade glioblastomas [22], [23].
Protein_catabolism (degradation) of ECM associated with glioblastoma
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.88 Pain Relevance 0.06
Therefore, both the space of Disse and portal-central vein spaces, are considered to be interstitial spaces of the liver acinus, with the functional ability to synthesize and to degrade the ECM [12,15].
Protein_catabolism (degrade) of ECM in central vein
11) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.35 Pain Relevance 0.03
Thus the high levels of HA in COPD subjects would be a consequence of degradation of ECM, which in turn can bind to lung elastic fibers, thereby adaptively preventing their further degradation by protease (Cantor et al 1997, 2000).
Protein_catabolism (degradation) of ECM in lung associated with pulmonary disease
12) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.86 Pain Relevance 0.12
Also, increased hepatic lipid peroxidation, a high oxidative stress marker [66], can occur with increased membrane permeability, increased degradation of components of the ECM and edema [70].
Protein_catabolism (degradation) of ECM associated with stress and edema
13) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.78 Pain Relevance 0.10
Urokinase-type PA (uPA), which is secreted in inactive form (pro-uPA), plays a key role in ECM degradation.
Protein_catabolism (degradation) of ECM in ECM
14) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.86 Pain Relevance 0
Increased proteolytic load due to MMP-9 has been attributed to increased neutrophil recruitment in the lungs that triggers degradation of ECM and basement membrane in the airways and lungs.
Protein_catabolism (degradation) of ECM in basement membrane associated with metalloproteinase
15) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.65 Pain Relevance 0.36
Given that MD affects both deprived-eye and open-eye responses, it is critical to determine whether ECM degradation and increased spine motility relate to the depression or potentiation of visual responses.
Protein_catabolism (degradation) of ECM in eye associated with depression
16) Confidence 0.03 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.34 Pain Relevance 0.19
Together, these findings suggest that degradation of the extracellular matrix (ECM) by the tPA/plasmin cascade is an essential component of OD plasticity, possibly due to its role in promoting dendritic spine dynamics.
Protein_catabolism (degradation) of ECM in spine
17) Confidence 0.03 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.40 Pain Relevance 0.29
Degradation of chondroitin sulphate proteoglycans in the ECM can restore a rapid OD shift in adult rats (Pizzorusso et al. 2002), as can oral administration of the antidepressant fluoxetine (Maya Vetencourt et al. 2008).
Protein_catabolism (Degradation) of ECM associated with antidepressant and fluoxetine
18) Confidence 0.03 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.05 Pain Relevance 0.20
MMP-9 has an ECM degrading activity, thus suggesting the role of oxidative components of cigarette smoke in increased elastolytic enzyme activity (Russell et al 2002).
Protein_catabolism (degrading) of ECM associated with metalloproteinase
19) Confidence 0.03 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.80 Pain Relevance 0.35
By cleavage of ECM components, proteases regulate endothelial cell migration and the selective release and modulation of pro- and anti-angiogenic factors [1].
Protein_catabolism (cleavage) of ECM in endothelial cell
20) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.27 Pain Relevance 0.07

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