INT179816

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.36
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) signal transduction (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1)
plasma membrane (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
plasma 1
Pdpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 6 93.64 High High
adenocard 8 93.04 High High
cytokine 6 85.60 High High
metalloproteinase 10 65.12 Quite High
Kinase C 76 42.64 Quite Low
cva 1 23.72 Low Low
potassium channel 152 21.72 Low Low
action potential duration 8 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 1 87.60 High High
Starvation 6 75.96 Quite High
Leukemia 1 66.28 Quite High
Parkinson's Disease 241 65.28 Quite High
Reprotox - General 3 1 38.40 Quite Low
Hemorrhage 1 23.72 Low Low
Cancer 5 18.32 Low Low
Apoptosis 38 14.88 Low Low
Dna Damage 1 5.20 Low Low
Cv Unclassified Under Development 136 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The resulting phosphatidylinositol 3,4-bisphosphate then activates phosphoinositide-dependent kinase 1 (PDK1) that in turn phosphorylates and activates Akt.
Positive_regulation (activates) of phosphoinositide-dependent kinase 1
1) Confidence 0.31 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.07 Pain Relevance 0.09
The resulting phosphatidylinositol 3,4-bisphosphate then activates phosphoinositide-dependent kinase 1 (PDK1) that in turn phosphorylates and activates Akt.
Positive_regulation (activates) of PDK1
2) Confidence 0.31 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.07 Pain Relevance 0.09
Activated PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the plasma membrane, which increases the membrane recruitment of Akt/PKB and its activator PDK1, leading to the activation of Akt.
Positive_regulation (activator) of PDK1 in plasma
3) Confidence 0.15 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.16 Pain Relevance 0
IL-11 signaling can also control the initiation of translation via sequential activation of PI3-K, Pdk-1/Akt, p70 S6 kinase and ribosomal protein S6 [17].
Positive_regulation (activation) of Pdk-1
4) Confidence 0.13 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

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