INT179826

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 11.50
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il11) extracellular region (Il11) cytoplasm (Il11)
Anatomy Link Frequency
decidua 3
stromal cells 2
ciliary 1
bowel 1
parathyroid 1
Il11 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 489 99.98 Very High Very High Very High
chemokine 15 99.36 Very High Very High Very High
Arthritis 62 98.96 Very High Very High Very High
rheumatoid arthritis 202 98.88 Very High Very High Very High
Inflammation 273 97.12 Very High Very High Very High
antagonist 15 95.68 Very High Very High Very High
Inflammatory response 59 87.16 High High
visual analogue scale 24 76.96 Quite High
Pain 38 75.88 Quite High
metalloproteinase 106 61.68 Quite High
Disease Link Frequency Relevance Heat
Leukemia 33 99.92 Very High Very High Very High
Disease 155 99.48 Very High Very High Very High
Osteolysis 1 99.44 Very High Very High Very High
Reprotox - General 3 20 99.40 Very High Very High Very High
Arthritis 68 98.96 Very High Very High Very High
Rheumatoid Arthritis 206 98.88 Very High Very High Very High
Cancer 817 98.12 Very High Very High Very High
Inflammatory Bowel Disease 30 97.40 Very High Very High Very High
INFLAMMATION 334 97.12 Very High Very High Very High
Shock 1 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical expression of IL-11R?
Gene_expression (expression) of IL-11
1) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Since we have shown that PROK1 increases the expression and secretion of IL-11 we subsequently investigated whether PROK1 altered the expression levels of the receptors for IL-11¬ónamely IL-11R?
Gene_expression (expression) of IL-11
2) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
PROK1 does not alter the expression of IL-11R?
Gene_expression (expression) of IL-11
3) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.05 Pain Relevance 0
and GP130; hence we investigated the potential for autocrine or paracrine signalling by localizing the sites of protein expression of GP130, IL-11R?
Gene_expression (expression) of IL-11
4) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
Treatment of PROKR1 Ishikawa cells with 40 nM PROK1 had no effect on expression levels of IL-11R?
Gene_expression (expression) of IL-11
5) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0
Further studies using the IL-11R?
Gene_expression (using) of IL-11
6) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0.04
Sections were washed, re-blocked in NDS and incubated overnight with a goat anti-IL-11R?
Gene_expression (washed) of IL-11
7) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Treatment of first trimester decidua with 40 nM PROK1 had no effect on expression levels of IL-11R?
Gene_expression (expression) of IL-11 in decidua
8) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
Female mice with a null mutation in IL-11R?
Gene_expression (mutation) of IL-11
9) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0.04
For the IL-11R?
Gene_expression (For) of IL-11
10) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
For the IL-11R?
Gene_expression (For) of IL-11
11) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Localization of the site of expression of IL-11R?
Gene_expression (expression) of IL-11
12) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
IL11 expression correlates with development of intestinal-type gastric adenocarinoma in humans, and IL11R?
Gene_expression (expression) of IL11
13) Confidence 0.65 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.07 Pain Relevance 0.06
Immunohistochemistry showed that both IL-11R?
Gene_expression (showed) of IL-11
14) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
IL11 expression correlates with development of intestinal-type gastric adenocarinoma in humans, and IL11R?
Gene_expression (expression) of IL11
15) Confidence 0.45 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.05 Pain Relevance 0.06
Since IL11 is expressed in epithelial and stromal cells, and its gene is transcriptionally activated by Stat3 [32], it remains to be established whether IL11 may also provide an autocrine and paracrine feed forward mechanism that, akin to IL6, fuels Stat3-dependent progression of tumours other than those of the stomach.


Gene_expression (expressed) of IL11 in stomach associated with cancer
16) Confidence 0.45 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.03 Pain Relevance 0.07
IL-6 family cytokines consist of IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CP-1).
Gene_expression (consist) of IL-11 in ciliary associated with leukemia and cytokine
17) Confidence 0.43 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.21 Pain Relevance 0.74
In this study, IL-6 and IL-11 levels decreased by treatment, but the level of LIF did not.
Gene_expression (levels) of IL-11
18) Confidence 0.43 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.79 Pain Relevance 0.55
Levels of immunoreactive IL-11 are highest during the secretory phase of the cycle, when the endometrium is receptive to implantation, and IL-11 is produced by the decidualized stromal cells.
Gene_expression (Levels) of IL-11 in stromal cells
19) Confidence 0.39 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.12 Pain Relevance 0.10
Maximal expression of IL-11 and IL-11R?
Gene_expression (expression) of IL-11
20) Confidence 0.39 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.11

General Comments

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