INT179826

Context Info Confidence 0.75 First Reported 2004 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 29 Total Number 32 Disease Relevance 11.50 Pain Relevance 3.75

extracellular space (Il11) extracellular region (Il11) cytoplasm (Il11)

Anatomy Link Frequency decidua 3 stromal cells 2 ciliary 1 bowel 1 parathyroid 1 Il11 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 489 99.98 chemokine 15 99.36 Arthritis 62 98.96 rheumatoid arthritis 202 98.88 Inflammation 273 97.12 antagonist 15 95.68 Inflammatory response 59 87.16 visual analogue scale 24 76.96 Pain 38 75.88 metalloproteinase 106 61.68

Disease Link Frequency Relevance Heat Leukemia 33 99.92 Disease 155 99.48 Osteolysis 1 99.44 Reprotox - General 3 20 99.40 Arthritis 68 98.96 Rheumatoid Arthritis 206 98.88 Cancer 817 98.12 Inflammatory Bowel Disease 30 97.40 INFLAMMATION 334 97.12 Shock 1 96.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunohistochemical expression of IL-11R?

Gene_expression (expression) of IL-11

1) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0

Since we have shown that PROK1 increases the expression and secretion of IL-11 we subsequently investigated whether PROK1 altered the expression levels of the receptors for IL-11—namely IL-11R?

Gene_expression (expression) of IL-11

2) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0

PROK1 does not alter the expression of IL-11R?

Gene_expression (expression) of IL-11

3) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.05 Pain Relevance 0

and GP130; hence we investigated the potential for autocrine or paracrine signalling by localizing the sites of protein expression of GP130, IL-11R?

Gene_expression (expression) of IL-11

4) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05

Treatment of PROKR1 Ishikawa cells with 40 nM PROK1 had no effect on expression levels of IL-11R?

Gene_expression (expression) of IL-11

5) Confidence 0.75 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0

Further studies using the IL-11R?

Gene_expression (using) of IL-11

6) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0.04

Sections were washed, re-blocked in NDS and incubated overnight with a goat anti-IL-11R?

Gene_expression (washed) of IL-11

7) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0

Treatment of first trimester decidua with 40 nM PROK1 had no effect on expression levels of IL-11R?

Gene_expression (expression) of IL-11 in decidua

8) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0

Female mice with a null mutation in IL-11R?

Gene_expression (mutation) of IL-11

9) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0.04

For the IL-11R?

Gene_expression (For) of IL-11

10) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0

For the IL-11R?

Gene_expression (For) of IL-11

11) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0

Localization of the site of expression of IL-11R?

Gene_expression (expression) of IL-11

12) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0

IL11 expression correlates with development of intestinal-type gastric adenocarinoma in humans, and IL11R?

Gene_expression (expression) of IL11

13) Confidence 0.65 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.07 Pain Relevance 0.06

Immunohistochemistry showed that both IL-11R?

Gene_expression (showed) of IL-11

14) Confidence 0.65 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05

IL11 expression correlates with development of intestinal-type gastric adenocarinoma in humans, and IL11R?

Gene_expression (expression) of IL11

15) Confidence 0.45 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.05 Pain Relevance 0.06

Since IL11 is expressed in epithelial and stromal cells, and its gene is transcriptionally activated by Stat3 [32], it remains to be established whether IL11 may also provide an autocrine and paracrine feed forward mechanism that, akin to IL6, fuels Stat3-dependent progression of tumours other than those of the stomach.

Gene_expression (expressed) of IL11 in stomach associated with cancer

16) Confidence 0.45 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.03 Pain Relevance 0.07

IL-6 family cytokines consist of IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CP-1).

Gene_expression (consist) of IL-11 in ciliary associated with leukemia and cytokine

17) Confidence 0.43 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.21 Pain Relevance 0.74

In this study, IL-6 and IL-11 levels decreased by treatment, but the level of LIF did not.

Gene_expression (levels) of IL-11

18) Confidence 0.43 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.79 Pain Relevance 0.55

Levels of immunoreactive IL-11 are highest during the secretory phase of the cycle, when the endometrium is receptive to implantation, and IL-11 is produced by the decidualized stromal cells.

Gene_expression (Levels) of IL-11 in stromal cells

19) Confidence 0.39 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.12 Pain Relevance 0.10

Maximal expression of IL-11 and IL-11R?

Gene_expression (expression) of IL-11

20) Confidence 0.39 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.11

General Comments

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