INT179872

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.69
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) mitosis (HGF)
extracellular space (HGF) extracellular region (HGF) cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 5
hepatocyte 2
HGF (Homo sapiens)
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 80.48 Quite High
antagonist 1 62.16 Quite High
peptic ulcer disease 3 27.24 Quite Low
Bile 8 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 95 99.04 Very High Very High Very High
Cholangiocarcinoma 74 98.20 Very High Very High Very High
Stomach Cancer 53 95.24 Very High Very High Very High
Carcinoma 8 94.60 High High
Apoptosis 28 91.80 High High
Malignant Neoplastic Disease 9 88.40 High High
Gastritis 15 87.20 High High
Hepatocellular Cancer 73 84.72 Quite High
Adenocarcinoma 10 79.76 Quite High
Liver Cancer 5 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of HGF to c-MET triggers tyrosine autophosphorylation of the intracellular domain in the c-MET receptor and induces responses that account for mitogenesis and growth.
HGF Binding (Binding) of c-MET in HGF
1) Confidence 0.09 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.23 Pain Relevance 0
Antagonizing the binding of HGF to HGFR also inhibited invasion in HuCC-T1, a human CC cell line, in vitro and in vivo [46] suggesting that blockade of HGFR might be a therapeutic strategy which should be the focus of further studies.
HGF Binding (binding) of HGFR in HGF associated with cholangiocarcinoma
2) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.13 Pain Relevance 0.03
HGF, the ligand of c-MET, induces mRNA levels of beta-catenin and TGF-alpha, both involved in cellular growth.
HGF Binding (ligand) of c-MET in HGF
3) Confidence 0.07 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.30 Pain Relevance 0.04
Recent reports described that some factors associated with mitosis, cell movement, proliferative activity, and tumor progression such as Ki-67, hepatocyte growth factor (HGF) and its receptor, c-Met, vascular endothelial growth factor (VEGF) and its isoform VEGF-C, were found to be highly expressed in AFP-producing gastric cancer and might contribute to the poor prognosis and drug resistance of this tumor [4,16,17].
HGF Binding (receptor) of c-Met in HGF associated with cancer and stomach cancer
4) Confidence 0.06 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1939849 Disease Relevance 1.59 Pain Relevance 0
The hepatocyte growth factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide range of tissues, including epithelial cells, on binding to the receptor tyrosine kinase c-Met.
HGF Binding (binding) of c-Met in hepatocyte
5) Confidence 0.00 Published 2008 Journal BMC Syst Biol Section Abstract Doc Link PMC2254585 Disease Relevance 0.48 Pain Relevance 0
Binding of the natural ligand HGF to c-Met stimulates mitogenesis, motogenesis, and morphogenesis in epithelial cells [7].
HGF Binding (Binding) of c-Met in HGF
6) Confidence 0.00 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.49 Pain Relevance 0
The hepatocyte growth factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide range of tissues, including epithelial cells, on binding to the receptor tyrosine kinase c-Met.
hepatocyte growth factor Binding (binding) of c-Met in hepatocyte
7) Confidence 0.00 Published 2008 Journal BMC Syst Biol Section Abstract Doc Link PMC2254585 Disease Relevance 0.48 Pain Relevance 0

General Comments

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