INT179884

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 16.57
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SOCS3) aging (SOCS3) cytoplasm (SOCS3)
Anatomy Link Frequency
satellite cell 2
eosinophil 2
plasma 1
T24 1
Th2 cells 1
SOCS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 153 100.00 Very High Very High Very High
Inflammation 175 98.20 Very High Very High Very High
Inflammatory response 11 78.40 Quite High
ischemia 2 73.20 Quite High
metalloproteinase 125 72.60 Quite High
withdrawal 8 61.48 Quite High
adenocard 18 49.44 Quite Low
agonist 32 8.60 Low Low
Opioid 36 5.00 Very Low Very Low Very Low
antagonist 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 703 99.80 Very High Very High Very High
Infection 395 99.74 Very High Very High Very High
Opiate Addiction 474 99.36 Very High Very High Very High
Hepatocellular Cancer 42 98.40 Very High Very High Very High
INFLAMMATION 188 98.20 Very High Very High Very High
Epstein-barr Virus 45 97.04 Very High Very High Very High
Nasopharynx Cancer 145 93.76 High High
Asthma 319 93.56 High High
Apoptosis 27 92.52 High High
Targeted Disruption 24 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the timing of peak SOCS3 expression coincides with the peak in satellite cell number and the down-regulation of cyclin D1 expression.
Gene_expression (expression) of SOCS3 in satellite cell
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
The expression of SOCS3 positively correlated with the increase in IL-6+ SC, such that the subjects with the highest number of IL-6+ satellite cells had the highest expression of SOCS3 mRNA (Fig. 5c).
Gene_expression (expression) of SOCS3 in satellite cells
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0.06
The expression of SOCS3 and the absence of other components of the IL-6/STAT3 signaling network beyond T24 illustrate the role of this network in promoting SC proliferation.
Gene_expression (expression) of SOCS3 in T24
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.14 Pain Relevance 0
Increased expression of their downstream targets (c-Myc, bcl-xL, IL-6, LIF, SOCS-1, SOCS-3, VEGF and COX-2) was also observed.
Gene_expression (expression) of SOCS-3
4) Confidence 0.36 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.98 Pain Relevance 0
Suppressor of cytokine signaling 3 is the main isoform of that family of regulatory factors expressed in neutrophils and functions by inhibiting JAK2 kinase activity [54]–[57].
Gene_expression (expressed) of cytokine signaling 3 in neutrophils associated with cytokine
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.96 Pain Relevance 0.48
SOCS-3 is predominantly expressed in Th2 cells and inhibits Th1 differentiation [154].
Gene_expression (expressed) of SOCS-3 in Th2 cells
6) Confidence 0.28 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.49 Pain Relevance 0.07
Among the suppressor family members examined, the level of SOCS-3 gene expression was elevated in CD56+ T cells isolated from the heroin users with or without HCV infection (Fig. 7).
Gene_expression (expression) of SOCS-3 in T cells associated with hepatitis c virus infection, opiate addiction and infection
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.44 Pain Relevance 0
by CD56+ T cells and the levels of HCV RNA in plasma, or between the levels of SOCS-3/PIAS-3 in CD56+ T cells and the levels of HCV RNA in plasma was performed using Spearman's rank test (Prism 4.0 software).
Gene_expression (levels) of SOCS-3 in plasma associated with hepatitis c virus infection
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 0.38 Pain Relevance 0
In addition, the gene expressions in cHCC of SOCS3 and collagen-I were elevated (although not significantly) and inhibited, respectively, as it was also detected in human HCC [19].
Gene_expression (expressions) of SOCS3 associated with hepatocellular cancer
9) Confidence 0.19 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.59 Pain Relevance 0
In addition, there was no significant difference in the expression of SOCS-3 and PIAS-3 between the heroin users without HCV infection and the heroin users with HCV infection (Fig. 7).
Gene_expression (expression) of SOCS-3 associated with hepatitis c virus infection, opiate addiction and infection
10) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.96 Pain Relevance 0.04
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Gene_expression (expression) of cytokine signaling protein-3 associated with hepatitis c virus infection, opiate addiction, infection and cytokine
11) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 2.12 Pain Relevance 0.05
There was no association between the levels of SOCS-3 and HCV viral loads (Fig. 8).
Gene_expression (levels) of SOCS-3 associated with hepatitis c virus infection
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.87 Pain Relevance 0.03
Investigation of the mechanisms showed that although heroin use or heroin use plus HCV infection had little impact on the expression of the key positive regulators (IL-12 receptors, STAT-1, 3, 4, 5, JAK-2, and TYK-2) in IL-12 pathway, heroin use or heroin use plus HCV infection induced the expression of suppressor of cytokine signaling protein-3 (SOCS-3) and protein inhibitors of activated STAT-3 (PIAS-3), two key inhibitors of IL-12 pathway.


Gene_expression (expression) of SOCS-3 associated with hepatitis c virus infection, opiate addiction, infection and cytokine
13) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2834757 Disease Relevance 2.13 Pain Relevance 0.05
And Ecklonia cava extracts reveal Suppressor of cytokine signaling-3 (SOCS-3) expression and a reduction in the increased eosinophil peroxidase (EPO) activities.
Gene_expression (expression) of SOCS-3 in eosinophil associated with cytokine
14) Confidence 0.14 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.25 Pain Relevance 0.18
And Ecklonia cava extracts reveal Suppressor of cytokine signaling-3 (SOCS-3) expression and a reduction in the increased eosinophil peroxidase (EPO) activities.
Gene_expression (expression) of signaling-3 in eosinophil associated with cytokine
15) Confidence 0.12 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.25 Pain Relevance 0.18

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