INT179887

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 13.06
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SOCS3) aging (SOCS3) cytoplasm (SOCS3)
Anatomy Link Frequency
T cells 2
skeletal muscle 1
lung 1
T24 1
SOCS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 98.94 Very High Very High Very High
Inflammatory response 3 98.52 Very High Very High Very High
Inflammation 43 91.76 High High
Opioid 30 36.72 Quite Low
drug abuse 15 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
opiate 5 5.00 Very Low Very Low Very Low
opioid receptor 5 5.00 Very Low Very Low Very Low
Morphine 5 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 322 99.72 Very High Very High Very High
Hepatitis C Virus Infection 588 99.52 Very High Very High Very High
Insulin Resistance 12 99.44 Very High Very High Very High
Opiate Addiction 395 99.34 Very High Very High Very High
INFLAMMATION 52 98.52 Very High Very High Very High
Hepatocellular Cancer 54 97.94 Very High Very High Very High
Obesity 115 92.80 High High
Viral Infection 10 91.44 High High
Hepatitis 15 90.32 High High
Pressure And Volume Under Development 6 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent research has demonstrated that the activation of SOCS3 in the lung occurs during the acute inflammatory response [46].
Positive_regulation (activation) of SOCS3 in lung associated with inflammatory response
1) Confidence 0.50 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.68 Pain Relevance 0.16
Phosphorylated STAT3 was evident in SCs 4 h after lengthening contraction, and the downstream genes, cyclin D1 and SOCS3 were significantly elevated 24 hours after the intervention.


Positive_regulation (elevated) of SOCS3
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0.03
We observed p-STAT3 within the SCs at T4, with the downstream genes cyclin D1 and SOCS3 increasing from T4-T24, suggesting that the IL-6/STAT3 signaling pathway was active within SCs early, during early proliferation, prior to the expansion of the SC population.
Positive_regulation (increasing) of SOCS3 in T24
3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.13 Pain Relevance 0.03
From two novel proteins associated with hepatocellular carcinomas in man [5], suppressors of cytokine signaling type 3 (SOCS3) and collagen-I, a non-significant 2-fold elevation of SOCS3, were found and a 7-fold, significant down-regulation of collagen-I was observed.
Positive_regulation (elevation) of SOCS3 associated with hepatocellular cancer and cytokine
4) Confidence 0.36 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.49 Pain Relevance 0.05
In vitro studies demonstrated that chronic exposure to IL-6 induces insulin resistance in skeletal muscle through induction of JNK, SOCS-3, and protein tyrosine phosphatase 1B [36].
Positive_regulation (induction) of SOCS-3 in skeletal muscle associated with insulin resistance
5) Confidence 0.21 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.68 Pain Relevance 0.08
SOCS-3 has been reported to be a negative regulator of IL-12 signaling by preventing STAT-4 binding to the IL-12R?
Positive_regulation (reported) of SOCS-3
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.33 Pain Relevance 0
Taken together, the findings presented in this study provide compelling ex vivo as well as in vivo evidence that heroin use or heroin use plus HCV infection, through the induction of two key suppressors (SOCS-3 and PIAS-3) in IL-12 pathway, suppressed IFN-?
Positive_regulation (induction) of SOCS-3 associated with hepatitis c virus infection, opiate addiction and infection
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.75 Pain Relevance 0
Among the suppressor members [suppressors of cytokine signaling (SOCS)-1, 2, and 3, protein inhibitors of activated STAT (PIAS)-1, 3, x, and y] tested, SOCS-3 levels, were elevated in CD56+ T cells freshly isolated from the heroin users with or without HCV infection (Fig. 7).
Positive_regulation (elevated) of SOCS-3 in T cells associated with hepatitis c virus infection, opiate addiction, infection and cytokine
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.63 Pain Relevance 0.05
Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users

Background

Positive_regulation (Upregulation) of SOCS-3 associated with opiate addiction and hepatitis c virus infection
9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Title Doc Link PMC2834757 Disease Relevance 1.57 Pain Relevance 0
Among the suppressor members [suppressors of cytokine signaling (SOCS)-1, 2, and 3, protein inhibitors of activated STAT (PIAS)-1, 3, x, and y] tested, SOCS-3 levels, were elevated in CD56+ T cells freshly isolated from the heroin users with or without HCV infection (Fig. 7).
Positive_regulation (activated) of SOCS-3 in T cells associated with hepatitis c virus infection, opiate addiction, infection and cytokine
10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.75 Pain Relevance 0.05

General Comments

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