INT179889

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.71
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1B) endosome (CDKN1B) nucleoplasm (CDKN1B)
nucleus (CDKN1B) cell cycle (CDKN1B) kinase activity (CDKN1B)
CDKN1B (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 12 91.36 High High
antagonist 4 86.64 High High
Inflammation 12 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 62 99.60 Very High Very High Very High
Apoptosis 62 95.80 Very High Very High Very High
Cancer 171 89.36 High High
Cirrhosis 20 86.16 High High
Obesity 1 83.40 Quite High
Breast Cancer 125 74.68 Quite High
Polyploidy 1 63.08 Quite High
Colon Cancer 52 53.64 Quite High
Liver Cancer 2 52.40 Quite High
Aging 5 51.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other essential regulators of the cell cycle are the cyclin-dependent kinase (CDK) inhibitors, such as p21Cip1 and p27Kip1, which have inhibitory effects on several CDKs [26,27].
Negative_regulation (inhibitors) of p27Kip1
1) Confidence 0.57 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
Both p27kip and PTEN are inhibited in human HCC as well [17,18].
Negative_regulation (inhibited) of p27kip associated with hepatocellular cancer
2) Confidence 0.42 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.64 Pain Relevance 0
This anticancer activity is due to inhibition of cell proliferation, by interfering with important cell cycle cyclins and cyclin-dependent kinase inhibitors, such as p27kip1, but also by a proapoptotic action.
Negative_regulation (inhibitors) of p27kip1
3) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.45 Pain Relevance 0.21
The association of cyclin D1 to Cdk is crucial to drive cells to the restriction point where the cell is committed to divide.129,130 D-type cyclins bind to Cdks 4 and 6 and phosphorylate downstream substrates, mainly pRb, and these complexes can also sequester Cdk inhibitors (p21Cip1 and p27 Kip1) in the G1/S transition115,129,130 (Fig. 1).
Negative_regulation (inhibitors) of p27 Kip1
4) Confidence 0.26 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.37 Pain Relevance 0
The cell cycle is regulated by cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors, such as p21Cip1 and p27Kip1associated proteins [24,25].
Negative_regulation (inhibitors) of p27Kip1
5) Confidence 0.18 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.25 Pain Relevance 0

General Comments

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