INT179905

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELANE, SRI) signal transduction (SRI) transport (SRI)
peptidase activity (ELANE) extracellular region (ELANE) plasma membrane (SRI)
Anatomy Link Frequency
neutrophil 2
ELANE (Homo sapiens)
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neutrophil Disorders 22 100.00 Very High Very High Very High
Neutropenia 3 96.24 Very High Very High Very High
Disease 3 82.00 Quite High
Agranulocytosis 17 77.00 Quite High
Toxicity 2 50.00 Quite Low
Leukemia 2 14.16 Low Low
Lymphatic System Cancer 7 9.04 Low Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 3 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In theory, SCN and CN are caused by an accumulation of neutrophil elastase, leading to an inactivation of G-CSF and a negative feedback on granulopoiesis, which causes neutropenia.
Positive_regulation (accumulation) of elastase in neutrophil Positive_regulation (caused) of SCN associated with neutropenia and neutrophil disorders
1) Confidence 0.19 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.92 Pain Relevance 0

General Comments

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