INT179917

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
epithelium 2
lung 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 18 98.12 Very High Very High Very High
ischemia 4 91.52 High High
isoflurane 1 79.92 Quite High
anesthesia 3 79.04 Quite High
metalloproteinase 29 70.40 Quite High
Inflammatory mediators 10 58.16 Quite High
cytokine 12 47.60 Quite Low
Inflammatory response 1 37.08 Quite Low
Arthritis 1 31.12 Quite Low
Buprenorphine 1 24.80 Low Low
Disease Link Frequency Relevance Heat
Injury 10 98.34 Very High Very High Very High
Pneumonia 5 98.12 Very High Very High Very High
Sepsis 20 97.16 Very High Very High Very High
Cv Unclassified Under Development 3 91.52 High High
Lung Injury 13 89.52 High High
Adult Respiratory Distress Syndrome 31 78.48 Quite High
INFLAMMATION 27 58.16 Quite High
Stress 2 47.92 Quite Low
Hypoxia 2 34.92 Quite Low
Arthritis 1 31.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we identified a mechanism through which sepsis produces epithelial barrier dysfunction by demonstrating that altered expression of key tight junction proteins in our septic epithelium are reversed with ERK MAPk inhibition.


Negative_regulation (reversed) of Negative_regulation (inhibition) of ERK in epithelium associated with sepsis
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.38 Pain Relevance 0.12
To explore a new therapeutic strategy for preventing the occurrence of LPS-induced lung inflammation and injury, we attempted to inhibit JNK or ERK activity by pretreatment with a selective JNK inhibitor, SP600125, or a specific inhibitor of MEK/ERK, PD98059, 1 hour before LPS treatment.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of ERK in lung associated with inflammation, injury and pneumonia
2) Confidence 0.17 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.79 Pain Relevance 0.16

General Comments

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