INT179928

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ephb1, Mapk8) cytoplasm (Ephb1, Mapk8) cytosol (Mapk8)
endosome (Ephb1) mitochondrion (Mapk8) nucleus (Mapk8)
Anatomy Link Frequency
lung 1
Ephb1 (Rattus norvegicus)
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 29 92.64 High High
Inflammation 13 83.96 Quite High
Inflammatory mediators 7 80.40 Quite High
ischemia 3 79.24 Quite High
Arthritis 1 53.36 Quite High
cytokine 6 35.32 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 17 99.28 Very High Very High Very High
Lung Injury 13 97.80 Very High Very High Very High
Injury 6 84.40 Quite High
Pneumonia 3 83.96 Quite High
INFLAMMATION 18 80.40 Quite High
Cv Unclassified Under Development 2 79.24 Quite High
Arthritis 1 53.36 Quite High
Hyperoxia 2 36.00 Quite Low
Stress 2 35.64 Quite Low
Ulcers 2 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of either JNK or ERK activity resulted in reduction of LPS-induced increases in lung injury parameters, as well as neutrophil influx into the lungs, indicating that aggravating signals related to both JNK and ERK are associated with LPS-induced acute lung injury.
ERK Binding (associated) of JNK in lung associated with lung injury and adult respiratory distress syndrome
1) Confidence 0.11 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.91 Pain Relevance 0.26

General Comments

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