INT17993

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 7.34
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RASA1) signal transduction (RASA1) plasma membrane (RASA1)
embryo development (RASA1) cytoplasm (RASA1)
RASA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
neuralgia 4 99.86 Very High Very High Very High
medulla 1 98.96 Very High Very High Very High
Pain 8 98.92 Very High Very High Very High
gABA 3 98.84 Very High Very High Very High
Trigeminal neuralgia 10 96.96 Very High Very High Very High
GABAergic 1 88.64 High High
Inflammation 20 86.56 High High
Migraine 2 83.72 Quite High
Hippocampus 2 82.72 Quite High
headache 4 80.24 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 48 100.00 Very High Very High Very High
Periodontitis 25 100.00 Very High Very High Very High
Arterial-venous Cerebral Malformations 24 100.00 Very High Very High Very High
Neuralgia 12 99.86 Very High Very High Very High
Convulsion 6 99.44 Very High Very High Very High
Pain 8 98.92 Very High Very High Very High
Hemorrhage 7 98.12 Very High Very High Very High
Ganglion Cysts 4 95.60 Very High Very High Very High
INFLAMMATION 23 86.56 High High
Facial Neuralgia 2 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gap junction conductance has also been shown to be decreased by gamma-aminobutyric acid (GABA)ergic input.
Negative_regulation (decreased) of Gap associated with gaba
1) Confidence 0.41 Published 2000 Journal Novartis Found. Symp. Section Abstract Doc Link 10965507 Disease Relevance 0 Pain Relevance 0.41
Some forms of seizure activity can be stopped by gap junctional (GJ) blockade.
Negative_regulation (blockade) of gap associated with convulsion
2) Confidence 0.41 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 19840216 Disease Relevance 0.33 Pain Relevance 0.06
Removal of AVM is important not only for pain relief but also for protecting bleeding.
Negative_regulation (Removal) of AVM associated with pain, hemorrhage and arterial-venous cerebral malformations
3) Confidence 0.38 Published 1984 Journal No To Shinkei Section Abstract Doc Link 6335663 Disease Relevance 2.09 Pain Relevance 0.88
The patient was completely relieved from the neuralgia after removal of the AVM.
Negative_regulation (removal) of AVM associated with neuralgia and arterial-venous cerebral malformations
4) Confidence 0.38 Published 1984 Journal No To Shinkei Section Abstract Doc Link 6335663 Disease Relevance 2.14 Pain Relevance 0.89
The AVM was eliminated in 19 of 20 patients (nine with preoperative partial embolization) treated with surgery versus in 4 of 27 patients treated only with embolization.
Negative_regulation (eliminated) of AVM
5) Confidence 0.34 Published 1996 Journal Neurology Section Body Doc Link 8780071 Disease Relevance 0.20 Pain Relevance 0
Both patients presented here had surgical results seemingly antithetical to a relationship: the attacks persisted in the first patient and began in the second after removal of the AVM.
Negative_regulation (removal) of AVM associated with arterial-venous cerebral malformations
6) Confidence 0.33 Published 1991 Journal Headache Section Abstract Doc Link 1960053 Disease Relevance 0.99 Pain Relevance 0.24
Complete removal of the AVM was documented by postoperative angiography in every case.
Negative_regulation (removal) of AVM
7) Confidence 0.33 Published 2000 Journal J. Neurosurg. Section Body Doc Link 10616080 Disease Relevance 0 Pain Relevance 0
Although we aimed to evaluate the reduction of apoptosis in the GAP group, we could not demonstrate any significant difference between the positive staining cells of caspase-3 in both groups.
Negative_regulation (reduction) of GAP associated with periodontitis and apoptosis
8) Confidence 0.05 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 1.60 Pain Relevance 0.14

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