INT17997

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Context Info
Confidence 0.49
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 12.71
Pain Relevance 6.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscles 2
poly 1
chest 1
epithelium 1
Mch (Mus musculus)
Pain Link Frequency Relevance Heat
headache 49 100.00 Very High Very High Very High
Migraine 18 100.00 Very High Very High Very High
c fibre 3 98.32 Very High Very High Very High
dexamethasone 10 97.08 Very High Very High Very High
Pain 17 92.08 High High
Inflammation 294 91.04 High High
agonist 27 90.72 High High
Inflammatory response 13 89.20 High High
referred pain 2 88.48 High High
qutenza 3 69.36 Quite High
Disease Link Frequency Relevance Heat
Headache 45 100.00 Very High Very High Very High
Migraine Without Aura 12 100.00 Very High Very High Very High
Cough 9 99.98 Very High Very High Very High
Hypersensitivity 117 99.84 Very High Very High Very High
Respiratory Syncytial Virus 495 97.36 Very High Very High Very High
Infection 320 96.76 Very High Very High Very High
Toxicity 4 92.16 High High
Pain 10 92.08 High High
Stress 2 91.32 High High
Pulmonary Disease 9 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, airway responses to Mch were increased after milk aspiration when compared with control mice.
Positive_regulation (increased) of Mch
1) Confidence 0.49 Published 2000 Journal Pediatr. Res. Section Abstract Doc Link 11102546 Disease Relevance 0.47 Pain Relevance 0.13
Tenderness of pericranial muscles was present in all headache patients with severity increasing in the order CM, MCH, CM + MCH; it was absent in all the controls.
Positive_regulation (increasing) of MCH in muscles associated with migraine and headache
2) Confidence 0.40 Published 1982 Journal Pain Section Abstract Doc Link 7048208 Disease Relevance 1.91 Pain Relevance 1.89
Tenderness of pericranial muscles was present in all headache patients with severity increasing in the order CM, MCH, CM + MCH; it was absent in all the controls.
Positive_regulation (increasing) of MCH in muscles associated with migraine and headache
3) Confidence 0.40 Published 1982 Journal Pain Section Abstract Doc Link 7048208 Disease Relevance 1.91 Pain Relevance 1.90
A single OVA aerosol was sufficient to induce a significant increase in MCh responsiveness in the airways, seen as both a lower threshold dose of MCh required to induce a response (increased sensitivity) and increased response at the 24 hour time point (Table 1).
Positive_regulation (increase) of MCh
4) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0
Sensitisation followed by challenge with a single PBS aerosol did not cause an increase in sensitivity or maximum responsiveness to MCh compared to naïve mice.
Positive_regulation (increase) of MCh
5) Confidence 0.39 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0
Usually the response is expressed as fold increase of Penh for each MCh concentration compared with Penh values after an initial buffer challenge with the aerosolized vehicle.
Positive_regulation (increase) of MCh
6) Confidence 0.38 Published 2007 Journal Respir Res Section Body Doc Link PMC2039738 Disease Relevance 0 Pain Relevance 0
These results suggest that epithelial barrier function remained intact in these animals; however the level of permeability of the epithelium in these mice simply may not have been great enough to allow extravasation of the large Evans Blue dye-albumin complex whilst being sufficient to allow greater access of MCh (~300 × smaller than albumin) to the ASM.
Positive_regulation (access) of MCh in epithelium
7) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.42 Pain Relevance 0.03
Responsiveness to MCh
Positive_regulation (Responsiveness) of MCh
8) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 1.04 Pain Relevance 0.10
Similarly, we did not observe increased responsiveness to MCh in tracheal segments from adult or weanling mice at 7 d (Figure 8).
Positive_regulation (increased) of MCh
9) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.42 Pain Relevance 0.05
The aim of the present study was to investigate the relation between bronchoconstriction and cough induced by methacholine (Mch) inhalation and to elucidate the role of C-fibers and rapidly adapting irritant receptors (RARs) in these reactions in conscious guinea pigs.
Spec (investigate) Positive_regulation (induced) of Mch associated with c fibre and cough
10) Confidence 0.37 Published 2009 Journal Exp. Lung Res. Section Abstract Doc Link 19415547 Disease Relevance 0.31 Pain Relevance 0.17
Increasing doses of MCh were administered by constant infusion (3 – 96 ?
Positive_regulation (Increasing) of MCh
11) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.54 Pain Relevance 0.04
Coyle et al (JCI 1995) demonstrated that the cationic proteins major basic protein and poly-L-lysine increased immunoreactive kinins and kallikrein-like activity in vivo and that this mechanism explained the epithelial-dependant increase in MCh responsiveness.
Positive_regulation (increase) of MCh in poly
12) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.89 Pain Relevance 0.06
We studied the performance of these tests at baseline and following increasing aerosolized MCh challenges as well as in the context of a therapeutic intervention with dexamethasone, a drug known to inhibit allergen-induced airway hyperresponsiveness.
Positive_regulation (increasing) of MCh associated with dexamethasone
13) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2904286 Disease Relevance 0 Pain Relevance 0.05
In February 1993 the patient (MCH) initiated a collaboration with the first author (WJB, Faculty of Medicine, University of Arizona), for a study designed to evaluate and document any changes in signs and symptoms (e.g. respiratory function, chest wall morphology and excursion, Cobb angle).
Positive_regulation (initiated) of MCH in chest
14) Confidence 0.33 Published 2009 Journal Scoliosis Section Body Doc Link PMC2808297 Disease Relevance 0.33 Pain Relevance 0.17
Chronic OVA challenge in WT mice induced a statistically significant increase in airway responsiveness to Mch (WT OVA vs WT no OVA, Mch 48 mg/ml)(p < 0.002)(Figure 8B).
Positive_regulation (increase) of Mch
15) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.13 Pain Relevance 0.03
Nevertheless, despite this variability, it is important to emphasize that the noninvasive measurement of EF50 still reflected the enhanced AR to A. fumigatus and MCh in allergic relative to control mice (Figs. 1, 3).
Positive_regulation (enhanced) of MCh associated with hypersensitivity
16) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.45 Pain Relevance 0.05
To further characterize the utility of noninvasive vs. noninvasive pulmonary function tests, AR to increasing doses of aerosolized MCh, was investigated 48 h after EAR recordings in the same animals.
Positive_regulation (increasing) of MCh
17) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.28 Pain Relevance 0
Newtonian airway resistance, a measure of central airway resistance, was significantly increased in the vehicle animals at both 25 and 50 mg/ml Mch as compared to PBS challenged animals.
Positive_regulation (increased) of Mch
18) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.58 Pain Relevance 0.13
The increases of PF4 in MCH and migraine during this test were significantly greater than in healthy controls.
Positive_regulation (increases) of MCH associated with migraine and headache
19) Confidence 0.26 Published 1989 Journal Cephalalgia Section Abstract Doc Link 2706677 Disease Relevance 1.02 Pain Relevance 1.05
After 4-8 weeks on high 'sub-toxic' doses of HU all patients responded with a multifold increase of fetal haemoglobin (HbF) and a marked increase of MCV and MCH; they also felt significantly better and ceased having pains or other complaints.
Positive_regulation (increase) of MCH
20) Confidence 0.14 Published 1995 Journal Br. J. Haematol. Section Abstract Doc Link 7537527 Disease Relevance 0.61 Pain Relevance 0.17

General Comments

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