INT18001

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 21
Total Number 26
Disease Relevance 7.63
Pain Relevance 11.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr2c) nucleus (Htr2c) cytoplasm (Htr2c)
signal transducer activity (Htr2c)
Anatomy Link Frequency
choroid plexus 2
neuronal 1
medial region 1
neurons 1
5-HT neurons 1
Htr2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 94 100.00 Very High Very High Very High
Migraine 13 99.84 Very High Very High Very High
sSRI 96 99.76 Very High Very High Very High
fluoxetine 54 99.76 Very High Very High Very High
antidepressant 6 99.46 Very High Very High Very High
gABA 21 99.00 Very High Very High Very High
Morphine 9 98.72 Very High Very High Very High
Nucleus accumbens 26 98.68 Very High Very High Very High
agonist 43 98.52 Very High Very High Very High
Dopamine 44 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine Disorders 10 99.84 Very High Very High Very High
Anxiety Disorder 669 99.76 Very High Very High Very High
Panic Disorder 4 99.68 Very High Very High Very High
Injury 4 98.64 Very High Very High Very High
Cognitive Disorder 6 98.52 Very High Very High Very High
Headache 20 98.16 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.68 Very High Very High Very High
Premature Ejaculation 318 94.88 High High
Psychosis 4 85.52 High High
Urological Neuroanatomy 11 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that 5-HT via activation of 5-HT1A, 5-HT2A, 5-HT2C and possibly also 5-HT1B receptors increases the synthesis of CRH in the PVN and POMC in the anterior pituitary lobe, which results in increased ACTH secretion.
Spec (possibly) Positive_regulation (activation) of 5-HT2C in lobe
1) Confidence 0.67 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.31
These results suggest that the activation of 5-HT2C receptors selectively inhibits morphine-induced DA release in the NAc in a manner which is independent of the inhibition of 5-HT neurons.
Positive_regulation (activation) of 5-HT2C in 5-HT neurons associated with nucleus accumbens, dopamine and morphine
2) Confidence 0.67 Published 1998 Journal Brain Res. Section Abstract Doc Link 9507167 Disease Relevance 0 Pain Relevance 1.75
In addition to effects via 5-HT1A receptors, activation of 5-HT2A and 5-HT2C receptor subtypes might be involved in excitatory effects and inhibitory effects of 5-HT respectively.
Positive_regulation (activation) of 5-HT2C
3) Confidence 0.67 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9446695 Disease Relevance 0 Pain Relevance 0.24
CONCLUSIONS: Taken together, the results indicate that the anxiogenic-like effect as well as the facilitated neuronal reactivity induced by acute fluoxetine in the airjet model is mediated primarily by activation of 5-HT2C receptors.


Positive_regulation (activation) of 5-HT2C in neuronal
4) Confidence 0.67 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 16521035 Disease Relevance 0 Pain Relevance 0
The central mechanism of the reported effects might involve stimulation of 5-HT2C receptors by fluoxetine in animals with PTZ-induced decrease in the threshold for emotional arousal.
Spec (might) Positive_regulation (stimulation) of 5-HT2C associated with anxiety disorder and fluoxetine
5) Confidence 0.67 Published 2006 Journal Pharmacol Rep Section Abstract Doc Link 16531638 Disease Relevance 0.31 Pain Relevance 0.70
In conclusion, the results show that chronic citalopram and fluoxetine treatments induce an increase of choroid plexus 5-HT2C receptor density, but the effect is more marked with citalopram.
Positive_regulation (increase) of 5-HT2C in choroid plexus associated with fluoxetine
6) Confidence 0.67 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8840350 Disease Relevance 0 Pain Relevance 0.76
Chronic citalopram and fluoxetine treatments upregulate 5-HT2c receptors in the rat choroid plexus.
Positive_regulation (upregulate) of 5-HT2c in choroid plexus associated with fluoxetine
7) Confidence 0.67 Published 1996 Journal Neuropsychopharmacology Section Title Doc Link 8840350 Disease Relevance 0 Pain Relevance 0.55
It has been suggested that activation of 5-HT2C receptors is involved in the initiation of a migraine attack.
Positive_regulation (activation) of 5-HT2C associated with migraine
8) Confidence 0.67 Published 1994 Journal Life Sci. Section Abstract Doc Link 8107508 Disease Relevance 0.31 Pain Relevance 0.32
Furthermore, the certain magnitude of ICP increases was likely to have occurred despite the stimulus intensity after the level of 5-HT2C receptor activation crossed the threshold.


Positive_regulation (activation) of 5-HT2C
9) Confidence 0.67 Published 2006 Journal J. Urol. Section Body Doc Link 16600805 Disease Relevance 0 Pain Relevance 0
These results suggest that increased anxiety in rodents, and possibly, also in humans (e.g. agitation or jitteriness after SSRIs and panic after m-CPP), caused by acute administration of SSRI antidepressants or m-CPP, are mediated by activation of 5-HT2C receptors.
Positive_regulation (activation) of 5-HT2C associated with antidepressant, anxiety disorder and ssri
10) Confidence 0.67 Published 2001 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 11806866 Disease Relevance 0.40 Pain Relevance 0.76
Hypothesis: serotonin-1C receptor activation in migraine: an alternative point of view with therapeutic implication.
Positive_regulation (activation) of serotonin-1C receptor associated with migraine and serotonin
11) Confidence 0.49 Published 1991 Journal Headache Section Title Doc Link 1960061 Disease Relevance 0.56 Pain Relevance 0.75
Under this hypothesis, specific serotonin-1C receptor activation is not a necessary condition for the genesis of the migraine attack.
Positive_regulation (activation) of serotonin-1C receptor associated with migraine and serotonin
12) Confidence 0.49 Published 1991 Journal Headache Section Abstract Doc Link 1960061 Disease Relevance 0.62 Pain Relevance 0.77
These findings suggest that operant ethanol self-administration can be suppressed in a specific manner by activation of 5-HT2A and, possibly, 5-HT2C receptors, and in a nonselective manner by activation of 5-HT1B receptors.
Spec (possibly) Positive_regulation (activation) of 5-HT2C
13) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10334495 Disease Relevance 0 Pain Relevance 0.39
Some researchers have found that the activation of the 5-HT2C receptor induces self-grooming in rats.52 This result supports the hypothesis that selective stimulation of central 5-HT2C receptors exacerbates symptoms in OCD.
Positive_regulation (activation) of 5-HT2C associated with anxiety disorder
14) Confidence 0.49 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.91 Pain Relevance 0
Treatment with an SSRI class drug activates the 5-HT2C receptor, elevates the ejaculatory threshold set-point and delays ejaculation.
Positive_regulation (activates) of 5-HT2C associated with ssri
15) Confidence 0.49 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671940 Disease Relevance 0.88 Pain Relevance 0.09
In our previous study, the 5HT2A receptor mRNA was significantly reduced, whereas the 5HT2C receptor mRNA was enhanced after repeated intermittent MDMA administration [25], indicating on compensatory mechanisms in response to long term MDMA administration.
Positive_regulation (enhanced) of 5HT2C
16) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.25 Pain Relevance 0.49
It has also been reported that m-CPP, which stimulates 5-HT2C receptor, exacerbates OC symptoms.30,31 Theses studies provide support for the possible involvement of 5-HT2C receptors in the etiology of OCD.
Positive_regulation (stimulates) of 5-HT2C associated with anxiety disorder
17) Confidence 0.49 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.97 Pain Relevance 0
Chronic citalopram treatment caused a consistent and dose-related increase in the density of 5-HT2C receptors (up to 90%).
Positive_regulation (increase) of 5-HT2C
18) Confidence 0.49 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8840350 Disease Relevance 0 Pain Relevance 0.37
The second is likely to arise from axon collaterals of SNr neurons themselves and is facilitated by an increase in firing via postsynaptic, somatodendritic 5-HT2C receptor activation, but it is depressed by GABA(B) receptor activation.
Positive_regulation (activation) of 5-HT2C in neurons associated with gaba
19) Confidence 0.49 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8922413 Disease Relevance 0.06 Pain Relevance 0.78
In contrast, the prominent increases in 5-HT2A/2C binding after severe 5-HT deprivation as restricted to the medial region of the striatum and suggest up-regulation of most probably 5-HT2C receptors in a region implicated in cognitive functions.
Positive_regulation (up-regulation) of 5-HT2C in medial region associated with cognitive disorder
20) Confidence 0.49 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630549 Disease Relevance 0.10 Pain Relevance 0.35

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