INT180027

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.06
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tgm2) mitochondrion (Tgm2) proteinaceous extracellular matrix (Tgm2)
plasma membrane (Tgm2) transferase activity, transferring acyl groups (Tgm2) cytoplasm (Tgm2)
Tgm2 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 4 86.24 High High
medulla 6 60.00 Quite High
Inflammation 9 33.92 Quite Low
cva 2 27.44 Quite Low
cINOD 3 16.00 Low Low
aspirin 4 8.40 Low Low
imagery 16 7.12 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
intrathecal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 31 99.32 Very High Very High Very High
Celiac Disease 126 98.76 Very High Very High Very High
Cancer 306 98.56 Very High Very High Very High
Apoptosis 51 98.28 Very High Very High Very High
Anaphylaxis 27 97.72 Very High Very High Very High
Malignant Neoplastic Disease 20 87.68 High High
Cv Unclassified Under Development 3 86.24 High High
Death 25 85.56 High High
Ataxia 66 83.56 Quite High
Necrosis 30 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Palosuo and colleagues showed that tTG cross-links wheat gliadins in individuals with wheat-dependent EIA, causing the formation of high-molecular-weight complexes with enhanced IgE binding capability [18].
tTG Binding (-) of associated with anaphylaxis
1) Confidence 0.35 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873610 Disease Relevance 0.42 Pain Relevance 0.08
Class1 anti-TG2 recognizes both human and rodent TG2 [8], [26], [32] while the class2 scFv recognizes human but not guinea pig [8], [20], [26] or mouse TG2 [33].
TG2 Binding (recognizes) of
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.29 Pain Relevance 0
These class1 and class2 anti-TG2 scFvs appear to be representative of two distinct patterns of Ig reactivity with TG2 typically seen, i.e. recognize distinct epitopes of TG2 that are commonly targeted in CD [8], [26]. scFvs belonging to class1 and the well characterized anti-TG2 monoclonal antibody CUB7402 recognize human, mouse and guinea pigTG2 whereas class2 scFv reacts only with human-TG2 (Figure S2) [8].
TG2 Binding (recognize) of associated with celiac disease
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.35 Pain Relevance 0.03
Class1 anti-TG2 recognizes both human and rodent TG2 [8], [26], [32] while the class2 scFv recognizes human but not guinea pig [8], [20], [26] or mouse TG2 [33].
TG2 Binding (recognizes) of
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.28 Pain Relevance 0
As cell membrane integrity is lost during the late phase of apoptosis, cytoplasmic La becomes accessible to binding by specific mAb, which in turn becomes crosslinked in the dying cell by TG2 so that its levels are higher than in dead cells of the counterpart primary cell type [29].
TG2 Binding (crosslinked) of associated with apoptosis
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.14 Pain Relevance 0
Significant differences between the survival rates of the mice treated with different amounts of electrical charge (P < 0.05) were also found, being more marked for TG1-3 and TG2-3 for Ehrlich and fibrosarcoma Sa-37 tumors, respectively.
TG2-3 Binding (marked) of associated with fibrosarcoma and cancer
6) Confidence 0.19 Published 2004 Journal BMC Cancer Section Body Doc Link PMC539271 Disease Relevance 1.58 Pain Relevance 0

General Comments

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