INT18007

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 14.98
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)
Anatomy Link Frequency
myocardium 2
B cells 2
capsule 1
thyroid 1
lung 1
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 5 99.68 Very High Very High Very High
Trigeminal neuralgia 6 99.60 Very High Very High Very High
carbamazepine 8 98.82 Very High Very High Very High
rheumatoid arthritis 124 96.76 Very High Very High Very High
imagery 14 96.48 Very High Very High Very High
Pain 63 93.52 High High
cytokine 69 91.44 High High
Inflammation 87 88.72 High High
headache 28 82.48 Quite High
Dopamine 12 77.12 Quite High
Disease Link Frequency Relevance Heat
Agammaglobulinemia 11 100.00 Very High Very High Very High
Infection 205 99.64 Very High Very High Very High
Headache 29 99.60 Very High Very High Very High
Rupture 3 99.42 Very High Very High Very High
Disease 178 99.34 Very High Very High Very High
Coronary Heart Disease 272 99.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 117 99.00 Very High Very High Very High
Bacterial Meningitis 81 97.84 Very High Very High Very High
Primary Sclerosing Cholangitis 71 97.60 Very High Very High Very High
Autoimmune Disease 37 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liquor cells and total protein were significantly increased; however, a hemagglutination inhibition test revealed only moderately increased immunoglobulin values.
Positive_regulation (increased) of immunoglobulin
1) Confidence 0.66 Published 1996 Journal Ger J Ophthalmol Section Abstract Doc Link 8646173 Disease Relevance 0.53 Pain Relevance 0.27
Patients with anti-IgA antibodies, intolerant of low-IgA IVIg have successfully been transitioned to subcutaneous therapy.20,29 Young children and pregnant women with PIDD have safely received subcutaneous infusions of immunoglobulin.30,31 And while little data exists on the use of subcutaneous immunoglobulin therapy in patients with significant thrombocytopenia, anticoagulant use or bleeding disorders, there is a report of the safe use of subcutaneous therapy in a child with CVID and von Willebrand disease.32

Comparative costs of immunoglobulin therapy

Positive_regulation (infusions) of immunoglobulin associated with coagulation disorder, thrombocytopenia and disease
2) Confidence 0.35 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.74 Pain Relevance 0
We have treated patients with carbamazepine resistant primary trigeminal neuralgia (rpTN) using human pooled intravenous immunoglobulin (IVIG) in a prospective multiple-dose, open-label cohort study [5].
Positive_regulation (pooled) of intravenous immunoglobulin associated with trigeminal neuralgia and carbamazepine
3) Confidence 0.24 Published 2003 Journal BMC Neurol Section Body Doc Link PMC149450 Disease Relevance 0.89 Pain Relevance 0.53
The study design assumed that a threefold increase in serum levels of capsule-specific immunoglobulin level would be measured in response to vaccine in all subjects, and that the range of values obtained would be similar to those in earlier studies [10].
Positive_regulation (increase) of immunoglobulin in capsule
4) Confidence 0.20 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0.16 Pain Relevance 0.03
The studies do agree that inhaled 23-PPV is less effective than injected but in our series we did not see the increase in serum immunoglobulin levels in response to inhaled vaccine seen in some subjects (4/10 in healthy subjects, 7/10 in COPD patients) previous studies.
Positive_regulation (increase) of immunoglobulin associated with pulmonary disease
5) Confidence 0.18 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0.10 Pain Relevance 0
The first novel finding from this study is that subcutaneous 23-PPV results in increased immunoglobulin levels in BAL. 23-PPV is protective against invasive pneumococcal disease [34] but does not protect adults against pneumonia [17], and has been shown to cause an excess of pneumonia in some studies [15].
Positive_regulation (increased) of immunoglobulin associated with bacterial meningitis and pneumonia
6) Confidence 0.14 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0.79 Pain Relevance 0
Further, we also showed that although conjugate vaccination resulted in increased pneumococcal capsule-specific immunoglobulin in lung fluid from both HIV infected and immunocompetent adults [24], the immunoglobulin function was impaired in HIV infected subjects [25].
Positive_regulation (increased) of immunoglobulin in lung associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.14 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 1.08 Pain Relevance 0.04
We have addressed the hypothesis that vaccination may differ from native disease in that vaccination may fail to induce adequate levels of protective pulmonary mucosal immunoglobulin.
Neg (fail) Positive_regulation (induce) of immunoglobulin associated with disease
8) Confidence 0.12 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 1.31 Pain Relevance 0.04
After discontinuation of PHT and VPA, steroid and immunoglobulin treatment was required for 4 weeks before his condition improved.
Positive_regulation (required) of immunoglobulin
9) Confidence 0.05 Published 1990 Journal Epilepsia Section Abstract Doc Link 2111770 Disease Relevance 0.92 Pain Relevance 0.11
Patients developed moderate increases of serum levels of soluble interleukin-2 receptors, beta 2-microglobin, and immunoglobulin M (IgM), and of the acute phase reactants, C-reactive protein (CRP), fibrinogen, and haptoglobin.
Positive_regulation (increases) of immunoglobulin M
10) Confidence 0.05 Published 1991 Journal J. Clin. Oncol. Section Abstract Doc Link 1960553 Disease Relevance 0.33 Pain Relevance 0.07
Normal values were found for cortisol, prolactin, testosterone, follicle-stimulating hormone, luteinizing hormone, alpha-subunit, and thyroid-stimulating immunoglobulin.
Positive_regulation (thyroid-stimulating) of immunoglobulin in thyroid
11) Confidence 0.03 Published 2003 Journal South. Med. J. Section Abstract Doc Link 14513996 Disease Relevance 0.73 Pain Relevance 0.12
Immunoglobulin and eotaxin receptors were also found to be upregulated.
Positive_regulation (upregulated) of Immunoglobulin
12) Confidence 0.02 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.48 Pain Relevance 0
Hypergammaglobulinaemia occurs in a third of patients and immunoglobulin M (IgM) levels are increased in 50% of patients with advanced disease.


Positive_regulation (increased) of immunoglobulin M associated with disease
13) Confidence 0.01 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1636629 Disease Relevance 1.59 Pain Relevance 0.11
We suspect that focal transmission was associated with recent DENV introductions because of the 217 paired serologic specimens from positive cluster enrollees, only one revealed an elevated but declining immunoglobulin M level, which would be indicative of a recent DENV infection occurring up to 60 d prior to cluster initiation [22].
Positive_regulation (elevated) of immunoglobulin M associated with infection
14) Confidence 0.01 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2577695 Disease Relevance 0.33 Pain Relevance 0
Herbert et al., in their experiment with mice using human parasites, showed that B cells play no part in the defense against primary infection but play an important role in subsequent challenge infections with a resultant increase in parasite specific immunoglobulin, mainly IgM [78].
Positive_regulation (increase) of immunoglobulin in B cells associated with infection
15) Confidence 0.01 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1538622 Disease Relevance 0.79 Pain Relevance 0
TRAF6 was also identified as a T cell-intrinsic negative regulator in mice with T cell-specific TRAF6 deletion, in which signs of hyperactive humoral immunity, including increased serum levels of immunoglobulin and DNA autoantibodies [37-39], were observed with similar clinical features of RA.
Positive_regulation (increased) of immunoglobulin in T cell associated with rheumatoid arthritis
16) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.39 Pain Relevance 0.17
This in turn, stimulates activated B cells to proliferate and differentiate supporting the hypothesis that PRL promotes a rupture of tolerance by stimulating increased immunoglobulin G (IgG) production [7].
Positive_regulation (increased) of immunoglobulin in B cells associated with rupture and tolerance
17) Confidence 0.01 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 1.00 Pain Relevance 0.30
Immune status is a major concern in patients treated with rituximab being the induction of low CD20+ counts and hypogammaglobulinemia (specifically low levels of immunoglobulin M), two previously reported secondary effects.
Positive_regulation (induction) of immunoglobulin M associated with agammaglobulinemia
18) Confidence 0.00 Published 2007 Journal Ann Hematol Section Body Doc Link PMC2040174 Disease Relevance 0.72 Pain Relevance 0
Smaller concentrations of nonmaternal fetal cells may aid the viability of the fetus, but higher levels may trigger autoimmune disease.50 Development of autoantibodies against smooth and cardiac muscle has also been reported.5,50 These autoantibodies may cross react with the myocardium and can cause cardiomyopathy.5,25,50,62 The higher rate of PPCM in twin pregnancies and its familial predisposition also support this autoimmune theory.32 Warraich et al. found markedly increased levels of immunoglobulin (IgG and subclasses) in PPCM patients.
Positive_regulation (support) of immunoglobulin in myocardium associated with autoimmune disease and coronary heart disease
19) Confidence 0.00 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628138 Disease Relevance 0.69 Pain Relevance 0
Smaller concentrations of nonmaternal fetal cells may aid the viability of the fetus, but higher levels may trigger autoimmune disease.50 Development of autoantibodies against smooth and cardiac muscle has also been reported.5,50 These autoantibodies may cross react with the myocardium and can cause cardiomyopathy.5,25,50,62 The higher rate of PPCM in twin pregnancies and its familial predisposition also support this autoimmune theory.32 Warraich et al. found markedly increased levels of immunoglobulin (IgG and subclasses) in PPCM patients.
Positive_regulation (increased) of immunoglobulin in myocardium associated with autoimmune disease and coronary heart disease
20) Confidence 0.00 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628138 Disease Relevance 0.68 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox