INT18009

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Context Info
Confidence 0.70
First Reported 1981
Last Reported 2011
Negated 22
Speculated 11
Reported most in Abstract
Documents 518
Total Number 529
Disease Relevance 553.03
Pain Relevance 103.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 30
erythrocyte 27
blood 20
white blood cell 14
neutrophil 9
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6557 100.00 Very High Very High Very High
cytokine 2329 100.00 Very High Very High Very High
Inflammatory marker 715 100.00 Very High Very High Very High
Angina 714 100.00 Very High Very High Very High
metalloproteinase 220 100.00 Very High Very High Very High
addiction 182 99.98 Very High Very High Very High
withdrawal 62 99.98 Very High Very High Very High
Pain 716 99.96 Very High Very High Very High
abdominal pain 106 99.92 Very High Very High Very High
rheumatoid arthritis 2369 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7871 100.00 Very High Very High Very High
Disease 3962 100.00 Very High Very High Very High
Cancer 2295 100.00 Very High Very High Very High
Stress 1199 100.00 Very High Very High Very High
Fever 824 100.00 Very High Very High Very High
Thyroiditis 594 100.00 Very High Very High Very High
Necrosis 586 100.00 Very High Very High Very High
Cv General 3 Under Development 562 100.00 Very High Very High Very High
Colon Cancer 545 100.00 Very High Very High Very High
Adhesions 417 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, adjustment for BMI (which had the most potent attenuating effect) is unlikely to represent an overadjustment, since weight gain is associated with an increase in CRP, and weight loss with a CRP reduction [49]–[51].
Positive_regulation (increase) of CRP associated with weight loss and weight gain
1) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.80 Pain Relevance 0.04
Subgroup analysis of target lesions associated with ACS according to the clinical Braunwald classification showed an increase of intimal CRP with classes I-III.
Positive_regulation (increase) of CRP associated with acute coronary syndrome
2) Confidence 0.70 Published 2002 Journal Z Kardiol Section Abstract Doc Link 12442194 Disease Relevance 1.25 Pain Relevance 0.28
All of these data are consistent with the hypothesis that CRP levels increase after onset of oral cancer.
Positive_regulation (increase) of CRP associated with mouth cancer
3) Confidence 0.70 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2921363 Disease Relevance 1.23 Pain Relevance 0.05
However, it is still unclear whether CRP levels are elevated before the biological onset of cancer or if an elevated CRP level is also a risk factor for the development of cancer.
Spec (whether) Positive_regulation (elevated) of CRP associated with cancer
4) Confidence 0.70 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2921363 Disease Relevance 1.58 Pain Relevance 0.37
The proportion of lymph node metastasis in the group of elevated CRP levels was smaller than that in the patients without CRP elevation.
Positive_regulation (elevated) of CRP in lymph node associated with metastasis
5) Confidence 0.70 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2921363 Disease Relevance 1.12 Pain Relevance 0
However, it is still unclear whether CRP levels are elevated before the biological onset of cancer or if an elevated CRP level is also a risk factor for the development of cancer.
Spec (whether) Positive_regulation (elevated) of CRP associated with cancer
6) Confidence 0.70 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2921363 Disease Relevance 1.51 Pain Relevance 0.35
Two hypotheses could be associated with increased CRP levels as a sign of chronic inflammation.
Positive_regulation (increased) of CRP associated with inflammation
7) Confidence 0.70 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2921363 Disease Relevance 2.02 Pain Relevance 0.55
Serum amyloid A (SAA) and C-reactive protein (CRP) reactants of the acute phase of inflammation, have been shown to be increased in patients with CHD.
Positive_regulation (increased) of CRP associated with coronary artery disease, inflammation and alzheimer's dementia
8) Confidence 0.70 Published 2000 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 10652189 Disease Relevance 1.33 Pain Relevance 0.28
The diagnosis of polymyalgia rheumatica (PMR) was made from the clinical symptoms, elevated C-reactive protein and erythrocyte sedimentation rate.
Positive_regulation (elevated) of C-reactive protein in erythrocyte associated with polymyalgia rheumatica
9) Confidence 0.70 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11197806 Disease Relevance 1.07 Pain Relevance 0.37
Common symptoms and laboratory findings included fever, abdominal pain, leukocytosis, and elevated C-reactive protein.
Positive_regulation (elevated) of C-reactive protein associated with abdominal pain, leukocytosis and fever
10) Confidence 0.70 Published 1997 Journal J. Gastroenterol. Section Abstract Doc Link 9349996 Disease Relevance 1.27 Pain Relevance 0.10
Blood chemistry showed elevated liver enzymes, elevated kidney retention parameters and an increased C-reactive protein.
Positive_regulation (increased) of C-reactive protein in kidney
11) Confidence 0.70 Published 2006 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 16817101 Disease Relevance 0.82 Pain Relevance 0.15
A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP).
Positive_regulation (elevated) of C-reactive protein associated with neuropathy, psoriasis, pain, fever and reprotox - general 1
12) Confidence 0.70 Published 2006 Journal Mod Rheumatol Section Abstract Doc Link 16906379 Disease Relevance 0.70 Pain Relevance 0.10
A 47-year-old man who had been taking minocycline for palmoplantar pustulosis developed fever, myalgias, polyneuropathy, and testicular pain, with elevated C-reactive protein (CRP).
Positive_regulation (elevated) of CRP associated with neuropathy, psoriasis, pain, fever and reprotox - general 1
13) Confidence 0.70 Published 2006 Journal Mod Rheumatol Section Abstract Doc Link 16906379 Disease Relevance 0.70 Pain Relevance 0.10
The laboratory findings revealed increased C-reactive protein (CRP) levels up to 100 mg/l, leucocytes 8.8 G/l, and serum lactate levels of 4.5 mmol/l.
Positive_regulation (increased) of CRP in leucocytes
14) Confidence 0.70 Published 2010 Journal World J Emerg Surg Section Body Doc Link PMC2824631 Disease Relevance 1.31 Pain Relevance 0.17
The laboratory findings revealed increased C-reactive protein (CRP) levels up to 100 mg/l, leucocytes 8.8 G/l, and serum lactate levels of 4.5 mmol/l.
Positive_regulation (increased) of C-reactive protein in leucocytes
15) Confidence 0.70 Published 2010 Journal World J Emerg Surg Section Body Doc Link PMC2824631 Disease Relevance 1.31 Pain Relevance 0.17
However, the above-mentioned previous reports [8, 14–16], findings of elevated serum CRP levels in SAT patients reported by Pearce et al. [11], and the demonstration of increased saliva CRP levels in SAT patients of the present study indirectly suggest the possibility of the existence of a positive correlation between saliva and serum CRP levels in the subjects.
Positive_regulation (increased) of CRP in saliva associated with thyroiditis
16) Confidence 0.69 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 0.58 Pain Relevance 0.19
His initial laboratory examination showed leukocytosis, eosinophilia, and elevated C-reactive protein.
Positive_regulation (elevated) of C-reactive protein associated with leukocytosis and eosinophilia
17) Confidence 0.69 Published 2008 Journal Am. J. Med. Sci. Section Abstract Doc Link 18552586 Disease Relevance 1.24 Pain Relevance 0.13
A 73-year-old man admitted for back pain and a low-grade fever was found in laboratory studies to have severe leukocytosis and increased C-reactive protein, but neither computed tomography (CT) nor vertebral magnetic resonance imaging (MRI) clarified the cause of infection in the painful hip lesion, and paralysis developed. in the left leg MRI eventually indicated a vertebral abscess involving multiple lesions at C4-7 and L4-5.
Positive_regulation (increased) of C-reactive protein in hip associated with pain, abscess, fever, infection, backache, leukocytosis, imagery and paralysis
18) Confidence 0.69 Published 2008 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 18411767 Disease Relevance 0.92 Pain Relevance 0.34
Leukocytosis, pyuria and elevated C-reactive protein were found.
Positive_regulation (elevated) of C-reactive protein associated with pyuria and leukocytosis
19) Confidence 0.69 Published 2007 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 17282974 Disease Relevance 0.98 Pain Relevance 0.25
A raised baseline CRP value has been associated with inflammation, endothelial dysfunction, obesity [17], the metabolic syndrome [18, 19], diabetes mellitus [20], insulin resistance [7], and severity of hypertension [21], and thus, various metabolic disorders may occur by increasing CRP level and simultaneously promote an increase in LV mass.
Positive_regulation (increasing) of CRP associated with metabolic disorder, inflammation, diabetes mellitus, hypertension, obesity, metabolic syndrome and insulin resistance
20) Confidence 0.69 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975076 Disease Relevance 1.39 Pain Relevance 0.12

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