INT180098

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.74
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Egfl7) extracellular space (Egfl7) extracellular region (Egfl7)
Anatomy Link Frequency
plaque 1
Heart 1
Egfl7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 97.82 Very High Very High Very High
cINOD 4 84.24 Quite High
cytokine 3 83.12 Quite High
ischemia 5 59.04 Quite High
Kinase C 30 58.52 Quite High
Inflammatory marker 3 58.28 Quite High
cva 2 10.64 Low Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 58 99.32 Very High Very High Very High
Disorder Of Lipid Metabolism 45 99.28 Very High Very High Very High
Calcification 93 98.78 Very High Very High Very High
Cardiovascular Disease 65 98.00 Very High Very High Very High
INFLAMMATION 41 97.82 Very High Very High Very High
Atherosclerosis 61 97.56 Very High Very High Very High
Alzheimer's Dementia 39 88.04 High High
Sudden Death 1 87.88 High High
Shock 1 85.96 High High
Coronary Artery Disease 128 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However as the cholesterol levels remained elevated compared to normal levels (±2 fold, data not shown) and as our in vitro results suggest that statin effects are not dependant on cholesterol reduction, it is reasonable to espaculate that in vivo effect atorvastatin is likely to be through an inhibition of small GTP-ases.
Neg (not) Regulation (dependant) of statin
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.55 Pain Relevance 0.08
For instance, the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) involving over 5,000 elderly patients with ischemic HF, found no significant beneficial effect of statin treatment with rosuvastatin on risk reduction of CVD events.42 Likewise, rosuvastatin treatment had a similar influence as placebo in terms of CVD outcomes in over 4,500 patients with ischemic and non-ischemic HF enrolled in the GISSI-HF trial.43
Neg (no) Regulation (effect) of statin in Heart associated with cardiovascular disease and myocardial infarction
2) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952453 Disease Relevance 1.68 Pain Relevance 0
This lack of complete clarity is emphasized by the older ARBITER-2 and the recently released NIA Plaque study.41,52 ARBITER-2 compared adding long acting niacin to statin treatment and found only a trend toward plaque regression as compared to placebo.41 NIA Plaque added niacin or placebo to patients with low HDL-C but whose LDL-C was already well controlled on statin therapy.52 In this study, there was no difference in regression of intima wall plaque from niacin or placebo.
Regulation (controlled) of statin in plaque associated with atherosclerosis and disorder of lipid metabolism
3) Confidence 0.02 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2978935 Disease Relevance 0.73 Pain Relevance 0
In order to refine our localization of the subcellular target of statin action, we evaluated the steady-state levels of cell-surface APP (csAPP) in the absence or presence of statins.
Regulation (target) of statin
4) Confidence 0.01 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
CA ROCK1 and DN ROCK1 molecules yielded direct and complementary evidence that ROCK1 was indeed a candidate for modulation of statin-activated ?
Regulation (modulation) of statin
5) Confidence 0.01 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.08 Pain Relevance 0.11
The hs-CRP is a well-known marker of inflammatory status and is a reliable prognostic factor following CABG [17-19], and has already been used as an index of targeting statin therapy for prevention of coronary events [20,21].
Regulation (targeting) of statin associated with inflammation
6) Confidence 0.01 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872864 Disease Relevance 0.69 Pain Relevance 0.11
Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK

Background

Regulation (Modulation) of Statin
7) Confidence 0.01 Published 2005 Journal PLoS Medicine Section Title Doc Link PMC543463 Disease Relevance 0.17 Pain Relevance 0.03
We found that patients treated with statins had higher levels of MGP, and since we also found a positive correlation between HDL levels and MGP and a negative correlation between LDL levels and MGP, it could be speculated that higher MGP levels were an indication of better clinical and prognostic regulation of lipid levels due to statin treatment.
Regulation (regulation) of statin associated with calcification and disorder of lipid metabolism
8) Confidence 0.01 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 1.84 Pain Relevance 0.08

General Comments

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