INT18010

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 122
Total Number 127
Disease Relevance 100.80
Pain Relevance 18.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
platelets 6
plasma 5
blood 5
B cells 4
coronary artery 3
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 629 100.00 Very High Very High Very High
Arthritis 902 99.84 Very High Very High Very High
Multiple sclerosis 152 99.40 Very High Very High Very High
Angina 94 98.96 Very High Very High Very High
anesthesia 13 98.68 Very High Very High Very High
cva 81 98.40 Very High Very High Very High
nud 4 97.98 Very High Very High Very High
rheumatoid arthritis 396 97.92 Very High Very High Very High
Regional anesthesia 3 97.64 Very High Very High Very High
Inflammation 605 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dengue 562 100.00 Very High Very High Very High
Fever 386 100.00 Very High Very High Very High
Influenza Virus Infection 109 100.00 Very High Very High Very High
Obesity 74 100.00 Very High Very High Very High
Adhesions 40 100.00 Very High Very High Very High
Cytomegalovirus Infection 13 100.00 Very High Very High Very High
Chlamydia Infection 4 100.00 Very High Very High Very High
Infection 1014 99.98 Very High Very High Very High
Neuromyelitis Optica 269 99.98 Very High Very High Very High
Thrombocytopenia 36 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The diagnosis of WM was established after cytomorphologic and immunohistochemical analysis of the patient's bone marrow revealed the presence of a lymphoid/lymphoplasmacytoid-like bone marrow infiltrate along with an elevated serum IgM level.
Spec (like) Positive_regulation (elevated) of IgM in bone marrow associated with macroglobulinemia
1) Confidence 0.70 Published 2006 Journal Am. J. Hematol. Section Abstract Doc Link 16888782 Disease Relevance 1.14 Pain Relevance 0.28
IgM elevation is interpreted as a reaction to an affection of the tracheo-bronchial system; this reaction did not occur with the CEA group.
Positive_regulation (elevation) of IgM
2) Confidence 0.66 Published 1984 Journal Anasth Intensivther Notfallmed Section Abstract Doc Link 6517243 Disease Relevance 0 Pain Relevance 0.23
Patients with a general anaesthesia had a high increase in serum IgM on the 7th day after operation, whereas there was no increase in the patients who had received CEA.
Positive_regulation (increase) of IgM
3) Confidence 0.66 Published 1984 Journal Anasth Intensivther Notfallmed Section Abstract Doc Link 6517243 Disease Relevance 0 Pain Relevance 0.24
ELISA allowed the determination of brucella-specific immunoglobulins (Ig)G, IgM and IgA in the CSF, and provided profiles of Ig, in sera, which were different in patients with chronic (elevated IgG and IgA) from those with acute (elevated IgM alone or IgG, IgM and IgA) brucellosis.
Positive_regulation (elevated) of IgM associated with brucella infection
4) Confidence 0.64 Published 1988 Journal Q. J. Med. Section Abstract Doc Link 3051080 Disease Relevance 1.26 Pain Relevance 0.14
Only the transaminases and the borrelia serology (IgG: 1:80, IgM:neg.) were slightly elevated, and the abdominal sonography revealed a moderate hepatomegaly.
Positive_regulation (elevated) of IgM associated with hepatomegaly
5) Confidence 0.58 Published 1995 Journal Klin Monbl Augenheilkd Section Abstract Doc Link 8587309 Disease Relevance 0.60 Pain Relevance 0.09
The level of soluble CD40 ligand was slightly correlated with measured levels of troponin T (r=0.21, p<0.05), and the increased soluble CD40L levels (>8.0 ng/ml) were associated with higher risk for AMI, sudden death and recurrent angina.
Positive_regulation (increased) of CD40L
6) Confidence 0.55 Published 2004 Journal Clin. Chim. Acta Section Body Doc Link 15115688 Disease Relevance 0.16 Pain Relevance 0
Of special interest to us were the increased serum levels of sCD154 in children with different JIA subtypes.
Positive_regulation (increased) of sCD154 associated with arthritis
7) Confidence 0.52 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.49 Pain Relevance 0.72
We have demonstrated that sCD154 levels are elevated in sera from children with JIA.
Positive_regulation (elevated) of sCD154 associated with arthritis
8) Confidence 0.52 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.02 Pain Relevance 0.55
In all patients elevated IgG antibody titers and in one patient also elevated IgM titer were found.
Positive_regulation (elevated) of IgM
9) Confidence 0.49 Published 1989 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 2476974 Disease Relevance 0.51 Pain Relevance 0.15
IgM ELISA tests for yellow fever virus were negative in case 1 and positive in case 2; similar tests for dengue, hantaviruses, arenaviruses, Leptospira, and hepatitis viruses A-D were negative.
Positive_regulation (negative) of IgM
10) Confidence 0.49 Published 2001 Journal Lancet Section Body Doc Link 11463409 Disease Relevance 0.11 Pain Relevance 0
However, to date, no studies have investigated the effect of metabolic syndrome on circulating soluble CD40 ligand (sCD40L), monocyte chemoattractant protein 1, cellular adhesion molecules, and disease severity in patients with symptomatic coronary artery diseases.
Spec (investigated) Positive_regulation (circulating) of CD40 ligand in coronary artery associated with coronary artery disease, metabolic syndrome, disease and adhesions
11) Confidence 0.49 Published 2006 Journal Metab. Clin. Exp. Section Abstract Doc Link 16839837 Disease Relevance 1.08 Pain Relevance 0.08
Coagulation activation and expression of CD40 ligand on platelets upon in vitro lipopolysaccharide-challenge in patients with unstable angina.
Positive_regulation (activation) of CD40 ligand in platelets associated with angina
12) Confidence 0.49 Published 2006 Journal Int. J. Cardiol. Section Title Doc Link 16182391 Disease Relevance 0.29 Pain Relevance 0.19
IMMUNOGLOBULINS: Registry data support a positive effect of 20 g i.v. pentaglobin (IgG and IgM) in adenovirus positive myocarditis for clinical improvement, eradication of both the inflammation and the virus.
Positive_regulation (effect) of IgM associated with myocarditis and inflammation
13) Confidence 0.49 Published 2004 Journal Herz Section Abstract Doc Link 15912438 Disease Relevance 0.85 Pain Relevance 0.22
The syndromes of injury after cardiac surgical procedures are diagnoses of exclusion, but the diagnosis of postperfusion syndrome ("40-day postoperative fever") may be made on the basis of elevated cytomegalovirus IgM titers.
Positive_regulation (elevated) of IgM associated with syndrome, injury, cytomegalovirus infection and fever
14) Confidence 0.49 Published 1997 Journal Heart Lung Section Abstract Doc Link 9090522 Disease Relevance 2.25 Pain Relevance 0.17
Repeated measures ANOVA revealed significant differences between the BMS and RS groups as regards the increases in plasma levels of vascular cell adhesion molecule-1 (VCAM-1, p = 0.022), plasminogen activator inhibitor-1 (PAI-1, p = 0.047), tissue-type plasminogen activator (tPA, p = 0.047) and CD40 ligand (CD40L, p = 0.038). tPA levels tended to increase immediately after stenting in both groups, whereas the PAI-1 level one month after stenting was elevated significantly only in the RS group.
Positive_regulation (increases) of CD40 ligand in plasma associated with adhesions
15) Confidence 0.49 Published 2008 Journal Thromb. Haemost. Section Abstract Doc Link 18392332 Disease Relevance 0.80 Pain Relevance 0.18
RESULTS: The concentrations of IgM autoantibodies to MnSOD of the children with neuroborreliosis were significantly increased, compared with the two control groups.
Positive_regulation (increased) of IgM
16) Confidence 0.49 Published 2005 Journal Neuropediatrics Section Body Doc Link 16429379 Disease Relevance 0.09 Pain Relevance 0
Human blood B cells highly express Cox-2 mRNA and protein and produce PGs after activation with CD40L, pansorbin, or CD40L plus BCR engagement.
Positive_regulation (activation) of CD40L in B cells
17) Confidence 0.47 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.38 Pain Relevance 0.38
Human blood B cells highly express Cox-2 mRNA and protein and produce PGs after activation with CD40L, pansorbin, or CD40L plus BCR engagement.
Positive_regulation (activation) of CD40L in B cells
18) Confidence 0.47 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.37 Pain Relevance 0.38
We hypothesized that SF is linked to increases in circulating cytokines and CD40 Ligand (CD40L).
Positive_regulation (increases) of CD40L associated with cytokine
19) Confidence 0.47 Published 2010 Journal Psychophysiology Section Abstract Doc Link 20230500 Disease Relevance 0.64 Pain Relevance 0.29
We hypothesized that SF is linked to increases in circulating cytokines and CD40 Ligand (CD40L).
Positive_regulation (increases) of CD40 Ligand associated with cytokine
20) Confidence 0.47 Published 2010 Journal Psychophysiology Section Abstract Doc Link 20230500 Disease Relevance 0.63 Pain Relevance 0.29

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