INT180100

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.00
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam10) nucleocytoplasmic transport (Adam10) Golgi apparatus (Adam10)
nucleus (Adam10) cytoplasm (Adam10)
Adam10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 33 97.48 Very High Very High Very High
Inflammation 139 96.24 Very High Very High Very High
long-term potentiation 4 87.28 High High
cINOD 137 86.80 High High
Kinase C 26 55.76 Quite High
metalloproteinase 8 53.40 Quite High
COX-2 inhibitor 3 44.48 Quite Low
glial activation 6 29.40 Quite Low
Hippocampus 13 5.00 Very Low Very Low Very Low
Inflammatory mediators 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 168 96.24 Very High Very High Very High
Targeted Disruption 66 94.88 High High
Amyloid Plaque 39 93.48 High High
Disease 198 88.88 High High
Cognitive Disorder 39 87.84 High High
Alzheimer's Dementia 52 86.80 High High
Neuroblastoma 8 77.68 Quite High
Necrosis 9 66.64 Quite High
Cancer 9 66.28 Quite High
Pathologic Processes 3 52.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase of APP, revealed activation of ADAM10 as a promising therapeutic target, and supported the hypothesis that a decrease in ?
Positive_regulation (activation) of ADAM10
1) Confidence 0.33 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.81 Pain Relevance 0.16
Overexpression of ADAM10 increases ?
Positive_regulation (increases) of ADAM10
2) Confidence 0.32 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.25 Pain Relevance 0.05
has been reported to increase ADAM-17 and ADAM-10 levels and ?
Positive_regulation (increase) of ADAM-10
3) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.47 Pain Relevance 0.27
and LPS, are able to increase ADAM10 activity, leading to a loss in E-cadherin expression, which is another substrate for this secretase [68].
Positive_regulation (increase) of ADAM10
4) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.30 Pain Relevance 0.31
These investigators proposed that elevated ADAM-10 activity and protein levels contributed to these effects.
Positive_regulation (elevated) of ADAM-10
5) Confidence 0.10 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.08 Pain Relevance 0.03
These investigators proposed that elevated ADAM-10 activity and protein levels contributed to these effects.
Positive_regulation (contributed) of ADAM-10
6) Confidence 0.07 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox