INT180104

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 15 83.56 Quite High
Hippocampus 7 57.52 Quite High
antagonist 1 52.80 Quite High
gABA 1 51.96 Quite High
long-term potentiation 5 29.12 Quite Low
cINOD 2 7.44 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 129 88.60 High High
Alzheimer's Dementia 16 83.80 Quite High
Apoptosis 134 82.80 Quite High
Cognitive Disorder 16 58.84 Quite High
Amyloidosis 3 22.00 Low Low
Targeted Disruption 6 19.28 Low Low
INFLAMMATION 14 7.20 Low Low
Death 56 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 36 5.00 Very Low Very Low Very Low
Stress 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cytoplasmic domains of both APP and ADAM-17 have been evaluated as candidates for important targets of protein phosphorylation during the regulated shedding process, but neither “substrate activation” nor “enzyme activation” appears to explain the phenomenon, i.e., phosphorylation of neither APP nor ADAM-17 dramatically increases the efficiency of ?
Positive_regulation (increases) of Phosphorylation (phosphorylation) of APP
1) Confidence 0.54 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.08
-secretase and production of a soluble secreted form of APP (sAPP?)
Positive_regulation (-) of Phosphorylation (form) of APP
2) Confidence 0.23 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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