INT180106

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.37
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rock1) cytoskeleton (Rock1) cytoskeleton organization (Rock1)
kinase activity (Rock1) cytoplasm (Rock1)
Anatomy Link Frequency
filament 1
fibroblasts 1
neurite 1
Rock1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 14 85.56 High High
cva 10 82.24 Quite High
Kinase C 30 81.28 Quite High
Spinal cord 38 54.96 Quite High
Potency 2 47.76 Quite Low
Central nervous system 60 38.72 Quite Low
Intracerebroventricular 2 33.36 Quite Low
adenocard 2 17.92 Low Low
Peripheral nervous system 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 154 99.86 Very High Very High Very High
Skin Cancer 12 98.88 Very High Very High Very High
Sarcoma 56 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 4 94.64 High High
Alzheimer's Dementia 30 93.68 High High
Glaucoma 2 88.84 High High
Carcinoma 16 86.96 High High
Ocular Hypertension 2 86.84 High High
INFLAMMATION 4 85.32 High High
Malignant Neoplastic Disease 20 84.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fasudil, the only clinically available ROCK inhibitor, can be used to predict the expected side effects of ROCK inhibitors in humans.
Regulation (effects) of ROCK
1) Confidence 0.31 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.55 Pain Relevance 0.10
Pinner and Sahai [41] showed that a fine balance between PDK1 and Rnd3 expression is required for the amoeboid movement of melanoma cells, because the two proteins have opposing roles in controlling ROCK-I activity.
Regulation (controlling) of ROCK-I associated with skin cancer
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.28 Pain Relevance 0
CA ROCK1 and DN ROCK1 molecules yielded direct and complementary evidence that ROCK1 was indeed a candidate for modulation of statin-activated ?
Regulation (modulation) of ROCK1
3) Confidence 0.19 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.09 Pain Relevance 0.11
from cultured cells, at least in part, by modulation of the isoprenoid pathway and ROCK1.



Regulation (modulation) of ROCK1
4) Confidence 0.19 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC543463 Disease Relevance 0.26 Pain Relevance 0.03
Therefore, Rho-ROCK is one of the most appropriate drug targets for counteracting the effects elicited by the different types of neurite outgrowth inhibitors.
Regulation (targets) of ROCK in neurite
5) Confidence 0.18 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.05 Pain Relevance 0.11
In mouse 3T3 fibroblasts a switch to amoeboid movement was observed upon p53 inactivation [14], while up-regulation of the Rho/ROCK signalling was found in highly metastatic rat sarcoma cells, together with the loss of MMP2 activity and an increased generation of protrusive forces, typical of the amoeboid movement [21].
Regulation (regulation) of ROCK in fibroblasts associated with sarcoma
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.67 Pain Relevance 0
It is known that the invasiveness of rounded tumor cells depends on ROCK activity, while it is independent of the activity of matrix proteases [10], [19].
Regulation (depends) of ROCK associated with cancer
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.23 Pain Relevance 0
Rounded cell morphology and cortical actin rings depend on the activity of the Rho-effector kinase ROCK, which acts by increasing myosin-II-mediated actin filament stabilization and contraction [32].
Regulation (depend) of ROCK in filament
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.24 Pain Relevance 0

General Comments

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