INT180107

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.18
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cdc42) plasma membrane (Cdc42) cytoskeleton (Cdc42)
intracellular (Cdc42) GTPase activity (Cdc42) cytoplasm (Cdc42)
Cdc42 (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 8 98.20 Very High Very High Very High
gABA 4 80.16 Quite High
Kinase C 10 79.44 Quite High
antagonist 4 77.28 Quite High
dopamine receptor 6 76.84 Quite High
Ventral tegmentum 4 71.08 Quite High
Nucleus accumbens 10 70.12 Quite High
long-term potentiation 2 60.08 Quite High
addiction 4 40.88 Quite Low
Catechol-O-methyltransferase 54 37.56 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 13 96.32 Very High Very High Very High
Neuroblastoma 11 45.28 Quite Low
Sprains And Strains 115 34.36 Quite Low
Neurodegenerative Disease 4 33.12 Quite Low
Dislocations 3 27.24 Quite Low
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 7 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downstream targets of Comt participate in cytoskeletal regulation (Cmip, Etnk1, and Ptprd), intracellular signaling (Cdc42, Araf, Hipk2, Cmip, Etnk1, Ptprd, and Rasgrp1), transport (Stau1, Adam10, Dnajc10, Mcoln1, Golga3, Arl7, Spo, Pitpnb, Ddx47, Capns1, and Kif5a), receptor/channel trafficking (Palm, Akap9, Sqstm1, Cntn2, Nsg1, and Dlgap1), synaptic maintenance and plasticity (Apba1, Tle3, Slit3, Slc12a6, Elavl4, and Syt1), transcriptional regulation (Nipbl, Myt1l, Ncor1, Jundm2, and Tef), and catecholamine metabolism (Maoa).
Regulation (regulation) of Cdc42 associated with catecholamine
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.29
Downstream targets of Comt participate in cytoskeletal regulation (Cmip, Etnk1, and Ptprd), intracellular signaling (Cdc42, Araf, Hipk2, Cmip, Etnk1, Ptprd, and Rasgrp1), transport (Stau1, Adam10, Dnajc10, Mcoln1, Golga3, Arl7, Spo, Pitpnb, Ddx47, Capns1, and Kif5a), receptor/channel trafficking (Palm, Akap9, Sqstm1, Cntn2, Nsg1, and Dlgap1), synaptic maintenance and plasticity (Apba1, Tle3, Slit3, Slc12a6, Elavl4, and Syt1), transcriptional regulation (Nipbl, Myt1l, Ncor1, Jundm2, and Tef), and catecholamine metabolism (Maoa).
Regulation (regulation) of Cdc42 associated with catecholamine
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0 Pain Relevance 0.26
AhR, CYP1A1 and cdc42 mRNA expression were quantified in AhR by real-time PCR.
Regulation (quantified) of cdc42 mRNA
3) Confidence 0.06 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
Statins also inhibit the isoprenoid pathway, thereby modulating the activities of the Rho family of small GTPases—Rho A, B, and C—as well as the activities of Rac and cdc42.
Regulation (modulating) of cdc42
4) Confidence 0.05 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC543463 Disease Relevance 0.18 Pain Relevance 0.04

General Comments

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