INT18012

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 169
Total Number 171
Disease Relevance 108.36
Pain Relevance 13.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
blood 7
kidney 6
red blood cell 5
reticulocyte 5
brain 4
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 195 100.00 Very High Very High Very High
Pain 112 99.60 Very High Very High Very High
Inflammation 281 99.24 Very High Very High Very High
vagus nerve 1 99.24 Very High Very High Very High
medulla 1015 99.14 Very High Very High Very High
dopaminergic neurodegeneration 1 99.04 Very High Very High Very High
Analgesic 7 98.88 Very High Very High Very High
cva 353 98.76 Very High Very High Very High
Nerve growth factor 17 98.76 Very High Very High Very High
pregabalin 1 97.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaemia 2838 100.00 Very High Very High Very High
Cancer 1631 99.98 Very High Very High Very High
Renal Cancer 33 99.96 Very High Very High Very High
Hyperplasia 10 99.96 Very High Very High Very High
Toxicity 102 99.92 Very High Very High Very High
Hypoxia 978 99.82 Very High Very High Very High
Acute Renal Failure 104 99.82 Very High Very High Very High
Renal Failure 138 99.78 Very High Very High Very High
Pain 92 99.60 Very High Very High Very High
Injury 447 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that the relevant axonal injury signal that stimulates EPO production from surrounding glial cells is nitric oxide.
Gene_expression (production) of EPO in glial cells associated with injury
1) Confidence 0.78 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15470751 Disease Relevance 0.60 Pain Relevance 0.07
We review data concerning site and regulation of erythropoietin (EPO) production, its effects on target tissue, routes of administration and clinical applications.
Gene_expression (production) of EPO
2) Confidence 0.78 Published 1993 Journal Neth J Med Section Abstract Doc Link 8377877 Disease Relevance 0.84 Pain Relevance 0.03
We review data concerning site and regulation of erythropoietin (EPO) production, its effects on target tissue, routes of administration and clinical applications.
Gene_expression (production) of erythropoietin
3) Confidence 0.78 Published 1993 Journal Neth J Med Section Abstract Doc Link 8377877 Disease Relevance 0.84 Pain Relevance 0.03
Erythropoietin is produced mainly by the kidneys and stimulates erythropoiesis in the bone marrow.
Gene_expression (produced) of Erythropoietin in bone marrow
4) Confidence 0.78 Published 1989 Journal DICP Section Abstract Doc Link 2669369 Disease Relevance 0.75 Pain Relevance 0.12
RESULTS: Erythropoietin was detectable in the cerebrospinal fluid in all eight patients sampled (median 92.5 mIU/ml, range 17.8-214.0 mIU/ml).
Gene_expression (detectable) of Erythropoietin in cerebrospinal fluid
5) Confidence 0.78 Published 2007 Journal Clin Oncol (R Coll Radiol) Section Body Doc Link 17305256 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: After an intravenous infusion of epoetin alpha, radiotherapy and steroids, high concentrations of erythropoietin were detectable in the cerebrospinal fluid.
Gene_expression (detectable) of epoetin alpha in cerebrospinal fluid
6) Confidence 0.78 Published 2007 Journal Clin Oncol (R Coll Radiol) Section Body Doc Link 17305256 Disease Relevance 0 Pain Relevance 0
Inappropriate erythropoietin production is regarded as one of the main causative factors responsible for the occurrence of anaemia.
Gene_expression (production) of erythropoietin associated with anaemia
7) Confidence 0.78 Published 2001 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 11860225 Disease Relevance 1.09 Pain Relevance 0.11
Formulation A (Heberitro, Heber Biotec, Havana) was in vials containing 2000 IU of human recombinant (rHu) EPO (produced in Chinese hamster ovarian (CHO) cells at CIGB, Havana), 2.5 mg serum human albumin, 0.2 mg polysorbate 20, 2.9 mg NaCl, 4.6 mg NaH2PO4.2H2O, 9.9 mg Na2HPO4, and water for injection to complete 1 mL.
Gene_expression (produced) of EPO
8) Confidence 0.78 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1164417 Disease Relevance 0.88 Pain Relevance 0
A higher fat mass may stimulate erythropoiesis through increased endogenous erythropoietin synthesis and/or sensitivity via the adipocyte hormone leptin [15,16].
Gene_expression (synthesis) of erythropoietin in adipocyte
9) Confidence 0.78 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2621153 Disease Relevance 1.07 Pain Relevance 0
After the synthesis of epoetins alpha and -beta, a third molecule of recombinant human erythropoietin (rHuEPO) was synthesized and was named epoetin-omega.
Gene_expression (synthesized) of rHuEPO
10) Confidence 0.77 Published 2002 Journal Clin. Nephrol. Section Abstract Doc Link 11924756 Disease Relevance 0.22 Pain Relevance 0.04
After the synthesis of epoetins alpha and -beta, a third molecule of recombinant human erythropoietin (rHuEPO) was synthesized and was named epoetin-omega.
Gene_expression (synthesized) of erythropoietin
11) Confidence 0.77 Published 2002 Journal Clin. Nephrol. Section Abstract Doc Link 11924756 Disease Relevance 0.22 Pain Relevance 0.04
After the synthesis of epoetins alpha and -beta, a third molecule of recombinant human erythropoietin (rHuEPO) was synthesized and was named epoetin-omega.
Gene_expression (synthesis) of epoetin
12) Confidence 0.75 Published 2002 Journal Clin. Nephrol. Section Abstract Doc Link 11924756 Disease Relevance 0.20 Pain Relevance 0.04
The objective of the study was to evaluate and compare the safety and effectiveness of epoetin omega (produced in baby hamster kidney cells) and epoetin alfa (produced in Chinese hamster ovary cells) in sustaining the correction of anemia in maintenance hemodialysis patients.
Gene_expression (produced) of epoetin in ovary associated with anaemia
13) Confidence 0.75 Published 2002 Journal Artif Organs Section Abstract Doc Link 11879235 Disease Relevance 0.17 Pain Relevance 0
However, the recent release of the full genome sequence has sparked an enormous interest in this plant, which is also increasingly being used in biotechnology for safe production of complex biopharmaceuticals.31,32 One example is the production of the highly glycosylated peptide hormone erythropoietin (EPO).33 Production of EPO was carried out in a Physcomitrella Delta-fuc-t Delta-xyl-t strain, deficient in the enzymes responsible for the plant-specific core-bound alpha 1,3-fucose and beta 1,2-xylose.
Gene_expression (production) of erythropoietin associated with sprains and strains
14) Confidence 0.75 Published 2009 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754923 Disease Relevance 0.10 Pain Relevance 0
These patients show, low serum EPO levels, normal haemoglobin oxygen affinities, and erythroid progenitors that exhibit EPO hypersensitivity [26].
Gene_expression (levels) of EPO associated with hypersensitivity
15) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.83 Pain Relevance 0.09
Polycythemia is usually attributed to pathologic erythropoietin production by the tumor or by the adjacent normal parenchyma in response to hypoxia induced by tumor growth [1].
Gene_expression (production) of erythropoietin in parenchyma associated with hypoxia, cancer and erythrocytosis
16) Confidence 0.73 Published 2006 Journal BMC Urol Section Body Doc Link PMC1590043 Disease Relevance 1.67 Pain Relevance 0.06
The serum erythropoietin levels were within the normal range in this case and dropped by 17% one year after the operation, in parallel with stabilisation of the hematocrit to normal levels.
Gene_expression (levels) of erythropoietin
17) Confidence 0.73 Published 2006 Journal BMC Urol Section Body Doc Link PMC1590043 Disease Relevance 1.82 Pain Relevance 0
Anemia is common in chronic kidney disease (CKD) and although the cause is usually multifactorial, it is primarily related to the lack of erythropoietin (EPO) production.
Gene_expression (production) of EPO in kidney associated with chronic renal failure and anaemia
18) Confidence 0.73 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.82 Pain Relevance 0
Anemia is common in chronic kidney disease (CKD) and although the cause is usually multifactorial, it is primarily related to the lack of erythropoietin (EPO) production.
Gene_expression (production) of erythropoietin in kidney associated with chronic renal failure and anaemia
19) Confidence 0.73 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.82 Pain Relevance 0
There are few studies detailing the expression of Epo and its receptors in non-tumour-related human brain disease in adults [12-14] and using sensitive detection systems so the first aim was to define the frequency and distribution of expression in the medulla of severe malaria and non-infectious deaths.
Gene_expression (expression) of Epo in medulla associated with malaria, medulla, brain disease and cancer
20) Confidence 0.71 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.09 Pain Relevance 0.31

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